1. Prognosis of patients with systemic sclerosis-related interstitial lung disease on the lung transplant waiting list: a retrospective study.
- Author
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Nakayama, Yoichi, Nakashima, Ran, Handa, Tomohiro, Ohsumi, Akihiro, Yamada, Yoshito, Nakajima, Daisuke, Yutaka, Yojiro, Tanaka, Satona, Hamada, Satoshi, Ikezoe, Kohei, Tanizawa, Kiminobu, Shirakashi, Mirei, Hiwa, Ryosuke, Tsuji, Hideaki, Kitagori, Koji, Akizuki, Shuji, Yoshifuji, Hajime, Date, Hiroshi, and Morinobu, Akio
- Subjects
INTERSTITIAL lung diseases ,SURVIVAL analysis (Biometry) ,LUNG transplantation ,LUNGS ,VITAL capacity (Respiration) ,LUNG diseases ,PROGNOSIS - Abstract
Advanced systemic sclerosis-associated interstitial lung disease (SSc-ILD) can be treated with lung transplantation. There is limited data on lung transplantation outcomes in patients with SSc-ILD, in non-Western populations.We assessed survival data of patients with SSc-ILD, on the lung transplant (LT) waiting list, and evaluated post-transplant outcomes in patients from an Asian LT center. In this single-center retrospective study, 29 patients with SSc-ILD, registered for deceased LT at Kyoto University Hospital, between 2010 and 2022, were identified. We investigated post-transplant outcomes in recipients who underwent LT for SSc-ILD, between February 2002 and April 2022. Ten patients received deceased-donor LT (34%), two received living-donor LT (7%), seven died waiting for LT (24%), and ten survived on the waiting list (34%). Median duration from registration to deceased-donor LT was 28.9 months and that from registration to living-donor LT or death was 6.5 months. Analysis of 15 recipients showed improved forced vital capacity with a median of 55.1% at baseline, 65.8% at 6 months, and 80.3% at 12 months post-transplant. The 5-year survival rate for post-transplant patients with SSc-ILD was 86.2%. The higher post-transplant survival rate at our institute than previously reported suggests that lung transplantation is acceptable in Asian patients with SSc-ILD. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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