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Your search keyword '"Lanke, K.H.W."' showing total 2 results
Start Over Author "Lanke, K.H.W." Topic lnfectious diseases and global health radboud institute for health sciences [radboudumc 4]
2 results on '"Lanke, K.H.W."'

1. Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials

Author

Bastiaens, G.J.H., Tiono, A.B., Okebe, J., Pett, H.E., Coulibaly, Sam A., Goncalves, B.P., Lanke, K.H.W., Bousema, T., and Drakeley, C.

Subjects
All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
Abstract

Contains fulltext : 184044.pdf (Publisher’s version ) (Open Access)

Published
2018

2. Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR

Author

Schneider, P., Reece, S.E., Schaijk, B.C.L. van, Bousema, T., Lanke, K.H.W., Meaden, C.S., Gadalla, A., Ranford-Cartwright, L.C., and Babiker, H.A.

Subjects
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], parasitic diseases
Abstract

Contains fulltext : 153785.pdf (Publisher’s version ) (Open Access) The transmission of malaria parasites depends on the presence of sexual stages (gametocytes) in the blood, making the ratio and densities of female and male gametocytes important determinants of parasite fitness. This manuscript describes the development of reverse transcriptase quantitative PCR (RT-qPCR) assays to separately quantify mature female and male gametocytes of the human malaria parasite Plasmodium falciparum, and reveals that Pfs25 mRNA is expressed only in female gametocytes. The female (Pfs25) and male (Pfs230p) gametocyte specific RT-qPCR assays have lower detection limits of 0.3 female and 1.8 male gametocytes per microlitre of blood, respectively, making them more sensitive than microscopy. Accurate quantification of the ratio and densities of female and male gametocytes will increase understanding of P. falciparum transmission and improve the evaluation of transmission blocking interventions.

Published
2015

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