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Mucosal malignant melanoma of the oral cavity is an extremely rare condition. It has a poor prognosis. Here we report two typical cases of malignant melanoma. In the first case, 64 years old man developed an exophytic tumor in the hard palate. Head and neck and chest computerized tomography scan showed a large aggressive tumor of the hard palate. The patient also had multiple lung metastases and a cervical lymph node. The second case is a 73 years old woman presenting a burgeoning mass on the right palate. Facial CT reveals a malignant tumor lateralized in the right palate with ipsilateral metastatic lymph nodes. Histological with immunohistochemical studies assigned both cases to a malignant melanoma. Due to the rarity of oral malignant melanomas, case reports are a necessary source of information.

IntroductionNon-Hodgkin’s lymphoma of the gallbladder is a rare location of lymphoma.Case presentationWe report a case of T cell non-Hodgkin’s lymphoma (NHL) of the gallbladder in a 39-year-old man in whom cholecystectomy made the diagnosis. Abdominal ultrasound did not reveal gallbladder stones. At this time, our patient had no lymph nodes. Histopathology of gastric and pulmonary biopsy and cholecystectomy made a definite diagnosis of non-Hodgkin’s T cell lymphoma. Our patient had eight cycles of chemotherapy CHOP 21 (cyclophosphamide 750 mg/m 2 intravenously (IV) on day 1, doxorubicine 50 mg IV on day 1, vincristine 1.4 mg/m 2 IV on day 1, and prednisone 40 mg/m 2 per day from day 1 to day 5 per os) with good response. He was free of disease 12 months after completion of chemotherapy. Gallbladder location of NHL is rare and has to be suspected every time when lymph nodes are associated, and we postulate that delays in making the diagnosis may lead to underdiagnosis of lymphoma of the gallbladder.ConclusionReview of the literature shows the existence of non-Hodgkin’s lymphoma of the gallbladder, its rarity, and its general dismal prognosis. Our case illustrated that the prognosis could be improved by correct chemotherapy. IntroductionLe lymphome non hodgkinien de la vesicule biliaire est une localisation extraganglionnaire rare de lymphome.Cas cliniqueNous rapportons un cas de lymphome T non hodgkinien (LNH) de la vesicule biliaire chez un homme de 39 ans, chez qui, une cholecystectomie a fait le diagnostic. Une echographie abdominale n’a pas revele de calculs vesiculaires. A cette epoque, notre patient n’avait pas de ganglions lymphatiques palpables. L’histopathologie de la biopsie gastrique et pulmonaire ainsi que la cholecystectomie ont pose le diagnostic de LNH a cellules T. Notre patient a recu huit cycles de chimiotherapie de type CHOP 21 avec une bonne reponse. Il est actuellement en remission a 12 mois apres la fin de la chimiotherapie. La localisation au niveau de la vesicule biliaire d’un LNH est rare et doit etre suspectee a chaque fois que nous avons des ganglions lymphatiques associes et nous postulons que les retards apportes dans le diagnostic peuvent conduire a une meconnaissance de ce diagnostic de lymphome de la vesicule biliaire.ConclusionUne revue de la litterature montre la rarete d’un lymphome non hodgkinien de la vesicule biliaire, et notre cas montre bien que le pronostic pourrait etre modifie par la chimiotherapie.