86 results on '"Hepatic Angiosarcoma"'
Search Results
2. Mesenchymal Neoplasms of the Liver.
- Author
-
Papke DJ Jr
- Subjects
- Humans, Liver Neoplasms diagnosis, Liver Neoplasms pathology, Hemangiosarcoma pathology, Hemangioma pathology, Sarcoma pathology, Soft Tissue Neoplasms, Hamartoma pathology
- Abstract
Mesenchymal neoplasms of the liver can be diagnostically challenging, particularly on core needle biopsies. Here, I discuss recent updates in neoplasms that are specific to the liver (mesenchymal hamartoma, undifferentiated embryonal sarcoma, calcifying nested stromal-epithelial tumor), vascular tumors of the liver (anastomosing hemangioma, hepatic small vessel neoplasm, epithelioid hemangioendothelioma, angiosarcoma), and other tumor types that can occur primarily in the liver (PEComa/angiomyolipoma, inflammatory pseudotumor-like follicular dendritic cell sarcoma, EBV-associated smooth muscle tumor, inflammatory myofibroblastic tumor, malignant rhabdoid tumor). Lastly, I discuss metastatic sarcomas to the liver, as well as pitfalls presented by metastatic melanoma and sarcomatoid carcinoma., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
3. Cytomorphologic and immunocytochemical diagnosis of primary hepatic angiosarcoma in a young adult: Challenging diagnosis of a rare, aggressive malignancy.
- Author
-
Gupta P, Singh B, Chaluvashetty SB, Gupta N, Kalra N, Duseja A, and Behera A
- Subjects
- Male, Humans, Immunohistochemistry, Biomarkers, Tumor, Diagnosis, Differential, Hemangiosarcoma diagnosis, Hemangiosarcoma pathology, Liver Neoplasms diagnosis, Liver Neoplasms pathology
- Abstract
Primary hepatic angiosarcoma (PHA) is a rare, rapidly growing, highly aggressive hepatic malignancy, primarily seen in elderly males. Establishing an accurate clinical diagnosis is challenging owing to its rarity and nonspecific presentation. Rendering a cytologic diagnosis of PHA is extremely difficult, and immunocytochemistry(ICC) on cell block(CB) sections is essential to confirm the diagnosis. The characteristic cytomorphologic features of PHA have rarely been documented, further augmenting the diagnostic challenge. A 32-year-old male presented with abdominal pain, abdominal distension, and significant weight loss over the past 9 months. On examination, the abdomen was distended, with multiple spider angiomas and a large mass in the right hypochondrium. His renal function tests, liver function tests, and serum tumor markers were within normal limits. An abdominal triphasic computerized tomography revealed a large lobulated mass in the right lobe with central necrosis. An ultrasound-guided FNA was performed from the liver lesion. The cytologic smears showed singly scattered large, markedly pleomorphic, epithelioid-elongated tumor cells having oval-elongated nuclei, irregular nuclear contours, coarse chromatin, prominent macronucleoli, and abundant finely vacuolated cytoplasm in a background of blood. ICC on the CB demonstrated diffuse positivity for vimentin, CD31, and nuclear positivity for FLI-1, confirming a vascular origin. Hence, a final cytologic diagnosis of primary hepatic angiosarcoma was rendered. The index report describes the characteristic cytomorphologic and immunocytochemical features of a rare hepatic malignancy in a young male and reiterates the usefulness of FNAC coupled with CB-ICC in the quick and precise diagnosis of such challenging cases., (© 2022 Wiley Periodicals LLC.)
- Published
- 2023
- Full Text
- View/download PDF
4. Primary Hepatic Angiosarcoma: A Rare and Very Aggressive Liver Tumour.
- Author
-
Durmaz S, Basak M, Ozguven BY, Eken KG, and Erturk SM
- Subjects
- Male, Humans, Middle Aged, Magnetic Resonance Imaging methods, Liver Neoplasms diagnostic imaging, Liver Neoplasms complications, Carcinoma, Hepatocellular, Hemangiosarcoma diagnostic imaging, Hemangiosarcoma surgery
- Abstract
Primary hepatic angiosarcoma (PHA) is a sporadic and aggressive tumour of the liver that originates from mesenchymal cells and represents less than 2% of all primary liver tumours. It is known to be associated with several environmental and industrial carcinogens; however, in 75% of cases, aetiology remains unclear. Patients generally present with nonspecific symptoms and laboratory findings. Imaging has a limited role in the diagnosis. We herein present a case of a 52-year-old man with a history of hepatitis B-related cirrhosis who was referred to our hospital for liver transplantation assessment. Magnetic resonance imaging (MRI) revealed two small nodular lesions of 5 and 6 mm in segment IV of the liver, categorised as Liver Imaging Reporting and Data System (LI-RADS) category 3. The patient was discussed at a multidisciplinary tumour meeting, and an MRI follow-up in three months was planned. Three months later, MRI depicted a substantial increase in the lesion size measured 8.5 cm. An ultrasound-guided tru-cut biopsy was performed, and the diagnosis of PHA was confirmed by pathology. In this report, we aim to highlight PHA's MRI features and underline this rare entity's rapid and fatal progression.
- Published
- 2022
- Full Text
- View/download PDF
5. Conversion surgery for recurrent hepatic angiosarcoma after systemic chemotherapy with paclitaxel.
- Author
-
Ushida Y, Sato T, Kato T, Shigematsu Y, Ito H, Suzuki T, Inoue Y, Ono Y, Oba A, and Takahashi Y
- Subjects
- Aged, Hepatectomy, Humans, Male, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local surgery, Paclitaxel, Hemangiosarcoma drug therapy, Hemangiosarcoma surgery, Liver Neoplasms drug therapy, Liver Neoplasms pathology, Liver Neoplasms surgery
- Abstract
A 67-year-old man presented with hemorrhagic shock due to the rupture of hepatic tumor and underwent emergency partial resection of the right liver. Pathological examination revealed hepatic angiosarcoma with involvement in its surgical margin. Six months after the operation, disease recurrence was detected, and he was referred to our hospital for second opinion. CT revealed tumors at the liver cut surface and left lateral segment. The tumor at the liver cut surface abutted to the common bile duct and the portal vein. The tumor was deemed unresectable, and systemic chemotherapy with 4 courses of weekly paclitaxel was given with excellent response. Then, we performed partial liver resection of S4 and S1 with remnant right liver and middle hepatic vein, and wedge resection for the metastatic lesion of segment 3 as a conversion surgery. He developed a grade B bile leakage postoperatively and was discharged on postoperative day 28. He remained disease free for 8 months after the operation., (© 2021. Japanese Society of Gastroenterology.)
- Published
- 2022
- Full Text
- View/download PDF
6. Case of Primary Hepatic Angiosarcoma Presenting With Jaundice and Infiltrative Liver Masses.
- Author
-
Shaaban A, Anugwom C, Habib A, Mettler T, Jaffer S, and Thomson M
- Subjects
- Biopsy, Humans, Hemangiosarcoma complications, Hemangiosarcoma diagnosis, Hemangiosarcoma pathology, Jaundice, Liver Neoplasms complications, Liver Neoplasms diagnosis, Liver Neoplasms pathology
- Abstract
Primary hepatic angiosarcoma (PHA) is a rare and aggressive mesenchymal liver tumor with a poor prognosis and high mortality. Treatment options are limited to palliative chemotherapy with surgical resection reserved for the few cases that present early. We present a case of a patient who presented with jaundice and elevated liver enzymes. Imaging identified a diffusely heterogeneous liver consistent with cirrhosis, findings of portal hypertension, and 2 ill-defined liver lesions. Biopsy results confirmed PHA. Primary hepatic angiosarcoma does not have a typical presentation but should be considered for any patient presenting with an infiltrative liver mass.
- Published
- 2022
- Full Text
- View/download PDF
7. Hepatic vascular malignancies in children are associated with increased rates of surgical resection and improved overall survival compared with adults.
- Author
-
Commander SJ, Cerullo M, Leraas HJ, Reed CR, Achey MA, Wachsmuth LP, Schooler GR, and Tracy ET
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Hemangioendothelioma, Epithelioid mortality, Hemangioendothelioma, Epithelioid surgery, Hemangiosarcoma mortality, Hemangiosarcoma surgery, Humans, Infant, Infant, Newborn, Liver Neoplasms mortality, Liver Neoplasms surgery, Male, Middle Aged, Young Adult, Hemangioendothelioma, Epithelioid pathology, Hemangiosarcoma pathology, Liver Neoplasms pathology
- Abstract
Background: Hepatic vascular malignancies (HVMs) are rare malignancies, with no standardized treatment regimens. The most common HVMs, angiosarcoma and malignant epithelioid hemangioendothelioma (EHE), are often grouped together in the literature complicating our ability to achieve reliable survival data and treatment strategies., Objective: To compare the disease characteristics of HVMs, with a subanalysis on pediatric patients., Methods: The 2016 National Cancer Database was queried for patients with HVMs using international classification of diseases-oncology-3 (ICD-O-3) codes yielding 699 patients. Descriptive statistics, chi-square, Kaplan-Meier, and log-rank analyses were performed., Results: We found 478 patients (68%) with angiosarcoma and 221 (32%) with EHE. The median (Q1, Q3) age for angiosarcoma patients was 65 years (56, 75) versus 54 years (37, 65) in EHE patients (P < .001). The rate of resection was lower in patients with angiosarcoma than EHE (13% vs 32%, P < .001). The mean 1-, 3-, and 5-year overall survival for angiosarcoma patients was 17%, 8%, and 6%, respectively, versus 80%, 65%, and 62% in EHE patients (P < .0001). A subgroup analysis was performed on pediatric patients demonstrating six with angiosarcoma and 10 with EHE. The mean 1-, 3-, and 5-year overall survival for pediatric angiosarcoma patients was 67%, 50%, and 50%, respectively, and 90%, 90%, and 90% for pediatric EHE patients., Conclusion: In the largest study of HVMs to date, we found angiosarcoma has significantly worse overall survival than EHE. Pediatric patients appear to have improved survival and higher rates of resection. Larger studies of HVMs are needed to clearly differentiate tumor types, standardize care, and improve survivorship., (© 2021 Wiley Periodicals LLC.)
