Search

Your search keyword '"Xu, Chuan-Yi"' showing total 2 results
Start Over Author "Xu, Chuan-Yi" Topic lung
2 results on '"Xu, Chuan-Yi"'

1. The harmful effect of prolonged high-dose methylprednisolone in acute lung injury.

Author

Teng D, Pang QF, Yan WJ, Zhao Xin W, and Xu CY

Subjects
Acute Lung Injury immunology, Animals, Bronchoalveolar Lavage Fluid chemistry, Bronchoalveolar Lavage Fluid immunology, Drug Dosage Calculations, Humans, Infusions, Intravenous, Lipopolysaccharides immunology, Lung immunology, Macrophages, Alveolar immunology, Male, Methylprednisolone administration & dosage, Rats, Rats, Sprague-Dawley, Time Factors, Acute Lung Injury drug therapy, Collagen Type III metabolism, Lung drug effects, Macrophages, Alveolar drug effects, Methylprednisolone adverse effects
Abstract

Although many literatures have shown that prolonged high-dose administration of corticosteroids is hazardous and not indicated to therapy acute lung injury (ALI), there is little information on the harmful effect of prolonged high-dose corticosteroids in acute lung injury. In this study, we aimed to investigate the effect of prolonged high-dose methylprednisolone (MPL) on ALI and improve knowledge regarding the appropriate use of corticosteroids in ALI. The different doses of MPL (3, 30, 180mg·kg(-1)) were given via tail vein injection 1h after the first time LPS administration and were daily administrated for 14days. Lung tissues and lavage samples were isolated for biochemical determinations and histological measurements at 12h, 7days and 14days after LPS administration. Single administration of 180mg·kg(-1) MPL decreased the lung injury score, wet-to-dry ratio, the total cell numbers and level of procollagen type III in BALF at 12h after LPS challenge. However, prolonged therapy with 180mg·kg (-1) MPL for 7days and 14days decreased the number of AMs in BALF and increased the above-mentioned indexes. These results suggested that the prolonged high-dose MPL has harmful effects to treat LPS-induced ALI in rats., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2013
Full Text
View/download PDF

2. Caveola is a key vehicle for paraquat uptake into lung

Author

Pang Qingfeng, Xu chuan-yi, Zhao jing, and Yan wen-jing

Subjects
Paraquat, Lung, Polyamine transport, Caveola, Clone (cell biology), General Medicine, respiratory system, Biology, Pharmacology, chemistry.chemical_compound, medicine.anatomical_structure, Biochemistry, chemistry, Caveolae, medicine, High incidence, Lung tissue, Polyamine
Abstract

Paraquat dichloride (PQ) is an effective and widely used herbicide for eliminating weeds. However, once being accidentally or voluntarily ingested, PQ-poisoned patients have the very high incidence of adult respiratory distress syndrome because lung can actively absorb PQ. Since the 1970s, evidence suggested that polyamine competitively inhibited uptake of PQ into lung tissue; therefore, polyamine transport system has been regarded as an important vehicle for PQ uptake into lung. However, so far, we cannot clone or detect the polyamine transport system in mammalian animal. Recent evidence from diverse sources has suggested that caveola may be an important vehicle for polyamine absorption into lung. Herein we hypothesise that caveola is a key vehicle for PQ uptake in lung and hence blocking the expression of caveola may serve as new targets for treatment of PQ poisoning.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results