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Objective: This study aimed to investigate interactions among physical fitness, sleep quality, sedentary behavior, and depression among female college freshmen. Participants: A cohort of 1,514 Chinese female college freshmen (Mage = 18.8 ±.63) were recruited from four universities. Methods: Participants completed a survey assessing depression, sleep quality (sleep duration and sleep onset latency), and sedentary behavior, and performed physical fitness measurements. Results: Physical fitness indexes were associated with sleep quality and sedentary behavior (ps <.05) but not with depression. Depression was positively associated with sedentary behavior and sleep onset latency, but negatively associated with sleep duration (ps <.01). The model tests revealed that sleep quality (β = −.57, p <.01) and sedentary behavior (β =.14, p <.01) served as mediators between physical fitness and depression, respectively. Conclusions: Increasing sleep quality and minimizing sedentary behavior may build resilience to depression among Chinese female college freshmen. [ABSTRACT FROM AUTHOR]

This study examined the relationship between physical literacy (i.e., motor competence, physical activity, and health-related fitness) and academic performance (i.e., executive function, class attendance, and standardized test scores) among adolescents. Second, we investigated whether these relationships differ between boys and girls using a structural invariable test. Using a prospective research design, we recruited 330 adolescents (154 boys and 176 girls; M age = 12.52 years, SD = 0.86) in Texas and conducted correlational analyses, finding that physical literacy variables were significantly related to executive function (while the r s range was from −.16 to −.30, the high scores on the instrument we used, the Behavior Rating Inventory of Executive Function, indicate higher risks for executive dysfunction; p <.01) and positively associated with school attendance (r s range from.19 to.34; p <.05). Structural equation models supported the significant direct and indirect effects of motor competence on executive function and school attendance for boys and girls through physical fitness (all three components) and school-based moderate-to-vigorous physical activity, respectively. The structural invarince test indicated noninvariant models (based on path coefficients) between girls and boys (p <.01). Embracing psychomotor associations with physical literacy may be a promising way to elicit behavioral change in physical fitness and create a behavioral channel to academic success for adolescents. [ABSTRACT FROM AUTHOR]

Background: A prospective study was performed to investigate the prevalence of colonization among ICU patients and to examine whether asymptomatic carriers were the source of subsequent C. difficile infection (CDI) and acquisition of toxigenic C. difficile.Methods: Rectal swabs were collected from adult patients on admission to and at discharge from a 50-bed medical ICU of a major referral hospital in western China, from August to November 2014. Stools were collected from patients who developed ICU-onset diarrhea. Both swabs and stools were screened for tcdB (toxin B gene) by PCR. Samples positive to tcdB were cultured for C. difficile and isolates recovered were screened for tcdB and the binary toxin genes by PCR. Strain typing was performed using multilocus sequence typing and isolates belonging to the same sequence type (ST) were further typed using multiple-locus variable number tandem repeat analysis (MLVA).Results: During the 4-month period, rectal swabs were collected from 360 (90.9 %) out of 396 patients who were admitted to the ICU. Among the 360 patients, 314 had stayed in the ICU more than 3 days, of which 213 (73.6 %) had a rectal swab collected within the 3 days prior to discharge from ICU. The prevalence of toxigenic C. difficile colonization was 1.7 % (6 cases) and 4.3 % (10 cases) on admission and discharge, respectively. Only four (1.1 %) out of 360 patients had CDI, corresponding to 10.7 cases per 10,000 ICU days. None of the four cases had toxigenic C. difficile either on admission or at discharge. Toxigenic C. difficile isolates were recovered from all swabs and stool samples positive for tcdB by PCR and belonged to 7 STs (ST2, 3, 6, 37, 54, 103 and 129). None of the isolates belonging to the same ST had identical MLVA patterns. Binary toxin genes were detected in one ST103 isolate that caused colonization.Conclusion: The prevalence of colonization with toxigenic C. difficile among patients on admission to ICU was low in our setting. ICU-acquired toxigenic C. difficile were not linked to those detected on admission. Active screening for toxigenic C. difficile may not be a resource-efficient measure in settings with a low prevalence of colonization. [ABSTRACT FROM AUTHOR]