- Published
- 2021
- Full Text
- View/download PDF
8. Long-term survival with complete resection in recurrent hepatic angiosarcoma.
- Author
-
Yamoto M, Koyama M, Iwafuchi H, Watanabe K, and Urushihara N
- Subjects
- Humans, Neoplasm Recurrence, Local, Prognosis, Survival Rate, Hemangiosarcoma, Liver Neoplasms
- Published
- 2020
- Full Text
- View/download PDF
9. Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review.
- Author
-
Zhang XM, Tong Y, Li Q, and He Q
- Subjects
- Fatal Outcome, Hemangiosarcoma pathology, Hemangiosarcoma surgery, Humans, Liver Failure etiology, Liver Failure surgery, Liver Neoplasms pathology, Liver Neoplasms surgery, Liver Transplantation, Male, Middle Aged, Hemangiosarcoma complications, Kasabach-Merritt Syndrome complications, Liver Neoplasms complications
- Abstract
Background: Hepatic angiosarcoma is a rare malignant tumor featured by highly aggressive behavior and poor prognosis. There are few reports about diffused hepatic angiosarcoma with Kasabach-Merritt syndrome till now., Case Presentation: A male patient with the chief complain of hepatic space-occupying lesion accompanied by disturbance of consciousness and jaundice. Hyperbilirubinemia, anemia, thrombocytopenia, prolonged prothrombin time, hypofibrinogenemia, decreased prothrombin activity, and increased fibrinogen degradation product and D-dimer were confirmed by blood analysis; multiple focal hypodense lesions in liver was detected by abdominal computed tomography. Liver failure and Kasabach-Merritt syndrome induced by hepatic hemangioma was diagnosed before operation and liver transplantation was performed. Hepatic angiosarcoma was finally proven by postoperative pathology. This patient died of tumor metastasis 2 months after operation., Conclusions: Hepatic angiosarcoma which can generate Kasabach-Merritt syndrome and even liver failure has an extremely poor prognosis; liver transplantation option should not be considered in hepatic angiosarcoma regardless of the reason.
- Published
- 2020
- Full Text
- View/download PDF
10. Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report.
- Author
-
Pilbeam K, Eidenschink B, Sulciner M, Luquette M, Neglia J, and Chinnakotla S
- Subjects
- Biopsy, Child, Preschool, Docetaxel administration & dosage, Doxorubicin administration & dosage, Female, Humans, Ifosfamide administration & dosage, Liver diagnostic imaging, Neoplasm Recurrence, Local, Treatment Outcome, Antineoplastic Agents pharmacology, Hemangiosarcoma surgery, Liver Neoplasms surgery, Liver Transplantation
- Abstract
Hepatic angiosarcoma is an extremely rare diagnosis in children, with fewer than 50 pediatric cases reported in the literature worldwide. This aggressive vascular sarcoma carries a very dismal prognosis and is known to be resistant to radiation, chemotherapy, and other vascular-targeted agents. Complete surgical resection is felt to provide the best chance for long-term survival. In patients with tumors not amenable to resection, a liver transplant can be considered. However, very few such transplants have been reported, given that they remain controversial due to high cancer recurrence and mortality post-transplant. Herein, we report the unique case of a 2-year-old child with localized hepatic angiosarcoma not amendable to resection who successfully underwent a liver transplant and received chemotherapy with six cycles of doxorubicin, docetaxel, and ifosfamide., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
11. A pooled analysis of treatment and prognosis of hepatic angiosarcoma in adults.
- Author
-
Li DB, Si XY, Wan T, and Zhou YM
- Subjects
- Adult, Aged, Antineoplastic Agents adverse effects, Clinical Decision-Making, Female, Hemangiosarcoma mortality, Hemangiosarcoma pathology, Humans, Kaplan-Meier Estimate, Liver Neoplasms mortality, Liver Neoplasms pathology, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Time Factors, Treatment Outcome, Tumor Burden, Antineoplastic Agents therapeutic use, Hemangiosarcoma therapy, Hepatectomy adverse effects, Hepatectomy mortality, Liver Neoplasms therapy, Liver Transplantation adverse effects, Liver Transplantation mortality
- Abstract
Background: Hepatic angiosarcoma is a rare malignant vascular tumor presenting unique treatment challenges. The aim of the present study was to determine the treatment and prognosis of this entity., Data Sources: A systematic literature search was conducted using PubMed, Embase and Chinese Biomedical Literature database, to identify articles published from January 1980 to July 2017. Search terms were "hepatic angiosarcoma" and "liver angiosarcoma". Additional articles were retrieved through manual search of bibliographies of the relevant articles. Pooled individual data concerning the prognosis following various therapeutic modalities were analyzed., Results: A total of 75 articles involving 186 patients were eligible for inclusion. The median overall survival (OS) was 8 months, with 1-, 3-, and 5-year OS rates of 36.6%, 22.3%, and 12.0%, respectively. The median OS after partial hepatectomy (n = 86), chemotherapy (n = 36), liver transplantation (n = 17), and supportive care (n = 46) were 15, 10, 5 and 1.3 months, respectively. Small tumor size (<10 cm) was the only significant favorable factor for OS after partial hepatectomy (P = 0.012)., Conclusions: Despite the dismal prognosis, partial hepatectomy could prolong the survival of hepatic angiosarcoma patients, particularly those with tumors <10 cm. Chemotherapy could be an option for unresectable disease. Liver transplantation is not a recommendable option for the management of this malignancy., (Copyright © 2018. Published by Elsevier B.V.)
- Published
- 2018
- Full Text
- View/download PDF
12. Clinical case series of pediatric hepatic angiosarcoma.
- Author
-
Grassia KL, Peterman CM, Iacobas I, Margolin JF, Bien E, Padhye B, Meyers RL, and Adams DM
- Subjects
- Child, Preschool, Female, Hemangiosarcoma therapy, Humans, Liver Neoplasms therapy, Liver Transplantation, Male, Prognosis, Hemangiosarcoma pathology, Liver Neoplasms pathology
- Abstract
Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a "vascular tumor." Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low-grade form of angiosarcoma rather than a benign lesion., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2017
- Full Text
- View/download PDF
13. Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome.
- Author
-
Wadhwa S, Kim TH, Lin L, Kanel G, and Saito T
- Subjects
- Adult, Humans, Kasabach-Merritt Syndrome pathology, Liver pathology, Liver Neoplasms pathology, Male, Kasabach-Merritt Syndrome diagnosis, Liver Neoplasms diagnosis
- Abstract
Hepatic angiosarcoma is a mesenchymal tumor originating from liver sinusoidal endothelial cells. It is an extremely rare malignant neoplasm accounting for less than 1% of primary malignant liver tumors. The deregulated coagulopathy that can be seen in hepatic angiosarcoma fulfills the clinical diagnostic criteria of disseminated intravascular coagulation. However, the mechanism that governs this coagulopathy has been poorly understood. This case report provides histological evidence of the consumption of coagulation factors along with trapped platelets occurring within the tumor, which is the foundation for the concept of Kasabach-Merritt syndrome (KMS). KMS is characterized by thrombocytopenia and hyperconsumption of coagulation factors within a vascular tumor. However, KMS associated with angiosarcoma has not been well recognized. This case report describes, for the first time, the histological evidence of KMS that occurred in an extremely rare mesenchymal malignant tumor of the liver., Competing Interests: Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
- Published
- 2017
- Full Text
- View/download PDF
14. [Hepatic angiosarcoma and liver transplantation: case report and literature review].
- Author
-
Huerta-Orozco LD, Leonher-Ruezga KL, Ramírez-González LR, Hermosillo-Sandoval JM, Sandoval-Alvarado Jde J, and Morán-Galaviz RE
- Subjects
- Abdominal Pain etiology, Adult, Embolization, Therapeutic, Fatal Outcome, Hemangioma, Cavernous diagnosis, Hemangiosarcoma complications, Hemangiosarcoma diagnosis, Hemangiosarcoma secondary, Hemoperitoneum etiology, Hemoptysis etiology, Humans, Liver Neoplasms complications, Liver Neoplasms diagnosis, Lung Neoplasms complications, Lung Neoplasms secondary, Male, Postoperative Complications, Rupture, Spontaneous, Tomography, X-Ray Computed, Diagnostic Errors, Hemangiosarcoma surgery, Liver Neoplasms surgery, Liver Transplantation
- Abstract
Background: Hepatic angiosarcoma is a rare vascular malignancy that accounts for 2% of all hepatic primary tumours. The diagnosis is difficult, especially if the patient does not have history of exposure to carcinogens, which are considered as risk factors. The diagnosis is made by histopathology, but in a considerable percentage it can only be accomplished by autopsy. The performing of fine needle aspiration biopsy can lead to bleeding, with limitations in its use., Clinical Case: A 41 year-old male, with no history of exposure to carcinogens, who developed abdominal pain secondary to a haemoperitoneum due to tumour rupture, was diagnosed by imaging methods with a giant cavernous hepatic haemangioma. He was initially treated with embolisation, and later with a liver transplant. After six months he developed haemoptysis secondary to lung metastasis. The autopsy reported metastatic hepatic angiosarcoma., Discussion: This condition has been related to carcinogen exposure, with malignant transformation from a benign vascular neoplasia being proposed as a hypothesis. The differential diagnosis can be achieved with imaging studies such as CT scan, and the definitive diagnosis is made by histopathology with immunohistochemistry tests, with 35%-100% being made in the autopsy., Conclusion: Hepatic angiosarcoma is a malignant vascular neoplasia, the potential curative option is surgery with tumour free margins. Liver transplantation remains controversial because of its poor prognosis in the short term., (Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
