1. Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation.
- Author
-
Hayashi H, Takamura H, Ohbatake Y, Nakanuma S, Tajima H, Fushida S, Onishi I, Tani T, Shimizu K, and Ohta T
- Subjects
- Adult, Aged, Biomarkers blood, Female, Humans, Liver Transplantation methods, Lymphocyte Count, Male, Middle Aged, Outcome Assessment, Health Care, Platelet Count, Postoperative Period, Prognosis, Retrospective Studies, Survival Rate, Blood Platelets metabolism, Liver Transplantation mortality, Living Donors, Lymphocytes metabolism, Neutrophils metabolism
- Abstract
Background/objective: The neutrophil-to-lymphocyte ratio (NLR) is a simple index that represents systemic inflammatory change. The number of platelets is also known to reflect both post-transplant graft regeneration and dysfunction. Thus, we aimed to investigate the usefulness of NLR and platelet number in predicting the clinical course after adult-to-adult living donor liver transplantation (AA-LDLT) in the acute postoperative period in recipients., Methods: Between January 1999 and December 2013, 61 patients underwent their first AA-LDLT at our institute. We retrospectively analyzed their clinical data, including NLR and number of platelets, until postoperative day 14, and evaluated their ability to predict prognosis after AA-LDLT., Results: The optimal cutoff values of postoperative maximum NLR and maximum platelets to predict prognosis were 50 and 80 × 10
3 /μL, respectively. The 1- and 5-year survival rates were 87.5% and 79.1% in the normal maximum NLR group, respectively, and 46.2% for both in the high maximum NLR group (p = 0.0033). The 1- and 5-year survival rates, respectively, were 90.9% and 84.1% in the high maximum platelets group and 47.1% and 41.2% in the low maximum platelets group (p < 0.0001). In multivariate analysis, maximum NLR ≥ 50 and maximum platelets < 80 × 103 /μL were independently associated with 1-year mortality., Conclusion: A high NLR and a low platelet count during acute postoperative period might correlate with poor prognosis after AA-LDLT., (Copyright © 2017. Published by Elsevier Taiwan LLC.)- Published
- 2018
- Full Text
- View/download PDF