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Objective: To explore the correlation between the marital status and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). Study design: MPSM was adopted to minimize the maximum standardized average difference of the covariates among the four groups with different marital status. Setting: Multinomial propensity scores matching (MPSM) based on data from the surveillance, epidemiology, and end results (SEER) database. Methods: The Kaplan–Meier method and log-rank test were used to compare the survival outcomes of these groups with different marital status. Results: Totally, 16,981 LSCC patients (median [IQR] age 62 [55–69] years; 829 [76.41%] males) from 2004 to 2016 were included in this study. Among them, 9112 (53.66%) were married, 2708 (15.95%) divorced or separated, 1709 (10.06%) widowed, and 3452 (20.33%) single. After MPSM, the weights make the characteristics of four groups with different marital status sufficient balance. The Kaplan–Meier method and log-rank test showed widowed patients may lead to the highest mortality rate while married patients have a higher survival rate than the other three groups. Single and divorced or separated patients had no significant difference in the survival rate. In addition, multivariate analysis by controlling for confounding factors showed that in male, well-differentiated, and early stage patients, compared with married, unmarried was an independent risk factor for CSS (P < 0.05). Conclusion: Marital status showed a significant association with the survival status of LSCC patients. Importantly, the outcome of married patients was better, while widowed patients tended to have worse prognosis. [ABSTRACT FROM AUTHOR]