15. Clinical courses of primary hepatic angiosarcoma: retrospective analysis of eight cases.
- Author
-
Hur CJ, Min BR, Lee YJ, Jang BK, Hwang JS, Kim ES, Park KS, Cho KB, Kang YN, and Chung WJ
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Embolization, Therapeutic, Female, Hemangiosarcoma pathology, Hemangiosarcoma therapy, Humans, Immunohistochemistry, Liver Neoplasms pathology, Liver Neoplasms therapy, Male, Middle Aged, Neoplasm Metastasis, Prognosis, Retrospective Studies, Survival Rate, Tomography, X-Ray Computed, Hemangiosarcoma diagnosis, Liver Neoplasms diagnosis
- Abstract
Background/aims: Hepatic angiosarcoma, a rare and aggressive liver malignancy, is difficult to diagnose because of a lack of specific clinical features. The clinical and radiological features of patients with histologically confirmed hepatic angiosarcoma were examined., Methods: Among 2,336 patients diagnosed with primary hepatic carcinoma at Keimyung University Dongsan Medical Center (Daegu, Korea) between May 2002 and February 2012, eight (0.03%) with histologically confirmed primary hepatic angiosarcoma were included. The patterns of disease diagnosis, tumor characteristics, treatment responses, and prognoses were reviewed retrospectively., Results: Median age was 66 years-old (range, 41-80 years). Four patients were male. Five patients were compulsive drinkers. All patients had no HBsAg and anti-HCV. Initial radiologic diagnoses revealed primary hepatic angiosarcoma (n=2), hepatocellular carcinoma (n=2), hemangioma (n=2), and hepatic metastatic carcinoma (n=2). Definitive diagnoses were made by percutaneous needle biopsies in seven patients and surgical resection in one patient. At the time of the initial diagnosis, extrahepatic metastases were detected in three patients (37.5%). Metastatic sites included the spleen and lung, pericardium, and bone, in one patient each. Two patients underwent conservative treatments. The remaining patients underwent surgical resection (n=1), transcatheter arterial chemoembolization (n=1), and systemic chemotherapy (n=4). The median survival period was 214 days (range, 21-431 days)., Conclusions: Hepatic angiosarcoma is a highly progressive disease with a poor prognosis. Detailed studies including histological examinations are essential to facilitate early diagnosis of the disease.
- Published
- 2015
- Full Text
- View/download PDF
16. A ruptured 200‐mm primary hepatic angiosarcoma: A case report
- Author
-
Megan Alderuccio, Val Usatoff, George Harisis, June Oo, and Samantha Ellis
- Subjects
medicine.medical_specialty ,Rupture, Spontaneous ,business.industry ,Hemangiosarcoma ,Liver Neoplasms ,MEDLINE ,Humans ,Medicine ,Surgery ,General Medicine ,Hepatic Angiosarcoma ,Radiology ,business - Published
- 2021
17. Sinusoidal Hepatic Angiosarcoma on a Background of Non-cirrhotic Portal Hypertension and Nodular Regenerative Hyperplasia Masquerading as Acute on Chronic Liver Failure
- Author
-
Mohamed Rela, Ilankumaran Kaliamoorthy, Mukul Vij, Abdul Hakeem, Vaibhav Patil, and Mettu Srinivas Reddy
- Subjects
Male ,medicine.medical_specialty ,Hyperplasia ,business.industry ,medicine.medical_treatment ,Hemangiosarcoma ,Liver Neoplasms ,Gastroenterology ,MEDLINE ,Acute-On-Chronic Liver Failure ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Liver Transplantation ,Radiation therapy ,Oncology ,Internal medicine ,Hypertension, Portal ,medicine ,Humans ,Portal hypertension ,Acute on chronic liver failure ,business ,Nodular regenerative hyperplasia - Published
- 2020
18. Contrast-enhanced computed tomography features of a rare case of cystic primary hepatic angiosarcoma
- Author
-
Jin-Yuan Liao, Lan-Hui Qin, and Pei-Yin Chen
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,media_common.quotation_subject ,Hemangiosarcoma ,Liver Neoplasms ,Computed tomography ,Hepatic Angiosarcoma ,Rare case ,Internal Medicine ,Humans ,Contrast (vision) ,Medicine ,Radiology ,Tomography, X-Ray Computed ,business ,media_common - Published
- 2021
19. Is primary hepatic angiosarcoma in children an indication for liver transplantation?-A single-centre experience and review of the literature
- Author
-
Afrodite Psaros Einberg, Thomas Casswall, Fredrik Baecklund, Bo-Göran Ericzon, Josefin Aldén, Sandra Wessman, and Greg Nowak
- Subjects
Transplantation ,Chemotherapy ,Pediatrics ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Hemangiosarcoma ,Liver Neoplasms ,Treatment options ,Infant ,chemical and pharmacologic phenomena ,Malignant Soft Tissue Neoplasm ,Hepatic Angiosarcoma ,Liver transplantation ,University hospital ,Liver Transplantation ,Single centre ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Female ,Good outcome ,business - Abstract
PHA in the paediatric population is an extremely rare and aggressive malignant soft tissue neoplasm, with less than 50 cases published worldwide. The prognosis is dismal. If the tumour is unresectable, one treatment option is LT. In this article, the current available literature is reviewed and additionally, three cases of paediatric patients with PHA who underwent LT at Karolinska University Hospital, Sweden, are presented. Based on the literature and our own experience, there is undoubtedly possible good outcome of LT due to PHA. On the contrary, no patients have survived PHA without LT. PHA in paediatric patients should be recommended to LT in selected patients. Effect of modern adjuvant chemo and RT should be evaluated further based on international registry for such rare cases of PHA.
- Published
- 2021
20. Melena as a first sign of metastatic hepatic angiosarcoma: A case report
- Author
-
Marjan Micev, Vera Matovic, Srdjan Djuranovic, Miodrag Krstic, Tijana Glisic, Ljubisa Toncev, and Aleksandra Sokic-Milutinovic
- Subjects
medicine.medical_specialty ,lcsh:R5-920 ,palliative care ,liver neoplasms ,business.industry ,Hepatic Angiosarcoma ,03 medical and health sciences ,hemangiosarcoma ,diagnostic techniques and procedures ,0302 clinical medicine ,Melena ,melena ,030220 oncology & carcinogenesis ,Medicine ,diagnosis, differential ,030211 gastroenterology & hepatology ,Pharmacology (medical) ,Radiology ,medicine.symptom ,business ,lcsh:Medicine (General) ,Sign (mathematics) - Abstract
Introduction. Angiosarcomas are malignant tumors of vascular endothelium that may arise from different locations. Although primary hepatic angiosarcoma accounts for only 1.8% of primary liver tumors, it is the most common malignant mesenchymal tumor of the liver. We report a case of primary hepatic angiosarcoma with melena as an unusual initial manifestation of this extremely rare tumor. Case report. Forty-four-years old patient with melena was referred to our Clinic because melena was not resolved after repeated argon plasma coagulation of bleeding lesions during esophagogastroduodenoscopy in the regional hospital. Abdominal ultrasound and multislice computed tomography (MSCT) revealed enlarged liver, with focal lesion 6 cm in diameter localized in the left lobe with multiple satellite lesions in both liver lobes, enlarged spleen and extremely dilated and long umbilical vein. Double-balloon enteroscopy and video capsule endoscopy detected the multiple bleeding vascular lesions in the small bowel. Histopathological examination and immunohistochemistry of the small bowel lesions revealed malignant mesenchymal proliferation with vascular/endothelium differentiation of neoplastic cells. The patient was diagnosed with metastatic angiosarcoma probably of hepatic origin with metastasis in the small bowel, that caused melena, and in the lumbar spine, causing back pain. Conclusion. Rare causes of melena include bleeding from primary or metastatic hemangiosarcoma localized in the gastrointestinal tract, especially small bowel.
- Published
- 2019
21. Clinical characteristics and surgical treatments of primary hepatic angiosarcoma
- Author
-
Hang Xie, Lei Jiang, Xinran Cai, Ge Li, Yan-Ling Chen, Lijun Xie, and Zhao Fang
- Subjects
Abdominal pain ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hemangiosarcoma ,Clinical manifestation ,Transarterial chemoembolization ,030218 nuclear medicine & medical imaging ,Serology ,03 medical and health sciences ,0302 clinical medicine ,Hepatic lobectomy ,Internal medicine ,medicine ,Humans ,lcsh:RC799-869 ,Chemoembolization, Therapeutic ,Primary hepatic angiosarcoma ,Retrospective Studies ,Clinical characteristics ,business.industry ,Liver Neoplasms ,Gastroenterology ,General Medicine ,Hepatic Angiosarcoma ,Hepatitis B ,Hepatology ,medicine.disease ,Pneumonia ,Surgical treatments ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,Radiology ,medicine.symptom ,business ,Research Article - Abstract
Purpose Primary hepatic angiosarcoma is a very rare and highly malignant tumor with poor prognosis. It is difficult to diagnose because of the lack of typical clinical features, and the treatment protocols for PHA are also not clear. Therefore, this study wants to find out the clinical characteristics and surgical treatments of primary hepatic angiosarcoma. Methods Among 8990 patients diagnosed with primary malignant tumor of the liver from January 2000 to December 2019 in our hospital, only four patients were diagnosed with primary hepatic angiosarcoma. The demographics, clinical manifestation, past history, serology test results, MRI features, pathology, treatment modality and prognosis of four patients were collected and analyzed. Results Three of four patients had no clinical symptoms, while one patient's symptom was abdominal pain. The levels of tumor markers of all four patients were within the normal reference range and serological tests were negative for hepatitis B and C virus. The MRI imaging findings of all four patients were mixed mass with highly disordered vascular characteristics. All four patients were misdiagnosed preoperatively. One patient who underwent hepatic lobectomy was still alive for about 18 months after surgery. One patient who underwent hepatic lobectomy has survived for only 6 months due to severe pneumonia. The other two patients who received transarterial chemoembolization survived 16 months and 11 months respectively. Conclusion The clinical symptoms of primary hepatic angiosarcoma are not typical, and primary hepatic angiosarcoma is easily misdiagnosed. The typical imaging manifestations are structural disorder and heterogeneous tumor. Hepatic lobectomy and transarterial chemoembolization may be important surgical treatments to improve the prognosis of patients.
