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A reactant volume self-controlled micro-device was presented and applied to the flow injection chemiluminescence (CL) for determination of cyanide in whole blood. A mini distiller was fabricated for cyanide extraction from the blood samples with the extraction efficiencies of cyanide ≥98%. A fluidic control platform with air driving was fabricated. The described system showed the features of easy fabrication, undiluted sample injection, safe analysis operation, and suitability for automatic cyanide analysis. The calibration curve showed linearity in the cyanide concentration range of 5.0×10-7 to 5.0×10-5 mol l-1 with the detection limits (3σ) of 2.3×10-7 mol l-1. CL peak-height precision was 1.9% R.S.D. (n=11) at the 1.0×10-6 mol l-1 cyanide level. The new devices were applied to the analysis of cyanide in rabbit whole blood samples and the results agreed well with those obtained from official method. [Copyright &y& Elsevier]

A mircrofluidic chip, based on using an air stream for fluidic controlling and coupled with chemiluminescence (CL) detection, was presented. The reported design promised a simple, low cost chip fabrication, and an easy operation. With each assay time less than 3 min, the described microfluidic chip was applied in determination of iron(II) content in nature water and total iron content in whole blood. Experiment results showed the potential for a multitude of applications of the presented chip. The calibration graph of chemiluminescent intensity (ICL) vs. iron(II) concentration was linear in the range 1.0 × 10-6-5.0 × 10-5 mol L-1, and the detection limit (DL) was 3.0 × 10-7 mol L-1 (3σ). [ABSTRACT FROM AUTHOR]