1. Stereotactic body radiotherapy used as a bridge to liver transplant in patients with hepatocellular carcinoma and Child-Pugh score =8 cirrhosis.
- Author
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Gresswell, Steven, Tobillo, Rachel, Hasan, Shaakir, Uemura, Tadahiro, Machado, Lorenzo, Ngoc Thai, and Kirichenko, Alexander
- Subjects
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LIVER cancer , *STEREOTACTIC radiotherapy , *CIRRHOSIS of the liver , *LIVER diseases , *LIVER cells - Abstract
Introduction: To report on SBRT as a bridge to OLT for patients with HCC and Child-Pugh =8 cirrhosis. Methods: Retrospective review of 15 patients, treated from 2010-2017. Three patients excluded secondary to delisting from prohibitive substance. Twelve patients (17 lesions) included for final analysis. Hepatic SPECT functional treatment planning utilized. Results: The median age of 60 years with a median CP 9 and MELD 14. The median SBRT dose was 40 Gy in 5 fractions, and median tumor size was 2.3cm (1.2-5.3cm). Median follow-up and survival was 40-months and 46-months, respectively. One patient succumbed to renal/hepatic failure before OLT. Radiographic response was 80%. pCR at explant was 46%. No grade = 3 acute toxicities. Median time to progression of CP = 2 was 9.7-months and MELD progression was not met before OLT. Conclusion: SBRT with functional treatment planning can be used safely as a bridge to OLT in select patients with CP =8 cirrhosis. [ABSTRACT FROM AUTHOR]
- Published
- 2018