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Start Over Author "Neef, Markus" Topic liver failure
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1. Acenocoumarol is not a safe alternative for anticoagulation in phenprocoumon-induced hepatic failure. Report of two cases.

Author

Neef M, Kerekes Z, Fischer HP, Sauerbruch T, and Spengler U

Subjects
Female, Humans, International Normalized Ratio, Liver drug effects, Liver Failure therapy, Liver Function Tests, Liver Transplantation, Male, Middle Aged, Acenocoumarol adverse effects, Anticoagulants adverse effects, Liver pathology, Liver Failure chemically induced, Phenprocoumon adverse effects
Abstract

Acenocoumarol has been proposed repeatedly as a safe alternative drug regimen for oral anticoagulation in patients who have suffered phenprocoumon-induced fulminant hepatic failure. The current report describes 2 patients with phenprocoumon-induced hepatic failure, necessitating liver transplantation in 1 case, who showed recurrence of liver damage when oral anticoagulation with acenocoumarol was attempted. Thus, acenocoumarol may not be a safe therapeutic alternative for patients who survived severe phenprocoumon-induced hepatotoxicity., (Copyright 2003 S. Karger AG, Basel)

Published
2003
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