- Published
- 2021
22. Multifocal Hepatic Angiosarcoma with Atypical Presentation: Case Report and Literature Review
- Author
-
Maria Gaia Mastrosimini, Paola Capelli, Sara Pecori, Andrea Ruzzenente, Enrico Cavallo, Anna Caliò, Matteo Brunelli, Mirko D'Onofrio, Andrea Dalbeni, Stefano Marletta, Lavinia Stefanizzi, and Serena Ammendola
- Subjects
Male ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General surgery ,Vinyl chloride monomer ,Hemangiosarcoma ,Liver Neoplasms ,Gastroenterology ,case report, Hepatic angiosarcoma, Vinyl chloride monomer, Polyvinyl chloride ,Polyvinyl chloride ,Hepatic Angiosarcoma ,Hepatic angiosarcoma ,Radiation therapy ,Fatal Outcome ,Oncology ,medicine ,Humans ,case report ,Autopsy ,Presentation (obstetrics) ,business ,Aged - Published
- 2021
23. Long-term survival with complete resection in recurrent hepatic angiosarcoma
- Author
-
Kenichiro Watanabe, Naoto Urushihara, Masashi Koyama, Masaya Yamoto, and Hideto Iwafuchi
- Subjects
medicine.medical_specialty ,business.industry ,Hemangiosarcoma ,Liver Neoplasms ,MEDLINE ,Hepatic Angiosarcoma ,Prognosis ,Complete resection ,Surgery ,Survival Rate ,Pediatrics, Perinatology and Child Health ,Long term survival ,Medicine ,Humans ,Neoplasm Recurrence, Local ,business - Published
- 2020
24. Hypertrophic Osteoarthropathy in a Patient With Primary Hepatic Angiosarcoma
- Author
-
Zhanxiong Yi, Jun Zhang, Congcong Yu, and Meng-Jie Dong
- Subjects
medicine.medical_specialty ,Technetium Tc 99m Medronate ,Hemangiosarcoma ,Physical examination ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Spinal osteoarthropathy ,Positron Emission Tomography Computed Tomography ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,medicine.diagnostic_test ,Dry cough ,business.industry ,Digital Clubbing ,Liver Neoplasms ,Osteoarthropathy, Secondary Hypertrophic ,General Medicine ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Hypertrophic osteoarthropathy ,body regions ,Bone scintigraphy ,030220 oncology & carcinogenesis ,Female ,Radiology ,Radiopharmaceuticals ,business - Abstract
Primary hepatic angiosarcoma was diagnosed in a 59-year-old woman who presented an arthralgia of limbs and dry cough for 6 weeks. Physical examination revealed digital clubbing. A Tc-MDP bone scintigraphy showed diffusely increased uptake along the cortical margins of long bones, suggesting hypertrophic osteoarthropathy.
- Published
- 2019
25. CAMTA-1 Expression in 24 Cases of Hepatic Epithelioid Hemangioendothelioma in a Single Institute: Diagnostic Utility for Differential Diagnosis from Hepatic Angiosarcoma
- Author
-
Han-Na Kim, Sangyun Ha, Hera Jung, Yunjeong Jang, and Cheol-Keun Park
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Hemangiosarcoma ,Gene Expression ,TFE3 ,General Biochemistry, Genetics and Molecular Biology ,Diagnosis, Differential ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Biopsy ,medicine ,Biomarkers, Tumor ,Humans ,Angiosarcoma ,Epithelioid hemangioendothelioma ,In Situ Hybridization, Fluorescence ,Aged ,Pharmacology ,medicine.diagnostic_test ,business.industry ,Calcium-Binding Proteins ,Liver Neoplasms ,Cancer ,Disease Management ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Treatment Outcome ,030220 oncology & carcinogenesis ,Trans-Activators ,Hemangioendothelioma, Epithelioid ,Female ,Differential diagnosis ,business ,Research Article - Abstract
Background/aim Epithelioid hemangio-endothelioma (EHE) of the liver is an uncommon vascular tumor with variable clinical courses ranging from stable disease to fatal outcome. EHE can mimic epithelioid angiosarcoma, which has a more aggressive behavior, especially in a small biopsy sample. EHEs are known to have the WWTR1-CAMTA1 fusion gene, and nuclear expression of CAMTA1 by immunohistochemistry (IHC) has been reported in about 90% of EHEs in multiple organs. Our study aimed to validate the diagnostic utility of CAMTA1 expression in EHEs, especially in the liver. Patients and methods IHC was performed using anti-CAMTA1 antibody in 34 tumors (24 hepatic EHEs and 10 angiosarcomas). In CAMTA1-negative EHEs, TFE3 IHC was performed. Results Of the 24 hepatic EHEs, 22 (91.6%) showed nuclear staining for CAMTA1. One of two CAMTA1-negative cases showed TFE3 positivity. The other case was negative for TFE3. Meanwhile, all 10 angiosarcoma cases had no CAMTA1 expression. Conclusion CAMTA1 is a highly sensitive and specific marker for diagnosis of hepatic EHE. It is helpful for differentiation of hepatic EHE and angiosarcoma, especially in small biopsy samples.
- Published
- 2019
26. A pooled analysis of treatment and prognosis of hepatic angiosarcoma in adults
- Author
-
Xiaoying Si, Yanming Zhou, Debang Li, and Tao Wan
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Clinical Decision-Making ,Hemangiosarcoma ,Antineoplastic Agents ,Kaplan-Meier Estimate ,Liver transplantation ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Hepatectomy ,Humans ,Aged ,Proportional Hazards Models ,Chemotherapy ,Hepatology ,Tumor size ,business.industry ,Liver Neoplasms ,Gastroenterology ,Hepatic Angiosarcoma ,Malignant Vascular Tumor ,Middle Aged ,Liver Transplantation ,Tumor Burden ,Treatment Outcome ,Pooled analysis ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,business ,Liver Angiosarcoma - Abstract
Hepatic angiosarcoma is a rare malignant vascular tumor presenting unique treatment challenges. The aim of the present study was to determine the treatment and prognosis of this entity.A systematic literature search was conducted using PubMed, Embase and Chinese Biomedical Literature database, to identify articles published from January 1980 to July 2017. Search terms were "hepatic angiosarcoma" and "liver angiosarcoma". Additional articles were retrieved through manual search of bibliographies of the relevant articles. Pooled individual data concerning the prognosis following various therapeutic modalities were analyzed.A total of 75 articles involving 186 patients were eligible for inclusion. The median overall survival (OS) was 8 months, with 1-, 3-, and 5-year OS rates of 36.6%, 22.3%, and 12.0%, respectively. The median OS after partial hepatectomy (n = 86), chemotherapy (n = 36), liver transplantation (n = 17), and supportive care (n = 46) were 15, 10, 5 and 1.3 months, respectively. Small tumor size (10 cm) was the only significant favorable factor for OS after partial hepatectomy (P = 0.012).Despite the dismal prognosis, partial hepatectomy could prolong the survival of hepatic angiosarcoma patients, particularly those with tumors10 cm. Chemotherapy could be an option for unresectable disease. Liver transplantation is not a recommendable option for the management of this malignancy.
- Published
- 2018
27. Surgically Diagnosed Primary Hepatic Angiosarcoma
- Author
-
Urara Baba, Shuichi Muto, Yoko Taya, Seiji Tsunematsu, Tomoaki Naka, Rui Sasaki, Hiroki Oi, Toshio Kimura, Yuki Tsukamoto, Yukio Ohara, Kazuhito Uemura, and Takashi Kitagataya
- Subjects
Surgical resection ,medicine.medical_specialty ,diagnosis ,Treatment outcome ,Case Report ,hepatosarcoma ,hemangiosarcoma ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,Internal Medicine ,medicine ,Humans ,Effective treatment ,primary hepatic angiosarcoma ,Good outcome ,neoplasms ,Aged ,business.industry ,Liver Neoplasms ,Advanced stage ,surgical resection ,General Medicine ,Hepatic Angiosarcoma ,medicine.disease ,digestive system diseases ,Rare tumor ,Treatment Outcome ,Hemangiosarcoma ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Radiology ,business - Abstract
Primary hepatic angiosarcoma is a rare tumor originating from endothelial cells in the liver and accounts for approximately 1% of all hepatic malignant tumors. It is difficult to diagnose due to the lack of specific symptoms or tumor markers. No effective treatment exists, but complete surgical resection may achieve a good outcome. Since most primary hepatic angiosarcomas are already at an advanced stage at diagnosis, few reports describe tumors smaller than 2 cm. We report a case of surgery for a 1.7-cm sized primary hepatic angiosarcoma. Further studies are required to improve the preoperative diagnosis of primary hepatic angiosarcoma.
