1. Studies on some enzymes and sialic acid during progestational contraceptive therapy.
- Author
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Chaudhuri C and Mukherjea M
- Subjects
- Acetylcholinesterase blood, Acetylcholinesterase metabolism, Acid Phosphatase blood, Acid Phosphatase metabolism, Adult, Alanine Transaminase blood, Alanine Transaminase metabolism, Alkaline Phosphatase blood, Alkaline Phosphatase metabolism, Aspartate Aminotransferases blood, Aspartate Aminotransferases metabolism, Enzymes blood, Female, Humans, Liver metabolism, N-Acetylneuraminic Acid, Norethindrone metabolism, Norethindrone pharmacology, Sialic Acids blood, Enzymes metabolism, Liver drug effects, Norethindrone analogs & derivatives, Sialic Acids metabolism
- Abstract
Injectable progestogen, norethisterone enanthate (NET-EN, 200 mg/ml at 60-day intervals), was administered to one-hundred-fifty women for two years as a method of contraception. Blood levels of acid phosphatase (ACP), alkaline phosphatase (AP), glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), acetylcholinesterase (AChE) and sialic acid were determined in all the subjects to ascertain whether NET-EN therapy causes any adverse metabolic effect or damage to the functional status of the liver. NET-EN contraception did not alter the liver function enzymes, but there is a significant increase (P less than 0.001) in AChE activity after two years. Serum sialic acid level showed a transient increase up to one year, which however returned to control level later. The mechanism responsible for these changes and whether the rise in sialic acid and AChE activity are related to any pathological condition remain unclear at this stage.
- Published
- 1984
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