1. Liver fibrosis and liver stiffness in patients with obesity and type 1 diabetes.
- Author
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Al-Ozairi E, Irshad M, AlKandari J, Mashankar A, Alroudhan D, and le Roux CW
- Subjects
- Humans, Male, Female, Cross-Sectional Studies, Middle Aged, Adult, Prospective Studies, Body Mass Index, Magnetic Resonance Imaging, Fatty Liver complications, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 physiopathology, Obesity complications, Liver Cirrhosis complications, Elasticity Imaging Techniques, Liver diagnostic imaging, Liver pathology, Diabetes Mellitus, Type 2 complications
- Abstract
Aim: To compare hepatic stiffness and fat fraction in patients with obesity and type 1 diabetes (T1D) with type 2 diabetes (T2D) with a similar body mass index (BMI)., Methods: In this prospective cross-sectional study, 90 participants with T1D (BMI 30.5 ± 4.5 kg/m
2 ; diabetes duration 20.5 ± 9.8 years; HbA1c 8.2% ± 1.4%) and 69 with T2D (BMI: 30.8 ± 4.6 kg/m2 ; diabetes duration: 11.7 ± 7.8 years; HbA1c: 7.3% ± 1.4%) were included. Liver fat fraction and stiffness were examined by magnetic resonance imaging and elastography, respectively. Logistic regressions were used to evaluate associations with biomedical variables., Results: The mean liver stiffness score in patients with obesity and T1D was 2.2 ± 0.5 kPa, while in T2D it was 2.6 ± 0.8 kPa (P < .001). The liver fat fraction in patients with obesity and T1D was 3.7% ± 6.3%, and in T2D it was 10.6% ± 7.9% (P < .001). Metabolic dysfunction-associated steatotic liver disease (MASLD) was present in 13.3% of patients with T1D and in 69.6% of patients with T2D, whereas fibrosis was suggested in 7.8% of patients with T1D and in 27.5% of patients with T2D. Liver stiffness was four times higher in patients with T2D compared with those with T1D (odds ratio = 5.4, 95% confidence interval: 2.1-13.6, P < .001). Aspartate transaminase (AST), alanine transaminase, gamma-glutamyl transferase (GGT), triglycerides and the android-to-gynoid ratio were associated with elevated fat fraction in both cohorts. AST and GGT were associated with elevated liver stiffness in both cohorts., Conclusions: Patients with obesity and T1D had lower liver fat and liver stiffness compared with those patients with T2D, despite similar levels of BMI, a longer duration of diabetes and worse glycaemic control., (© 2024 The Author(s). Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.)- Published
- 2024
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