- Published
- 2018
28. Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome
- Author
-
Tae Hun Kim, Leah Lin, Sanya Wadhwa, Gary Kanel, and Takeshi Saito
- Subjects
Kasabach-Merritt syndrome ,Adult ,Male ,Pathology ,medicine.medical_specialty ,Case Report ,Kasabach–Merritt syndrome ,Hepatic angiosarcoma ,Vascular tumor ,03 medical and health sciences ,0302 clinical medicine ,Coagulopathy ,medicine ,Humans ,Platelet ,Angiosarcoma ,Disseminated intravascular coagulation ,business.industry ,Liver Neoplasms ,Gastroenterology ,General Medicine ,Hepatic Angiosarcoma ,medicine.disease ,Coagulation ,Liver ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business - Abstract
Hepatic angiosarcoma is a mesenchymal tumor originating from liver sinusoidal endothelial cells. It is an extremely rare malignant neoplasm accounting for less than 1% of primary malignant liver tumors. The deregulated coagulopathy that can be seen in hepatic angiosarcoma fulfills the clinical diagnostic criteria of disseminated intravascular coagulation. However, the mechanism that governs this coagulopathy has been poorly understood. This case report provides histological evidence of the consumption of coagulation factors along with trapped platelets occurring within the tumor, which is the foundation for the concept of Kasabach-Merritt syndrome (KMS). KMS is characterized by thrombocytopenia and hyperconsumption of coagulation factors within a vascular tumor. However, KMS associated with angiosarcoma has not been well recognized. This case report describes, for the first time, the histological evidence of KMS that occurred in an extremely rare mesenchymal malignant tumor of the liver.
- Published
- 2017
29. Contrast-enhanced ultrasound in diagnosis of primary hepatic angiosarcoma
- Author
-
Wenwu Ling, Tingting Qiu, Lin Ma, Chuanfen Lei, and Yan Luo
- Subjects
Surgical resection ,Pathology ,medicine.medical_specialty ,Poor prognosis ,Hemangiosarcoma ,Contrast Media ,Enhancement pattern ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Ultrasonography ,business.industry ,Liver Neoplasms ,Ultrasound ,General Medicine ,Hepatic Angiosarcoma ,Liver ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Female ,Radiology ,business ,Contrast-enhanced ultrasound - Abstract
Primary hepatic angiosarcoma (PHA) is a rare malignant tumor that occurs mainly in the elderly, with almost no specific symptoms or tumor markers. Information on the imaging characteristics of this tumor is limited due to its rarity. Therefore, it is difficult to diagnose PHA. So far, its definite diagnosis depends on histopathologic examination combined with immunohistochemical results. Patients with PHA have a poor prognosis in spite of surgical resection of this tumor. In this case report, we present a 72-year-old woman with PHA, focusing on the imaging features of this tumor, especially its enhancement pattern on contrast-enhanced ultrasound images. Contrast-enhanced ultrasound provided helpful information for diagnosis.
- Published
- 2016
30. Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs
- Author
-
Eva M. Hofer, Nicole Golob-Schwarzl, Christina S. Schultheiss, Hans-Jörg Mischinger, Jessica Hoppstädter, Bettina Leber, Carolin Lackner, Bernadette Liegl-Atzwanger, Sonja M. Kessler, Johannes Haybaeck, and Philipp Stiegler
- Subjects
0301 basic medicine ,Pathology ,Swine ,Cancer Treatment ,Diagnostic Radiology ,0302 clinical medicine ,Pig Models ,Medicine and Health Sciences ,Angiosarcoma ,Diethylnitrosamine ,Tomography ,Hyaline ,Mammals ,Multidisciplinary ,Chromosome Biology ,Radiology and Imaging ,Sarcomas ,Liver Neoplasms ,Eukaryota ,Granulation tissue ,Animal Models ,Hepatic Angiosarcoma ,Chromosomal Aberrations ,medicine.anatomical_structure ,Oncology ,Experimental Organism Systems ,Connective Tissue ,030220 oncology & carcinogenesis ,Vertebrates ,Immunohistochemistry ,Medicine ,Anatomy ,Research Article ,Poor prognosis ,medicine.medical_specialty ,Histology ,Imaging Techniques ,Science ,Hemangiosarcoma ,Neuroimaging ,Research and Analysis Methods ,03 medical and health sciences ,Diagnostic Medicine ,Biomarkers, Tumor ,medicine ,Animals ,neoplasms ,business.industry ,Organisms ,Single shot ,Cancers and Neoplasms ,Biology and Life Sciences ,Cell Biology ,digestive system diseases ,Computed Axial Tomography ,Disease Models, Animal ,Biological Tissue ,030104 developmental biology ,Amniotes ,Animal Studies ,Granulation Tissue ,Tomography, X-Ray Computed ,business ,Neuroscience - Abstract
Background & aimPrimary hepatic angiosarcoma is a rare tumor with poor prognosis. The aim of this study was to generate a new angiosarcoma model to improve research on hepatic angiosarcoma.MethodsPigs sus scrofa were treated with different regimens of diethylnitrosamine (DENA). Tissues were analyzed by histology and immunohistochemistry. Serum parameters were determined. Angiosarcoma tissue was investigated for chromosomal aberrations by aCGH analysis.ResultsAnimals of almost all different treatment regimens developed a multitude of variable liver lesions. Different tumor types such as granulation tissue type, cellular-like, hyalinization necrosis-like, angiosarcoma-like, dysplastic nodule-like, hepatocellular-like, glandular structure-like, and leiomyoma-like lesions were observed. Weekly treatment with 15 mg/kg for up to 52 weeks or a single shot of 200 mg/kg DENA led to the development of hepatic angiosarcomas. aCGH analysis of angiosarcoma tissue revealed increased alterations in tumors compared to non-tumorous tissue. Most of the chromosomal alterations were found on chromosomes 6, 7, 12, and 14.ConclusionIn this preliminary study treatment of sus scrofa with weekly injections of 15 mg/kg DENA results in a new model for primary hepatic angiosarcoma. This model may help to shed light on the pathomechanisms of primary hepatic angiosarcoma and might therefore open new treatment options.
- Published
- 2019
31. Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report
- Author
-
Emily A. Rosen, Edwin Choy, Mounica Vallurupalli, David J. Kuter, and Jochen K. Lennerz
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Recombinant Fusion Proteins ,Hemangiosarcoma ,Receptors, Fc ,hepatic angiosarcoma ,03 medical and health sciences ,DIC ,0302 clinical medicine ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Clinical Case Report ,anticoagulation ,neoplasms ,Disseminated intravascular coagulation ,business.industry ,Liver Neoplasms ,Anticoagulants ,General Medicine ,Hepatic Angiosarcoma ,Disseminated Intravascular Coagulation ,Middle Aged ,medicine.disease ,digestive system diseases ,Antifibrinolytic Agents ,Endothelial stem cell ,Thrombopoietin ,030220 oncology & carcinogenesis ,business ,Gastrointestinal Hemorrhage ,030215 immunology ,circulatory and respiratory physiology ,Research Article - Abstract
Rationale: Hepatic angiosarcoma is a rare endothelial cell tumor that may lead to concurrent consumptive coagulopathies including disseminated intravascular coagulation (DIC). This report details a multifaceted approach to managing DIC in a patient with advanced-stage hepatic angiosarcoma, which continued to progress after a brief response to taxane-based chemotherapy. Patient concerns: A 55-year-old man with a recent history of hemorrhoids and hemarthroses presented with acute rectal bleeding. He was found to have concurrent hepatomegaly, abnormal liver function tests, anemia, thrombocytopenia, and coagulopathy. Diagnoses: DIC in the setting of hepatic angiosarcoma. Interventions: The patient's acute bleeding in the setting of DIC was controlled with a combination of antifibrinolytic agents to prevent clot breakdown, heparin products to prevent deposition of new clot, and romiplostim to increase platelet production. His angiosarcoma was treated with various combinations of chemotherapy, including taxane-based chemotherapy, doxorubicin, and pazopanib. Outcomes: The patient's DIC and acute bleeding on initial presentation improved following treatment with unfractionated heparin and low-molecular weight heparin maintenance therapy. It is unclear if the chemotherapy to treat the hepatic angiosarcoma played a significant role in the improvement of DIC. Lessons: Laboratory measurement of prothrombin fragment 1.2, a byproduct of prothrombin conversion to thrombin, proved to be a useful way to monitor this patient's DIC over time.
- Published
- 2018
32. Surgical therapy of primary hepatic angiosarcoma
- Author
-
Verena Tripke, Tobias Huber, Maria Hoppe-Lotichius, Hauke Lang, Beate K. Straub, Jens Mittler, and Stefan Heinrich
- Subjects
Male ,medicine.medical_specialty ,Hepatic resection ,Hemangiosarcoma ,lcsh:Surgery ,Resection ,03 medical and health sciences ,Surgical therapy ,0302 clinical medicine ,Surgical oncology ,Pancreatic cancer ,medicine ,Humans ,Prospective Studies ,Aged ,Liver resection ,business.industry ,Liver Neoplasms ,General Medicine ,Hepatic Angiosarcoma ,lcsh:RD1-811 ,Middle Aged ,medicine.disease ,Surgery ,Rare tumor ,030220 oncology & carcinogenesis ,Liver malignancies ,030211 gastroenterology & hepatology ,Female ,Tumor removal ,business ,Follow-Up Studies ,Research Article - Abstract
Background Primary hepatic angiosarcoma (PHA) is a rare tumor entity. Radical surgical resection is currently considered the best treatment choice. The aim of this analysis is to report our experience with surgery for PHA. Methods All resections of PHA from 01/2002 until 06/2017 were identified from our prospective institutional database. All cases were re-confirmed by a second pathologist. We analyzed completeness of resection, overall (OS) and disease-free survival (DFS). Results Nine patients with PHA underwent hepatic resection. Median follow-up after surgery was 15.5 months (range: 3–144). At last follow-up 4/9 patients were alive, three of them without recurrence 15, 21 and 144 months after surgery. Five patients developed PHA recurrence. Four of these died 3 to 17 months after surgery. One patient with PHA recurrence is alive 15 months after surgery. Another patient without PHA recurrence died 59 months after surgery from pancreatic cancer. Median OS and DFS after resection was 18 months (range: 3–144 months) and 10 months (range: 2–144 months), respectively. After R-0 resection (n = 8), the median OS and DFS was 59 and 11 months. Conclusions Resection of PHA is the only approach to achieve complete tumor removal and offers a chance for long-term survival and should be evaluated in cases of PHA.
