1. The association between gut butyrate-producing bacteria and non-small-cell lung cancer.
- Author
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Gui Q, Li H, Wang A, Zhao X, Tan Z, Chen L, Xu K, and Xiao C
- Subjects
- Aged, Bacteria metabolism, Case-Control Studies, Feces microbiology, Female, Humans, Male, Middle Aged, Butyrates metabolism, Carcinoma, Non-Small-Cell Lung metabolism, Carcinoma, Non-Small-Cell Lung microbiology, Dysbiosis metabolism, Dysbiosis microbiology, Gastrointestinal Microbiome physiology, Lung Neoplasms metabolism, Lung Neoplasms microbiology
- Abstract
Background: Recently, it has been found that the gut microbiota may affect the development of lung cancer through the "gut-lung axis." To investigate this relationship, we performed this study to determine whether the gut microbiota in non-small-cell lung cancer (NSCLC) patients is different from that in healthy adults., Methods: Quantitative PCR (qPCR) was used to detect the expression levels of eight gut butyrate-producing bacteria in healthy adults and NSCLC patients. We enrolled 30 patients with NSCLC and 30 subjects from 100 healthy adults after matching for age and sex., Results: Compared to healthy adults, most of the gut butyrate-producing bacteria in NSCLC patients were significantly decreased; these included Faecalibacterium prausnitzii, Clostridium leptum, Clostridial cluster I, Ruminococcus spp., Clostridial Cluster XIVa, and Roseburia spp. Among the gut butyrate-producing bacteria, we analyzed Clostridial cluster IV and Eubacterium rectale were not decreased in NSCLC patients., Conclusions: We conclude that NSCLC patients had gut butyrate-producing bacteria dysbiosis. Further studies should be performed to investigate the underlying mechanisms of how these specific bacteria affect lung cancer progression and prognosis., (© 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, LLC.)
- Published
- 2020
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