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2 results on '"Arena, Vittoria"'

1. Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region.

Author

Lugli, Licia, Pugliese, Marisa, Plessi, Carlotta, Berardi, Alberto, Guidotti, Isotta, Ancora, Gina, Grandi, Sara, Gargano, Giancarlo, Braibanti, Silvia, Sandri, Fabrizio, Soffritti, Silvia, Ballardini, Elisa, Arena, Vittoria, Stella, Marcello, Perrone, Serafina, Moretti, Sabrina, Rizzo, Vittoria, Ferrari, Fabrizio, Picciolini, Odoardo, and Bellù, Roberto

Subjects
LOW birth weight, CEREBRAL palsy, DEVELOPMENTAL disabilities, FUNCTIONAL assessment, LONGITUDINAL method, NEONATAL intensive care, RISK assessment, NEONATAL intensive care units, DESCRIPTIVE statistics, DISEASE risk factors
Abstract

Introduction: The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. Aims: Neuroprem is an area-based prospective cohort study on the neuro-developmental outcome of very low birth weight (VLBW) infants that aims to define severe functional disability at 2 years of age. Methods: Surviving VLBW infants from an Italian network of 7 neonatal intensive care units (NICUs) were assessed for 24 months through the Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and neuro-functional evaluation according to the International Classification of Disability and Health (ICF-CY). The primary outcome measure was severe functional disability at 2 years of age, defined as cerebral palsy, a BSDI III cognitive composite score < 2 standard deviation (SD) or a GMDS-R global quotients score < 2 SD, bilateral blindness or deafness. Results: Among 211 surviving VLBW infants, 153 completed follow-up at 24 months (72.5%). Thirteen patients (8.5%) developed a severe functional disability, of whom 7 presented with cerebral palsy (overall rate of 4.5%). Patients with cerebral palsy were all classified with ICF-CY scores of 3 or 4. BSDI III composite scores and GMDS-R subscales were significantly correlated with ICF-CY scores (p < 0.01). Conclusion: Neuroprem represents an Italian network of NICUs aiming to work together to ensure preterm neuro-developmental assessment. This study updates information on VLBW outcomes in an Italian region, showing a rate of cerebral palsy and major developmental disabilities in line with or even lower than those of similar international studies. Therefore, Neuroprem provides encouraging data on VLBW neurological outcomes and supports the implementation of a preterm follow-up programme from a national network perspective. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

Author

Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti, Vittoria Rizzo, Fabrizio Ferrari, Neuroprem Working Group, Odoardo Picciolini, Roberto Bellù, Daniela Turoli, Luigi Tommaso Corvaglia, Gianpaolo Garani, Vittoria Paoletti, Giacomo Biasucci, Augusto Biasini, Belinda Benenati, Paolo Stagi, Cristina Magnani, Sara Dallaglio, Elisa DellaCasa Muttini, Maria Federica Roversi, Luca Bedetti, Laura Lucaccioni, Natascia Bertoncelli, Alessandra Boncompagni, Lugli, Licia, Pugliese, Marisa, Plessi, Carlotta, Berardi, Alberto, Guidotti, Isotta, Ancora, Gina, Grandi, Sara, Gargano, Giancarlo, Braibanti, Silvia, Sandri, Fabrizio, Soffritti, Silvia, Ballardini, Elisa, Arena, Vittoria, Stella, Marcello, Perrone, Serafina, Moretti, Sabrina, Rizzo, Vittoria, Ferrari, Fabrizio, Picciolini, Odoardo, Bellù, Roberto, Turoli, Daniela, Corvaglia, Luigi Tommaso, Garani, Gianpaolo, Paoletti, Vittoria, Biasucci, Giacomo, Biasini, Augusto, Benenati, Belinda, Stagi, Paolo, Magnani, Cristina, Dallaglio, Sara, DellaCasa Muttini, Elisa, Roversi, Maria Federica, Bedetti, Luca, Lucaccioni, Laura, Bertoncelli, Natascia, and Boncompagni, Alessandra

Subjects
Male, Pediatrics, medicine.medical_specialty, genetic structures, Italy, Neuro-developmental outcome, Very low birth weight preterm, Socio-culturale, Gestational Age, Bayley Scales of Infant Development, Cerebral palsy, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Child Development, Intensive care, medicine, Humans, Infant, Very Low Birth Weight, 030212 general & internal medicine, Toddler, Prospective cohort study, Child, business.industry, Research, Cerebral Palsy, lcsh:RJ1-570, Infant, Newborn, Infant, lcsh:Pediatrics, medicine.disease, Child development, Low birth weight, Neurodevelopmental Disorders, Child, Preschool, Female, medicine.symptom, Cohort Studie, business, 030217 neurology & neurosurgery, Infant, Premature, Cohort study, Human
Abstract

Introduction The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. Aims Neuroprem is an area-based prospective cohort study on the neuro-developmental outcome of very low birth weight (VLBW) infants that aims to define severe functional disability at 2 years of age. Methods Surviving VLBW infants from an Italian network of 7 neonatal intensive care units (NICUs) were assessed for 24 months through the Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and neuro-functional evaluation according to the International Classification of Disability and Health (ICF-CY). The primary outcome measure was severe functional disability at 2 years of age, defined as cerebral palsy, a BSDI III cognitive composite score Results Among 211 surviving VLBW infants, 153 completed follow-up at 24 months (72.5%). Thirteen patients (8.5%) developed a severe functional disability, of whom 7 presented with cerebral palsy (overall rate of 4.5%). Patients with cerebral palsy were all classified with ICF-CY scores of 3 or 4. BSDI III composite scores and GMDS-R subscales were significantly correlated with ICF-CY scores (p Conclusion Neuroprem represents an Italian network of NICUs aiming to work together to ensure preterm neuro-developmental assessment. This study updates information on VLBW outcomes in an Italian region, showing a rate of cerebral palsy and major developmental disabilities in line with or even lower than those of similar international studies. Therefore, Neuroprem provides encouraging data on VLBW neurological outcomes and supports the implementation of a preterm follow-up programme from a national network perspective.

Published
2020

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