- Published
- 2018
33. Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
- Author
-
Shuichi Wada, Naoki Tanaka, Ayumi Sugiura, Eiji Tanaka, Takeji Umemura, Daisuke Kubota, Takefumi Kimura, and Fumika Fujii
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Biopsy ,Hemangiosarcoma ,Kasabach-Merritt Phenomenon ,Specialties of internal medicine ,Hemorrhage ,Kasabach-Merritt Syndrome ,030230 surgery ,DIC ,03 medical and health sciences ,0302 clinical medicine ,Fatal Outcome ,Angiosarcoma ,medicine ,Coagulopathy ,Humans ,Embolization ,Aged ,Ultrasonography ,Hepatology ,medicine.diagnostic_test ,Rupture, Spontaneous ,business.industry ,Liver Neoplasms ,Magnetic resonance imaging ,bleeding tendency ,General Medicine ,Hepatic Angiosarcoma ,Disseminated Intravascular Coagulation ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Liver ,RC581-951 ,030220 oncology & carcinogenesis ,Female ,Radiology ,Fresh frozen plasma ,business ,Tomography, X-Ray Computed ,Kasabach-Merritt phenomenon ,Liver Failure - Abstract
A 76-year-old woman was referred to our hospital due to massive gingival bleeding following teeth extraction. Laboratory findings suggested disseminated intravascular coagulopathy (DIC). Enhanced computed tomography and magnetic resonance imaging disclosed multiple hypervascular liver masses of 2-6 cm in diameter, the largest of which displaying an irregular enhancement pattern. We considered that her DIC was caused by the multiple liver masses and commenced repeated erythrocyte/fresh frozen plasma infusion and gabexate mesilate administration. However, the DIC proved uncontrollable and trans-arterial embolization could not be attempted. The patient eventually died 4 months after admission due to spontaneous hepatic tumor rupture and hepatic failure. Post-mortem hepatic tumor biopsy led to a final diagnosis of hepatic angiosarcoma with Kasabach-Merritt phenomenon (KMP). Among the 7 cases of hepatic angiosarcoma representing KMP found in the literature, mortality occurred within 4 months of the appearance of bleeding tendency primarily due to abdominal bleeding and hepatic failure. The possibility of hepatic angiosarcoma should be considered in patients with DIC and hypervascular liver tumors. Since treatment is uncertain and prognosis is poor, novel diagnostic and therapeutic advances are needed for angiosarcoma.
- Published
- 2018
34. Metachronous Hepatic Angiosarcoma Presenting as a Mimic of Recurrent Hepatocellular Carcinoma
- Author
-
Harry L. Morrison, Eric Lau, Michael Deftos, Bernette Tsai, and Albert Lin
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Hemangiosarcoma ,Bone Neoplasms ,030204 cardiovascular system & hematology ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Neoplasm Recurrence ,X ray computed ,Biopsy ,medicine ,Carcinoma ,Humans ,Chemoembolization, Therapeutic ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Gastroenterology ,Neoplasms, Second Primary ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Recurrent Hepatocellular Carcinoma ,Radiation therapy ,Scapula ,Oncology ,Liver ,030220 oncology & carcinogenesis ,Biopsy, Large-Core Needle ,Neoplasm Recurrence, Local ,business ,Tomography, X-Ray Computed ,Liver pathology - Published
- 2018
35. Imaging findings of primary hepatic angiosarcoma on gadoxetate disodium-enhanced liver MRI: comparison with hepatic haemangiomas of similar size
- Author
-
B. Kim, J.H. Byun, J.H. Lee, B.J. Park, H.-J. Kwon, S.J. Lee, H.J. Won, Y.M. Shin, and P.N. Kim
- Subjects
Gadolinium DTPA ,Male ,medicine.medical_specialty ,Hemangiosarcoma ,Contrast Media ,Liver mri ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Vascular invasion ,Lesion ,Gadoxetate Disodium ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,neoplasms ,Aged ,Aorta ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Magnetic resonance imaging ,General Medicine ,Hepatic Angiosarcoma ,Middle Aged ,Image Enhancement ,Magnetic Resonance Imaging ,digestive system diseases ,030211 gastroenterology & hepatology ,Female ,Radiology ,Signal intensity ,medicine.symptom ,business ,Hemangioma - Abstract
To describe imaging characteristics of primary hepatic angiosarcoma on gadoxetate disodium-enhanced dynamic magnetic resonance imaging (MRI) and to determine features that differentiate angiosarcomas from similar-sized haemangiomas.The study included 15 patients with hepatic angiosarcomas and 35 patients with size-matched hepatic haemangiomas who underwent gadoxetate disodium-enhanced liver MRI. The number, size, growth pattern, signal intensity (SI) characteristics, and SI changes on dynamic scans were evaluated and compared between the two entities.Overall, hepatic angiosarcomas significantly more often showed lesion multiplicity (86.7%), capsular retraction (40%), prominent intratumoural vessels (66.7%), vascular invasion (20%), heterogeneous SI on T2-weighted (100%) and hepatobiliary phase images (80%), and intralesional haemorrhage (60%, all p0.05). On dynamic scans, angiosarcomas demonstrated enhancing foci of irregular or rim-like nodular/linear or bizarre (86.7%) shapes, with centrifugal or bizarre patterns of progressive enhancement (53.3%). Enhancement of angiosarcomas was less than that of the blood pool on visual grading, but the enhancement curves followed that of the aorta. Regardless of size, angiosarcomas showed heterogeneous T2 SI, intratumoural haemorrhage, and heterogeneity during the hepatobiliary phase, whereas these findings were more common in haemangiomas6 cm in diameter.Gadoxetate disodium-enhanced dynamic liver MRI is capable of depicting vascular hallmarks of hepatic angiosarcomas. Heterogeneous SI on T2-weighted and hepatobiliary phase images, multiplicity, and an enhancement curve following that of the aorta are also distinctive features that differentiate angiosarcomas from haemangiomas.
- Published
- 2017
36. Clinical case series of pediatric hepatic angiosarcoma
- Author
-
Kalee L. Grassia, Ewa Bien, Denise M. Adams, Ionela Iacobas, Rebecka L. Meyers, Bhavna Padhye, Judith F. Margolin, and Caitlin M. Peterman
- Subjects
Male ,medicine.medical_specialty ,Hemangiosarcoma ,Hepatic hemangioendothelioma ,Hemangioendothelioma ,Hemangioma ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Angiosarcoma ,neoplasms ,business.industry ,Liver Neoplasms ,Hematology ,Hepatic Angiosarcoma ,Benign lesion ,medicine.disease ,Prognosis ,digestive system diseases ,Liver Transplantation ,body regions ,Oncology ,030220 oncology & carcinogenesis ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Vascular tumor ,030211 gastroenterology & hepatology ,Female ,Radiology ,Clinical case ,business - Abstract
Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a "vascular tumor." Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low-grade form of angiosarcoma rather than a benign lesion.
- Published
- 2017
37. A primary hepatic angiosarcoma mimicking intrahepatic cholangiocarcinoma on conventional ultrasound and contrast-enhanced ultrasound: A case report and review of literatures
- Author
-
Hui-Xiong Xu, Mei Yu, Le-Hang Guo, Li-Ping Sun, and Chong-Ke Zhao
- Subjects
Adult ,Male ,Poor prognosis ,medicine.medical_specialty ,Physiology ,Hemangiosarcoma ,Contrast Media ,Malignancy ,Conventional ultrasound ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Medicine ,Humans ,Contrast-enhanced Magnetic Resonance Imaging ,Intrahepatic Cholangiocarcinoma ,Ultrasonography ,business.industry ,Ultrasound ,Liver Neoplasms ,Hematology ,Hepatic Angiosarcoma ,medicine.disease ,030220 oncology & carcinogenesis ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Contrast-enhanced ultrasound - Abstract
Primary hepatic angiosarcoma (PHA) is a rare malignancy with a badly poor prognosis. The extremely low morbidity and untypical clinical manifestations conduce to a missed diagnosis. The present study reported a case of an adult male patient who was pathologically confirmed to be PHA, which mimicked intrahepatic cholangiocarcinoma on conventional ultrasound and contrast-enhanced ultrasound. Findings on various imaging examinations were carefully evaluated and the associated literatures were also reviewed.
- Published
- 2016
38. CT and MRI studies of hepatic angiosarcoma
- Author
-
Jia Li, S.-G. Zhou, Y.-Q. Huang, Jian Zhang, R.-N. Wang, X. Yu, L.-L. Yi, and Jian Wang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Hemangiosarcoma ,Contrast Media ,Mri studies ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Angiosarcoma ,Aged ,Prothrombin time ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Magnetic resonance imaging ,General Medicine ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Hyperintensity ,030220 oncology & carcinogenesis ,Female ,Radiology ,Tomography ,Tomography, X-Ray Computed ,business ,Calcification - Abstract
AIM To analyse the computed tomography (CT) and magnetic resonance imaging (MRI) manifestations of hepatic angiosarcoma. MATERIALS AND METHODS Nineteen patients with hepatic angiosarcoma underwent preoperative abdominal unenhanced and contrast-enhanced CT (11 cases) or (eight cases) MRI. RESULTS The results of a coagulation examination showed varying degrees of abnormalities in 12 (63.16%) cases (most were prolonged prothrombin time and an increased proportion of prothrombin time), which were the most common abnormalities on the laboratory tests. Unenhanced CT of the lesions showed homogeneous or heterogeneous hypointense with hyperintense haemorrhagic lesions, contrast-enhanced CT was performed for six cases (6/11, 54.5%) with centripetal heterogeneous filling. All lesions showed heterogeneous intensity at MRI, including heterogeneous hypointense T1WI and homogeneous or heterogeneous hyperintense T2WI. Haemorrhage lesions showed higher hyperintensity with spot or patchy signals. Centripetal enhancement was found in six cases using contrast-enhanced imaging. Flaky patches of contrast enhancement were seen in the lesions. CONCLUSION The CT and MRI features of most of the hepatic angiosarcomas in the present study were relatively characteristic: the border of the mass was indistinct, the density was heterogeneous, and haemorrhage was frequently seen, with secondary calcification in a few cases, whereas enhanced imaging showed typical centripetal heterogeneous enhancement. In addition, highly malignant angiosarcoma could not be enhanced.
