1. SerpinB3 administration protects liver against ischemia-reperfusion injury.
- Author
-
Turato C, Vairetti M, Cagna M, Biasiolo A, Ferrigno A, Quarta S, Ruvoletto M, De Siervi S, Pontisso P, and Di Pasqua LG
- Subjects
- Rats, Animals, Ischemia metabolism, Liver, Reperfusion Injury prevention & control, Reperfusion Injury metabolism
- Abstract
We have investigated the change in SerpinB3 during hepatic ischemia and the potential role of its antiprotease activity in cell protection by the administration of wild-type SerpinB3 (SerpinB3-WT) or active loop-deleted recombinant SerpinB3 protein (SerpinB3-D) in a rat model of ischemia (60 min)/reperfusion (60 min) (I/R). A time-dependent increase of SerpinB3, both at transcription and protein level, was found in ischemic livers after 60, 120 and 180 min. SerpinB3-WT decreased polymorphonuclear cell infiltration and serum enzymes and increased ATP when compared with I/R group. These events were not obtained using SerpinB3-D. No significant changes in both liver SerpinB3 mRNA and protein were found in all I/R groups considered. The present data show that the administration of SerpinB3-WT reduced the I/R injury and this effect appears to be dependent on its anti-protease activity.
- Published
- 2022
- Full Text
- View/download PDF