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1. Gamma-irradiation effects on phosphatidylcholine multilayer liposomes: calorimetric, NMR, and spectrofluorimetric studies.

Author

Ianzini F, Guidoni L, Indovina PL, Viti V, Erriu G, Onnis S, and Randaccio P

Subjects
Calorimetry, Differential Scanning, Diphenylhexatriene, Fluorescence Polarization, Gamma Rays, Magnetic Resonance Spectroscopy, Liposomes radiation effects, Phosphatidylcholines radiation effects
Abstract

Chemical and structural modifications in multilayer liposomes of synthetic phosphatidylcholine induced by gamma irradiation are investigated with different techniques. Fluorescence anisotropy of the DPH probe and differential scanning calorimetry reveal a broadening of the main lipid transition and the disappearance of pretransition. Fluorescence anisotropy is shown to be higher in the irradiated sample and particularly so at low temperatures. NMR and TLC results show that lysolecithin and palmitic acid are formed with a consequent change in bilayer organization. The possibility that these modifications may account for the permeability variations observed in irradiated natural membranes is discussed.

Published
1984

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