- Published
- 2019
39. Hepatic angiosarcoma: A suggestive pattern of enhancement on dynamic MR imaging
- Author
-
A. Rullier, Hervé Trillaud, Jean-Frédéric Blanc, Christophe Cassinotto, and Arnaud Hocquelet
- Subjects
medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Dynamic mr ,Vascular tumors ,Sarcoma ,General Medicine ,Hepatic Angiosarcoma ,Image enhancement ,medicine.disease ,Mr imaging ,Vascular Tumors ,Liver neoplasms ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,MR imaging - Published
- 2015
40. Hepatic Hemangiosarcoma
- Author
-
Juan-Carlos Garcia Valdecasas, François-René Pruvot, Robert J. Porte, Andrew K. Burroughs, Darius F. Mirza, Jan Lerut, Christian Seiler, Giuseppe Orlando, Ivo Graziadei, Goran Soderdahl, René Adam, Michele Colledan, Andreas Paul, Vincent Karam, Faculteit Medische Wetenschappen/UMCG, Groningen Institute for Organ Transplantation (GIOT), Orlando, G, Adam, R, Mirza, D, Soderdahl, G, Porte, R, Paul, A, Burroughs, A, Seiler, C, Colledan, M, Graziadei, I, Valdecasas, J, Pruvot, F, Karam, V, and Lerut, J
- Subjects
Male ,ANGIOSARCOMA ,SURGERY ,Biopsy ,medicine.medical_treatment ,Medizin ,Vascular tumors ,Liver transplantation ,Hemangioendothelioma ,Hepatic angiosarcoma ,Recurrence ,Registries ,Epithelioid hemangioendothelioma ,Child ,SARCOMA ,OUTCOMES ,HEMANGIOMA ,Liver Neoplasms ,Middle Aged ,Europe ,Treatment Outcome ,Child, Preschool ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Hemangiosarcoma ,Vascular tumor ,medicine ,MANAGEMENT ,Humans ,Contraindication ,Retrospective Studies ,MALIGNANCY ,Transplantation ,business.industry ,CLINICAL-FEATURES ,Infant ,LONG-TERM SURVIVAL ,Retrospective cohort study ,medicine.disease ,HEMANGIOENDOTHELIOMA ,Surgery ,Differential diagnosis ,business ,Liver Failure - Abstract
Background. Liver transplantation (LT) is performed for hemangiosarcoma (HAS) despite disappointing results. Methods. Retrospective study of 14 males and 8 females reported to the European Liver Transplant Registry. In view of the difficult differential diagnosis between HAS and hemangioendothelioma (HE), the study was deliberately restricted to the period 1986 to 2004 to allow comparison of clinical and biochemical behavior of HAS and HE liver recipients transplanted during the same time period. Results. Clinical signs, symptoms, and biochemical parameters differed significantly. Pre-LT diagnosis of HAS was made in only 5 of 16 (31%) biopsied patients. HE (7 patients) and hepatocellular cancer (2 patients) were confounding diagnoses leading to LT. Extrahepatic disease was present at time of LT in 4 (19%) patients. Giant invalidating tumor (5 HAS, 1 with Budd-Chiari syndrome [BCS], and 10 supposed epithelioid hemangioendothelioma, 1 with BCS), acute BCS of unknown origin (2 patients), chronic liver failure (4 patients), and solitary hepatocellular cancer (1 patient) were the main indications for LT. Overall survival was 7.2±2.6 months; no patient survived after 23 months. Recurrence was diagnosed after 5.0±2.6 months. Seventeen (77.2%) patients died of tumor recurrence, and the remaining 5 patients died of early infections. Conclusions. HAS is an absolute contraindication to LT due to the poor outcome. When dealing with the difficult differential diagnosis between HAS and HE, futile LT can be avoided by taking into consideration their distinct clinical and biochemical behaviors as well as a 6-month wait-list observation period. This time period enables the evaluation of HAS disease progression without compromising prognosis of HE patients, thereby allowing to avoid organ wastage. © 2013 Lippincott Williams & Wilkins.
- Published
- 2013
41. The Natural History of a Hepatic Angiosarcoma that was Difficult to Differentiate from Cavernous Hemangioma
- Author
-
Masaya Ohana, Takanori Taniguchi, Akihiro Okano, Yuuki Masano, Fusako Kusumi, Hiroki Sonoyama, and Motoshige Nabeshima
- Subjects
Male ,Abdominal pain ,medicine.medical_specialty ,business.industry ,Arterial Embolization ,Hemangiosarcoma ,Liver Neoplasms ,General Medicine ,Hepatic Angiosarcoma ,medicine.disease ,Diagnosis, Differential ,Natural history ,Hemangioma ,Fatal Outcome ,Hemangioma, Cavernous ,Internal Medicine ,Humans ,Medicine ,Angiosarcoma ,Radiology ,Differential diagnosis ,medicine.symptom ,business ,Aged - Abstract
A 69-year old man came to our hospital complaining of abdominal pain. Contrast-enhanced computed tomography (CT) showed a 65-mm ruptured mass in Couinaud segment 5 of the liver. The mass was treated with emergent transcatheter arterial embolization (TAE), followed by partial hepatectomy. Microscopically, the mass was determined to be an angiosarcoma. Six months previously, enhanced CT had shown a 15-mm mass diagnosed as a cavernous hemangioma in the same region of the liver. Even when the enhancement pattern of a small hepatic mass resembles that of hemangioma, the mass should be reassessed within several months to exclude a diagnosis of hepatic angiosarcoma.
- Published
- 2012
42. Hepatic Angiosarcoma with Dyskeratosis Congenita
- Author
-
Yoichi Nakazato, Yuichi Yamazaki, Norio Horiguchi, Motoyasu Kusano, Satoshi Hagiwara, Tatsuya Ohyama, Satoru Kakizaki, Keisuke Iizuka, Masanobu Yamada, Nobuyuki Shibusawa, and Ken Sato
- Subjects
musculoskeletal diseases ,CD31 ,Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Pathology ,medicine.medical_specialty ,Hemangiosarcoma ,Malignancy ,Dyskeratosis Congenita ,Fatal Outcome ,hemic and lymphatic diseases ,Oral and maxillofacial pathology ,Internal Medicine ,medicine ,Humans ,Angiosarcoma ,skin and connective tissue diseases ,Leukoplakia ,Factor VIII ,business.industry ,Liver Neoplasms ,General Medicine ,Hepatic Angiosarcoma ,medicine.disease ,Platelet Endothelial Cell Adhesion Molecule-1 ,Leukoplakia, Oral ,business ,Dyskeratosis congenita - Abstract
Nail dystrophy, oral leukoplakia and abnormal skin pigmentation are the defining features of dyskeratosis congenita. Dyskeratosis congenita is a disorder of poor telomere maintenance and is known to increase the risk of developing multiple types of malignancy. However, there are few reports of liver tumors arising in dyskeratosis congenita patients. We herein report the second case of hepatic angiosarcoma arising from dyskeratosis congenita: a 23-year-old man was introduced to our hospital due to the detection of multiple tumors in the liver. A histological analysis showed angiosarcoma that stained positive for antibodies to both CD31 and blood coagulation factor VIII.
- Published
- 2015
43. Primary hepatic angiosarcoma
- Author
-
Francesco Ardito, Alessandro Coppola, Giuseppe Bianco, Felice Giuliante, and Ivo Giovannini
- Subjects
medicine.medical_specialty ,Settore MED/18 - CHIRURGIA GENERALE ,medicine.medical_treatment ,Hemangiosarcoma ,MEDLINE ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,X ray computed ,medicine ,Hepatectomy ,Humans ,Primary hepatic angiosarcoma ,Aged ,Primary (chemistry) ,business.industry ,Liver Neoplasms ,General Medicine ,Hepatic Angiosarcoma ,030220 oncology & carcinogenesis ,liver resection ,030211 gastroenterology & hepatology ,Surgery ,Female ,Radiology ,business ,Tomography, X-Ray Computed - Published
- 2015
44. Spontaneous rupture of a necrotic hepatic angiosarcoma: findings on dual-phase computed tomography and angiography
- Author
-
Naoto Ohmura, Hiroaki Kurokawa, Minoru Maehara, Kenji Koda, Hidetaro Yokoyama, Koshi Ikeda, and Satoshi Sawada
- Subjects
Male ,Radiography, Abdominal ,medicine.medical_specialty ,Necrosis ,medicine.medical_treatment ,Hemangiosarcoma ,Computed tomography ,Hemangioma ,Fatal Outcome ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Angiosarcoma ,Radiation ,Rupture, Spontaneous ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Angiography ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,eye diseases ,Radiation therapy ,Oncology ,sense organs ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
We present dual-phase computed tomographic (CT) and angiographic findings of a ruptured hepatic angiosarcoma. These tumors can be divided into two types: those with and those without gross central necrosis with hemorrhage. In our case, the tumor had gross central necrosis, and CT and angiographic findings showed a small number of areas with a centripetal enhancement pattern and the rest of the tumor with avascular areas. We found that dual-phase CT and angiographic findings are able to distinguish angiosarcoma, which mimics a hemangioma, as these lesions show avascular areas that reflect a mass with gross central necrosis.
