1. The influence of OKT3 therapy on hepatocellular carcinoma recurrence following liver transplantation.
- Author
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Zimmerman MA, Kelly MA, Campsen J, Mandell MS, Wachs M, Bak T, Skibba A, Lancaster B, and Kam I
- Subjects
- Carcinoma, Hepatocellular pathology, Female, Humans, Liver Neoplasms pathology, Male, Middle Aged, Retrospective Studies, Survival Rate, Treatment Outcome, Carcinoma, Hepatocellular therapy, Immunosuppressive Agents therapeutic use, Liver Neoplasms therapy, Liver Transplantation, Muromonab-CD3 therapeutic use, Neoplasm Recurrence, Local epidemiology
- Abstract
Introduction: Cancer recurrence following orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) is a significant obstacle in up to 10-20% of recipients. Recent evidence suggests that anti-CD3 antibody (OKT3) therapy may be associated with increased rates of HCC recurrence., Methods: At the University of Colorado Transplant Center, 173 patients underwent OLT for end-stage liver disease with concomitant HCC between 1997 and 2008. Nine clinical and pathologic variables were analyzed to test the association between OKT3 therapy for steroid-resistant rejection (SRR) and HCC recurrence-free survival., Results: Overall, the rate of HCC recurrence in this cohort was low and comparable across treatment groups (8.7%). Multivariate analysis reveals that increasing tumor diameter and differentiation have a negative impact on HCC recurrence-free survival., Conclusions: While several pathologic variables appear to influence outcome, we found no association between OKT3 therapy for SRR and HCC recurrence or survival., (© 2009 John Wiley & Sons A/S.)
- Published
- 2010
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