1. COVID-19 Infection despite Previous Vaccination in Cancer Patients and Healthcare Workers: Results from a French Prospective Multicenter Cohort (PAPESCO-19).
- Author
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Seegers, Valérie, Rousseau, Guillaume, Zhou, Ke, Blanc-Lapierre, Audrey, Bigot, Frédéric, Mahammedi, Hakim, Lambert, Aurélien, Moreau-Bachelard, Camille, Campone, Mario, Conroy, Thierry, Penault-Llorca, Frédérique, Bellanger, Martine M., and Raoul, Jean-Luc
- Subjects
RESEARCH ,COVID-19 ,IMMUNIZATION ,COVID-19 vaccines ,AGE distribution ,CANCER chemotherapy ,CANCER patients ,SEX distribution ,GASTROINTESTINAL tumors ,RISK assessment ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,RESEARCH funding ,RADIOTHERAPY ,COVID-19 pandemic ,LONGITUDINAL method ,FEMALE reproductive organ tumors ,IMMUNOTHERAPY ,DISEASE complications - Abstract
Simple Summary: In two cohorts of vaccinated cancer patients and healthcare workers, 5% had COVID-19 infection after vaccination. These infections occurred more frequently in younger cancer patients with gastrointestinal cancer, gynecological or breast cancer, or a localized cancer and in patients receiving chemotherapy or targeted therapy when vaccinated. In both cohorts, these breakthrough infections occurred early after initiation of vaccination (Alpha SARS-CoV-2 variant) or several months after the end of vaccination (Omicron SARS-CoV-2 variant). In both cohorts these COVID-19 cases in vaccinated individuals were not severe, with only four cancer patients requiring oxygen therapy. In a multicenter prospective cohort of cancer patients (CP; n = 840) and healthcare workers (HCWs; n = 935) vaccinated against COVID-19, we noticed the following: i/after vaccination, 4.4% of HCWs and 5.8% of CP were infected; ii/no characteristic was associated with post-vaccine COVID-19 infections among HCWs; iii/CP who developed infections were younger, more frequently women (NS), more frequently had gastrointestinal, gynecological, or breast cancer and a localized cancer stage; iv/CP vaccinated while receiving chemotherapy or targeted therapy had (NS) more breakthrough infections after vaccination than those vaccinated after these treatments; the opposite was noted with radiotherapy, immunotherapy, or hormonotherapy; v/most COVID-19 infections occurred either during the Alpha wave (11/41 HCW, 20/49 CP), early after the first vaccination campaign started, or during the Omicron wave (21/41 HCW, 20/49 CP), more than 3 months after the second dose; vi/risk of infection was not associated with values of antibody titers; vii/the outcome of these COVID-19 infections after vaccination was not severe in all cases. To conclude, around 5% of our CPs or HCWs developed a COVID-19 infection despite previous vaccination. The outcome of these infections was not severe. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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