1. Signalling pathways and transcriptional regulators orchestrating liver development and cancer
- Author
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Tabea L. Stephan, Sibyl Drissler, Pamela A. Hoodless, Stephanie A. Campbell, Jeremy Lotto, and Rebecca Cullum
- Subjects
Cell ,Biology ,Regenerative medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Induced pluripotent stem cell ,Molecular Biology ,Transcription factor ,030304 developmental biology ,0303 health sciences ,Tissue Engineering ,Cell growth ,Liver cell ,Liver Neoplasms ,Cancer ,Cell Differentiation ,Epithelial Cells ,medicine.disease ,Liver Regeneration ,3. Good health ,Cell biology ,medicine.anatomical_structure ,Liver ,Hepatocytes ,030211 gastroenterology & hepatology ,Liver cancer ,Signal Transduction ,Transcription Factors ,Developmental Biology - Abstract
Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell maturity can be perturbed by genetic and environmental factors that disrupt hepatic identity and function. Developmental signals and fetal genetic programmes are often dysregulated or reactivated, leading to dedifferentiation and disease. Here, we highlight signalling pathways and transcriptional regulators that drive liver cell development and primary liver cancers. We also discuss emerging models derived from pluripotent stem cells, 3D organoids and bioengineering for improved studies of signalling pathways in liver cancer and regenerative medicine.
- Published
- 2021