1. Flavonoids Distinctly Stabilize Lymph Endothelial- or Blood Endothelial Disintegration Induced by Colon Cancer Spheroids SW620
- Author
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Christa Stadlbauer, Nicole Huttary, Karin Taxauer, Liselotte Krenn, Claudia Smöch, Julia Berenda, Georg Krupitza, and Eva Mittermair
- Subjects
colon cancer emboli ,Pharmaceutical Science ,Pharmacology ,Flavones ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Wogonin ,lcsh:Organic chemistry ,Spheroids, Cellular ,endothelial cell micro-environment ,Drug Discovery ,Humans ,heterocyclic compounds ,Chrysin ,Physical and Theoretical Chemistry ,030304 developmental biology ,Flavonoids ,chemistry.chemical_classification ,0303 health sciences ,Neovascularization, Pathologic ,Acacetin ,structure-activity relationship ,fungi ,Organic Chemistry ,food and beverages ,Endothelial Cells ,Antineoplastic Agents, Phytogenic ,Coculture Techniques ,3D co-cultivation ,anti-metastatic ,chemistry ,Chemistry (miscellaneous) ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Apigenin ,Molecular Medicine ,Hispidulin ,Endothelium, Vascular ,Luteolin ,Nepetin - Abstract
The health effects of plant phenolics in vegetables and other food and the increasing evidence of the preventive potential of flavonoids in &ldquo, Western Diseases&rdquo, such as cancer, neurodegenerative diseases and others, have gained enormous interest. This prompted us to investigate the effects of 20 different flavonoids of the groups of flavones, flavonols and flavanones in 3D in vitro systems to determine their ability to inhibit the formation of circular chemorepellent induced defects (CCIDs) in monolayers of lymph- or blood-endothelial cells (LECs, BECs, respectively) by 12(S)-HETE, which is secreted by SW620 colon cancer spheroids. Several compounds reduced the spheroid-induced defects of the endothelial barriers. In the SW620/LEC model, apigenin and luteolin were most active and acacetin, nepetin, wogonin, pinocembrin, chrysin and hispidulin showed weak effects. In the SW620/BEC model acacetin, apigenin, luteolin, wogonin, hispidulin and chrysin exhibited weak activity.
- Published
- 2020
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