An innovative structure for a heavy haul coupler with an arc surface contact and restoring bumpstop is proposed. This coupler has a small lateral force at a small yaw angle and a limitable yaw angle to ensure an allowable coupler lateral force under intense compressive force. The main structural characteristic of the combined contact coupler is a lateral movable follower with an appropriate friction coefficient of 0.06–0.08 and a slide block with a single freedom of longitudinal movement. In order to verify and simulate the performances, a multi-body dynamics model with four heavy haul locomotives and three detailed couplers was established to simulate the process of emergency braking. In addition, the coupler yaw instability and wheel set lateral forces were tested in order to investigate the effect of relevant parameters on the coupler performances. The combined contact coupler is suitable for heavy haul train for a good dynamic performance. [ABSTRACT FROM PUBLISHER]

we present a stable and high efficiency single-longitudinal-mode (SLM) fiber ring laser by using polarization-maintaining fiber Bragg grating Fabry-Perot (PM FBG F-P) etalon combining PM fiber saturable absorber. The PM FBG F-P etalon, which is directly fabricated in hydrogen-loaded PM fiber, is used as reflector and mode-selecting component to reduce the longitudinal-mode density greatly. Meanwhile, a segment un-pumped PM Er-doped fiber (EDF) serves as saturable absorber to suppress mode hopping and ensure the stable SLM operation. Stable SLM laser output at 1550.4 nm with linewidth of 2.0 kHz is observed. Laser output power is 43.7 mW for a pump power of 148 mW, optical-optical efficiency is 29.5% and signal-to-noise ratio (SNR) is larger than 55 dB. [ABSTRACT FROM AUTHOR]

Background: Weight loss is an important side effect of long-term anticancer treatment for nasopharyngeal carcinoma patients. The decline in body function will cause many adverse effects, such as local recurrence and distant metastasis, and reduce the patient's quality of life. Therefore, this study developed a predictive model for the probability of critical weight loss to provide timely appropriate nutritional interventions and prevent serious side effects. Methods: A 20-week prospective follow-up study of 137 nasopharyngeal carcinoma patients in West China Hospital of Sichuan University undergoing radiotherapy and chemotherapy from February 2018 to March 2020 was conducted to collect relevant clinical data. The clinical usefulness and calibration of the prediction model were assessed using the C-index, calibration plot, receiver operating curve, and decision curve analysis. Internal validation was assessed using bootstrapping validation. Results: The nomogram consisted of sex, smoking status, physical status, chemotherapy regimen, and body mass index. Good calibration was observed for the cohort, with an area under the curve of 0.924. Five independent prognostic factors were included in the nomogram, which showed a high C-index value of 0.815 in the interval validation. Decision curve analysis showed that the nomogram was clinically useful when the intervention was decided at the critical weight loss possibility threshold in the 0% to 97% range. Conclusions: We constructed and validated a nomogram for predicting the incidence of critical weight loss in nasopharyngeal cancer patients undergoing chemotherapy and radiotherapy. [ABSTRACT FROM AUTHOR]

The negative synergistic effect of cancer and a peripherally inserted central catheter could significantly increase the incidence of thrombosis. Rather than identifying risk factors for peripherally inserted central catheter–related thrombosis, exploring the effect of these risk factors might be a promising method to improve the outcomes of thrombosis. To analyze the effect of systemic and local risk factors on triggering peripherally inserted central catheter–related thrombosis in the first two weeks post–insertion in cancer patients. A prospective cohort study. The study was conducted at a 4500-bed university-affiliated medical center in China. One hundred seventy-three cancer patients with peripherally inserted central catheters were included. Peripherally inserted central catheter–related thrombosis was assessed using ultrasound at a series of timepoints, once every two days post–insertion. Data on age, body mass index, blood hypercoagulation, insertion attempts, catheter-to-vein ratio, and blood flow velocity were collected as risk factors. Descriptive statistics and structural equation modeling were used to describe the study samples and analyze the effects of systemic and local risk factors. Among the 173 cancer patients included, 126 (72.8%) patients were diagnosed with peripherally inserted central catheter–related thrombosis. Most thromboses (n = 118, 93.7%) were detected within five days, and 100% were detected within nine days post–insertion. Structural equation modeling analysis showed that local risk factors [catheter-to-vein ratio (standardized path coefficient = 0.32, p < 0.05) and blood flow velocity (standardized path coefficient = −0.35, p < 0.05)] had a greater effect than systemic factors [age (standardized path coefficient = 0.13, p < 0.05) and blood hypercoagulation (standardized path coefficient = 0.17, p < 0.05)] on triggering peripherally inserted central catheter–related thrombosis. Peripherally inserted central catheter–related thrombosis is quite common and can occur very early post–insertion in cancer patients. Among the common risk factors, local risk factors reflecting peripherally inserted central catheter technology itself had a greater effect than systemic risk factors reflecting predisposition to thrombosis. Clinical Registration: Clinical Trials ChiCTR1900024890. [ABSTRACT FROM AUTHOR]