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6 results on '"Myerson RM"'

2. A method for serum octanoate in hepatic cirrhosis and hepatic encephalopathy.

Author

Rabinowitz JL, Staeffen J, Aumonier P, Ballan P, Ferrer J, Terme R, Series C, and Myerson RM

Subjects
Humans, Liver Cirrhosis, Alcoholic pathology, Mass Spectrometry methods, Caprylates blood, Liver pathology, Liver Cirrhosis, Alcoholic blood
Abstract

We describe a new, more efficient, and more reproducible method for determination of octanoate in serum. This method involves ethanol extraction, followed immediately by alkali addition before concentration of the extract. The concentrate is made acidic only before it is to be steam distilled (in a special all-glass apparatus with an alkali trap). The material is acidified again just before separation by gas-liquid chromatography. The yield is 89-107%. When assayed by mass spectrometry, only octanoate was found in the fraction from chromatography. Previous methods yielded only 30-55% of the expected octanoate value and the recovered materials showed impurities by mass spectrometry. Octanoate concentrations were determined in the serum of 24 fasting controls and that of 85 fasting cirrhotic patients, of whom 50 had encephalopathy. Concentrations in arterial and venous blood were significantly higher in cirrhotic patients in coma than in those not in coma, and arterial concentrations were statistically higher than venous concentrations in the cirrhotic patients.

Published
1977

5. Metabolic aspects of alcohol and their biological significance.

Author

Myerson RM

Subjects
Acetaldehyde metabolism, Alcohol Oxidoreductases metabolism, Animals, Bone and Bones metabolism, Cardiomyopathies chemically induced, Catalase metabolism, Chemical and Drug Induced Liver Injury etiology, Endocrine System Diseases chemically induced, Ethanol adverse effects, Gastrointestinal Diseases chemically induced, Hematologic Diseases chemically induced, Humans, Kidney metabolism, Lipid Metabolism, Muscular Diseases chemically induced, Peripheral Nervous System Diseases chemically induced, Psychoses, Alcoholic etiology, Substance Withdrawal Syndrome, Alcoholism metabolism, Ethanol metabolism, Liver metabolism
Published
1973
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6. A method for serum octanoate in hepatic cirrhosis and hepatic encephalopathy

Author

Ballan P, Staeffen J, Myerson Rm, Aumonier P, Ferrer J, Terme R, Series C, and Joseph L. Rabinowitz

Subjects
Coma, Ethanol, Cirrhosis, Chromatography, Biochemistry (medical), Clinical Biochemistry, Encephalopathy, Extraction (chemistry), Venous blood, Mass spectrometry, medicine.disease, Mass Spectrometry, chemistry.chemical_compound, Liver, chemistry, Biochemistry, Liver Cirrhosis, Alcoholic, medicine, Humans, Caprylates, medicine.symptom, Hepatic encephalopathy
Abstract

We describe a new, more efficient, and more reproducible method for determination of octanoate in serum. This method involves ethanol extraction, followed immediately by alkali addition before concentration of the extract. The concentrate is made acidic only before it is to be steam distilled (in a special all-glass apparatus with an alkali trap). The material is acidified again just before separation by gas-liquid chromatography. The yield is 89-107%. When assayed by mass spectrometry, only octanoate was found in the fraction from chromatography. Previous methods yielded only 30-55% of the expected octanoate value and the recovered materials showed impurities by mass spectrometry. Octanoate concentrations were determined in the serum of 24 fasting controls and that of 85 fasting cirrhotic patients, of whom 50 had encephalopathy. Concentrations in arterial and venous blood were significantly higher in cirrhotic patients in coma than in those not in coma, and arterial concentrations were statistically higher than venous concentrations in the cirrhotic patients.

Published
1977
Full Text
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