1. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.
- Author
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Korkushko OV, Khavinson VKh, Shatilo VB, and Antonyuk-Shcheglova IA
- Subjects
- Aged, Coronary Disease epidemiology, Coronary Disease mortality, Exercise Tolerance drug effects, Follow-Up Studies, Humans, Incidence, Middle Aged, Peptides adverse effects, Peptides chemistry, Respiratory Tract Diseases epidemiology, Respiratory Tract Diseases mortality, Time Factors, Treatment Outcome, Coronary Disease complications, Longevity drug effects, Peptides pharmacology, Pineal Gland chemistry
- Abstract
A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system. Long-term treatment with epithalamine decreased the functional age and degree of cardiovascular aging; exercise tolerance increased. After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy. Cardiovascular mortality was 2-fold lower in patients treated by epithalamine; the incidence of cardiovascular failure and respiratory diseases was 2-fold lower in this group. Long-term treatment with epithalamine was associated with a geroprotective effect on the long-term life prognosis in elderly subjects with accelerated aging.
- Published
- 2006
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