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Objective: To investigate the relationship between preoperative prognostic nutrition index (PNI) and prognosis of patients with lung squamous cell carcinoma and its predictive effect on postoperative recurrence and death. Methods: A total of 78 patients with lung squamous cell carcinoma who received treatment in our hospital from January 2017 to January 2019 were included. All patients had complete clinical data and pathological information, and they were reviewed and followed up in the outpatient department for 3 years. In addition to the lost cases, 76 patients were included, during the period, 43 patients recurred and 37 patients died. The 76 patients were divided into recurrence group (n=43) and non-recurrence group (n=33), death group (n=37) and survival group (n=39) according to the recurrence and death conditions. The independent risk factors affecting the recurrence and death of patients with lung squamous cell carcinoma were analyzed by univariate and multivariate Logistic regression. The receiver operating characteristic (ROC) curve was used to analyze the predictive efficacy and optimal cutoff value of PNI in the postoperative recurrence and death of patients with lung squamous cell carcinoma. Results: Univariate analysis showed that TNM stage, smoking years, diabetes, family history, PNI were the related factors affecting the postoperative recurrence of patients with lung squamous cell carcinoma (P<0.05). Gender, age, TNM stage, BMI, smoking history, smoking years and PNI were the related factors affecting the postoperative death of patients with lung squamous cell carcinoma (P<0.05). Multivariate Logistic regression model analysis showed that TNM stage III, long smoking years and family history were independent risk factors for postoperative recurrence of patients with lung squamous cell carcinoma, and PNI was protective factor (P<0.05). In addition, male, older age, TNM stage III, and longer smoking years were independent risk factors for postoperative death of patients with lung squamous cell carcinoma, and PNI was the protective factor (P<0.05). ROC results showed that the area under curve of PNI in predicting postoperative recurrence of patients with lung squamous cell carcinoma was 0.746 the sensitivity was 83.72%, the specificity was 63.64%, and the best cutoff value was less than or equal to 49.90. The area under curve of PNI in predicting postoperative survival of patients with lung squamous cell carcinoma was 0.761, the sensitivity was 86.49%, the specificity was 66.67%, and the best cutoff value was less than or equal to 50.41. Conclusion: PNI has high predictive efficacy for postoperative recurrence and survival of patients with lung squamous cell carcinoma, increasing PNI level has a positive effect on improving the prognosis of patients with lung squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)