1. Factors associated with the impossibility to obtain reliable liver stiffness measurements by means of Acoustic Radiation Force Impulse (ARFI) elastography--analysis of a cohort of 1,031 subjects.
- Author
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Bota S, Sporea I, Sirli R, Popescu A, Danila M, Jurchis A, and Gradinaru-Tascau O
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Cohort Studies, Elastic Modulus, Female, Humans, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Sex Distribution, Young Adult, Diagnostic Errors statistics & numerical data, Elasticity Imaging Techniques statistics & numerical data, Liver diagnostic imaging, Liver physiopathology, Liver Diseases diagnostic imaging, Liver Diseases physiopathology
- Abstract
Introduction: Acoustic Radiation Force Impulse (ARFI) elastography is a non-invasive technique for liver fibrosis assessment., Aim: To assess the feasibility of ARFI elastography in a large cohort of subjects and to identify factors associated with impossibility to obtain reliable liver stiffness (LS) measurements by means of this technique., Methods: Our retrospective study included 1031 adult subjects with or without chronic liver disease. In each subject LS was assessed by means of ARFI elastography. Failure of ARFI measurements was defined if no valid measurement was obtained after at least 10 shots and unreliable in the following situations: fewer than 10 valid shots; or median value of 10 valid measurements with a success rate (SR)<60% and/or an interquartile range interval (IQR) ≥ 30%., Results: Failure of LS measurements by means of ARFI was observed in 4 subjects (0.3%), unreliable measurements in 66 subjects (6.4%), so reliable measurements were obtained in 961 subjects (93.3%). In univariant analysis, the following risk factors were associated with failed and unreliable measurements: age over 58 years (OR=0.49; 95% CI 0.30-0.80, p=0.005), male gender (OR=0.58; 95% CI 0.34-0.94, p=0.04), BMI>27.7 kg/m(2) (OR=0.23, 95% CI 0.13-0.41, p<0.0001). In multivariate analysis all the factors mentioned above were independently associated with the risk of failed and unreliable measurements., Conclusions: Reliable LS measurements by means of ARFI elastography were obtained in 93.3% of cases. Older age, higher BMI and male gender were associated with the risk of failed and unreliable measurements, but their influence is limited as compared with Transient Elastography., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
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