- Published
- 2006
45. A case of hepatic angiosarcoma supplied by both hepatic artery and portal vein
- Author
-
Hoshi, Namiko, Mukai, Shinji, Oishi, Miyuki, Takano, Makoto, Shinzawa, Jotaro, Watanabe, Shigeru, Yamazaki, Shigeru, Sakuma, Hideo, Ohira, Hiromasa, Obara, Katsutoshi, Kasukawa, Reiji, and Sato, Yukio
- Subjects
Hemangiosarcoma ,CTA ,Portal Vein ,Liver ,Humans ,Middle Aged ,Male ,Portal venous supply ,Hepatic Artery ,Liver Neoplasms ,digestive system diseases ,Hepatic angiosarcoma ,493.475 ,CTAP ,Tomography, X-Ray Computed ,neoplasms ,Angiography - Abstract
Liver neoplasms, whether they are benign or malignant, are usually fed by the hepatic artery. We experienced a case of hepatic angiosarcoma supplied by both hepatic artery and portal vein. Since there are currently no specific laboratory tests to diagnose hepatic angiosarcoma, it is important to detect suspect cases from imaging features. This unique hemodynamic property was detected on computed tomography (CT) during hepatic arteriography and CT during hepatic arterioportography. If any imaging examinations indicate the liver tumor to be fed by the portal vein, hepatic angiosarcoma should be suspected.
- Published
- 2006
46. A CASE OF HEPATIC ANGIOSARCOMA SUPPLIED BY BOTH HEPATIC ARTERY AND PORTAL VEIN
- Author
-
Katsutoshi Obara, Makoto Takano, Miyuki Oishi, Shigeru Watanabe, Yukio Sato, Hideo Sakuma, Hiromasa Ohira, Shinji Mukai, Shigeru Yamazaki, Reiji Kasukawa, Jotaro Shinzawa, and Namiko Hoshi
- Subjects
Male ,medicine.medical_specialty ,Liver tumor ,Portal venous pressure ,Hemangiosarcoma ,Portal vein ,Hemodynamics ,Computed tomography ,Hepatic Artery ,medicine ,Humans ,neoplasms ,medicine.diagnostic_test ,Portal Vein ,business.industry ,Liver Neoplasms ,Angiography ,General Medicine ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,Liver ,Radiology ,Tomography, X-Ray Computed ,business ,Artery - Abstract
Liver neoplasms, whether they are benign or malignant, are usually fed by the hepatic artery. We experienced a case of hepatic angiosarcoma supplied by both hepatic artery and portal vein. Since there are currently no specific laboratory tests to diagnose hepatic angiosarcoma, it is important to detect suspect cases from imaging features. This unique hemodynamic property was detected on computed tomography (CT) during hepatic arteriography and CT during hepatic arterioporto graphy. If any imaging examinations indicate the liver tumor to be fed by the portal vein, hepatic angiosarcoma should be suspected.
- Published
- 2006
47. Primary hepatic angiosarcoma: A report of two cases and literature review
- Author
-
Hong-Jie Hu, Guan-Yu Wang, Zhi-Nong Jiang, Ren-Biao Chen, Chao-Jie Huang, Yi-ping Zhu, Yan-Min Chen, Erik Matro, and Yi-Ping Mou
- Subjects
Male ,medicine.medical_specialty ,Poor prognosis ,Time Factors ,medicine.medical_treatment ,Biopsy ,Hemangiosarcoma ,Case Report ,Malignancy ,Fatal Outcome ,medicine ,Biomarkers, Tumor ,Hepatectomy ,Humans ,Chemoembolization, Therapeutic ,Postoperative chemotherapy ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Gastroenterology ,General Medicine ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Postoperative survival ,Immunohistochemistry ,Magnetic Resonance Imaging ,Surgery ,Treatment Outcome ,Chemotherapy, Adjuvant ,Female ,business ,Tomography, X-Ray Computed - Abstract
Primary hepatic angiosarcoma (PHA) is a rare malignancy that carries a poor prognosis. Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and outcomes of the two patients were collected and analyzed. Both patients underwent hepatectomy and had a postoperative survival time of 8 and 16 mo, respectively. A search of PubMed yielded eight references reporting 35 cases of PHA published between 2004 and 2013. On the basis of the presented cases and review of the literature, we endorse complete surgical resection as the mainstay definitive treatment of PHA, with adjuvant postoperative chemotherapy potentially improving survival. Palliative chemotherapy is an option in advanced hepatic angiosarcoma.
- Published
- 2014
48. Primary Hepatic Angiosarcoma: Findings at CT and MR Imaging
- Author
-
Lawrence J. Burgart, Joel G. Fletcher, Mark S. Kuo, C. Daniel Johnson, Kenji Notohara, and Takashi Koyama
- Subjects
Adult ,Male ,medicine.medical_specialty ,Hemangiosarcoma ,Lesion Number ,Lesion ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Angiosarcoma ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Magnetic resonance imaging ,Hepatic Angiosarcoma ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Mr imaging ,Female ,Tomography ,Radiology ,Sarcoma ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
To evaluate and describe cross-sectional imaging findings in patients with pathologically confirmed primary hepatic angiosarcoma.Findings from imaging examinations in 13 patients with pathologically confirmed primary hepatic angiosarcoma were retrospectively reviewed (computed tomographic [CT] images obtained in 10 patients and magnetic resonance [MR] images obtained in five patients were available for review). Two gastrointestinal radiologists evaluated lesion number, size, attenuation and signal intensity characteristics, and the pattern and degree of contrast material enhancement. Medical records were reviewed for clinical features associated with angiosarcoma.Angiosarcoma appeared as multiple nodules (n = 6), as dominant masses (n = 6), or as a diffusely infiltrating lesion (n = 1). Multiple nodules were hypoattenuating at unenhanced and contrast material--enhanced CT (six of six patients). When dominant masses were encountered at MR imaging, T2-weighted MR imaging demonstrated heterogeneous internal architecture (four of four patients) similar to that of hepatocellular carcinoma. Multiphase contrast-enhanced CT and MR images showed dominant masses to have heterogeneous and progressive enhancement (three of three patients). Clinical features associated with angiosarcoma included splenic metastases (six of 13 patients), thrombocytopenia (seven of 13 patients), disseminated intravascular coagulation (four of 13 patients), and hemolytic anemia (three of 13 patients).Primary hepatic angiosarcoma exhibits a spectrum of appearances that reflect its varied pathologic features.
- Published
- 2002
49. Primary hepatic angiosarcoma
- Author
-
R.A.K. Singh, Arvind Ahuja, Poras Chaudhary, and U. Bhadana
- Subjects
CD31 ,Abdominal pain ,Pathology ,medicine.medical_specialty ,Chemotherapy ,Delayed Diagnosis ,business.industry ,medicine.medical_treatment ,Hemangiosarcoma ,Liver Neoplasms ,General Medicine ,Hepatic Angiosarcoma ,medicine.disease ,Abdominal mass ,Oncology ,Practice Guidelines as Topic ,medicine ,Etiology ,Humans ,Surgery ,medicine.symptom ,business ,Pathological - Abstract
Primary hepatic angiosarcoma is a rare, aggressive tumor; composed of spindle or pleomorphic cells that line, or grow into, the lumina of pre-existing vascular spaces like sinusoids and terminal hepatic venules; with only about 200 cases diagnosed annually worldwide but it is the most common primary malignant mesenchymal tumor of the liver in adults and accounts for 2% of all primary hepatic malignancies. HAS occurs in association with known chemical carcinogens, but 75% of the tumors have no known etiology. Patients present with vague symptoms like abdominal pain, weight loss, fatigue or an abdominal mass. Hepatic angiosarcoma is usually multicentric and involves both lobes, entire liver may also found to be involved. CD31 is the most reliable marker. These tumors lack specific features on imaging, so, pathological diagnosis is necessary. There are no established treatment guidelines because of low frequency and aggressive nature of tumor, chemotherapy is only palliative, liver resection is indicated for solitary mass and liver transplant is contraindicated. The aim of this article is to comprehensively review all the available literature and to present detailed information and an update on primary hepatic angiosarcoma.
- Published
- 2014
50. Metastatic Angiosarcoma of the Liver Preoperatively Presenting as Giant Hemangioma
- Author
-
Timo Kirschstein, Waldemar Uhl, Arthur Zimmermann, Daniel Aeberli, and Markus W. Büchler
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Hemangiosarcoma ,Diagnosis, Differential ,X ray computed ,medicine ,Humans ,neoplasms ,medicine.diagnostic_test ,Metastatic angiosarcoma ,business.industry ,organic chemicals ,Liver Neoplasms ,technology, industry, and agriculture ,Gastroenterology ,Magnetic resonance imaging ,Giant Hemangioma ,Hepatic Angiosarcoma ,Middle Aged ,Magnetic Resonance Imaging ,Thrombocytopenia ,digestive system diseases ,Radiology ,Differential diagnosis ,Hemangioma ,Tomography, X-Ray Computed ,business - Abstract
Background: Hepatic angiosarcomas are rare tumors most often associated with exposure to vinyl chloride or other carcinogens. Only a few cases have been published without such a history. Case Report: We report the case of a 73-year-old woman who was admitted to our medical department with unclear upper abdominal pain, thrombocytopenia and anemia. Both computed tomography and magnet resonance imaging revealed a giant hemangioma in the right liver with multiple small hemangiomas. To cure the problem of thrombocytopenia due to sequestration of blood cells in the hemangioma, we decided to resect the large tumor. Intraoperatively, however, the diagnosis of angiosarcoma with multiple metastases was made. The patient died 6 weeks after surgery. Conclusion: Problems in diagnosing angiosarcoma include the brief duration of antecedent symptoms, difficulties in radiological diagnosis, and patients without a history of professional exposure to carcinogens.
- Published
- 2000
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.