1. The CONUT score is associated with the pathologic grade in non-small cell lung cancer.
- Author
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Onodera K, Notsuda H, Watanabe T, Watanabe Y, Suzuki T, Hirama T, Oishi H, Niikawa H, Noda M, and Okada Y
- Subjects
- Humans, Male, Female, Aged, Prognosis, Middle Aged, Retrospective Studies, Survival Rate, Neoplasm Invasiveness, Nutritional Status, Preoperative Period, Risk, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms pathology, Lung Neoplasms mortality, Lung Neoplasms surgery, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Neoplasm Grading
- Abstract
Purpose: Nutritional scores have been reported to be useful prognostic factors for various cancers. This study evaluated the usefulness of the preoperative controlling nutritional status (CONUT) score as a predictor of recurrence of non-small cell lung cancer (NSCLC)., Methods: The present study included 422 patients with stage I-IIIA NSCLC who underwent complete resection at Tohoku University Hospital between January 2010 and December 2016. The patients were divided into the low-CONUT and high-CONUT groups based on their CONUT scores. Overall survival (OS), recurrence-free survival (RFS), and cumulative recurrence rates in the low- and high-CONUT groups were evaluated retrospectively., Results: One hundred forty-seven patients (34.8%) were assigned to the high-CONUT group. The high-CONUT group had a significantly worse performance status, pleural invasion, vascular invasion, and lung metastasis. In the whole cohort, the low-CONUT group showed better overall survival, recurrence-free survival, and a low cumulative recurrence rate in comparison to the high-CONUT group. There was no significant difference in prognosis or recurrence between the low- and high-CONUT groups after propensity score matching., Conclusion: Patients with a high CONUT score may be at high risk of recurrence because of the high frequency of pleural invasion, vascular invasion, and lung metastasis., Competing Interests: Declarations. Conflict of interest: The authors declare no conflicts of interest in association with the present study., (© 2024. The Author(s).)
- Published
- 2024
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