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Serum lipids were estimated in patients with renal amyloidosis (RA): 21 with familial Mediterranean fever (FMF) and 24 with secondary renal amyloidosis versus FMF patients without renal dysfunction or having chronic glomerular nephritis. All the RA patients had dyslipidemia of atherogenic nature the severity of which correlated with that of renal disorder. Our results showed the presence of dyslipidemia early during RA course. It is renal involvement that results in dyslipidemia observed in FMF patients.

A study was made of urine lipids and their fractions in chronic glomerulonephritis (CGN) and renal amyloidosis with nephrotic syndrome (NS). 91 patients suffering from NS were examined. 2 subgroups were distinguished among these patients: with CGN of the nephrotic type and with the nephrotic stage of renal amyloidosis. The reference groups were made up of patients with latent CGN and healthy subjects. Measurements were made in the blood and urine of total lipids (TL) and their fractions--phospholipids (LP), free cholesterol (FC), mono- and diglycerides, triglycerides (TG), and cholesterol esters (CE). The presence of the NS was attended by a rise in the blood of TL concentration, relative content of FC, TG and by a decline of RL and CE, with the decrease of the relative content being more manifest in amyloidosis. Nephrotic lipiduria was largely characterized by an increase of the concentration of TL and of the relative content of PL, with the changes of the latter parameter being mostly characteristic of CGN patients. Thus, NS was associated with a high excretion of lipids with urine which is likely to reflect their elevated filtration under nephrotic hyperlipidemia. Still, in nephropathies whose pathogenesis is determined by an important role of inflammatory and membrane-destructive processes, of definite role is also the local (renal) formation of PL.

The main classes of serum lipids (fatty acids, phospholipids, triglycerides, cholesterol) were studied and compared in 36 patients aged 20 to 41 years with the renal hypertensive syndrome of different etiology, in 25 patients aged 30 to 51 years with essential hypertension, and in 20 practically healthy subjects aged 20 to 42 years. The mechanism of changes in the content of serum lipids in different diseases associated with the hypertensive renal syndrome and in patients with essential hypertension allows an assumption that these changes are linked to a large degree with arterial hypertension.

A study was made of the content of blood lipids in patients with associated chronic nephritis and arterial hypertension (AH). It has been established that the reduction of arterial pressure as a result of hypotensive therapy (administration of central action drugs, vasodilators of direct action, calcium antagonists, blockers of the angiotensin-transforming enzyme) was followed by a decrease in the blood of the concentration of fatty acids, glycerin, triglycerides, low density lipoproteins, total cholesterol, free cholesterol, phospholipids, characteristics of lipid peroxidation and by the rise of cholesterol concentration in high density lipoproteins. The data obtained are of clinical importance in view of the possibility of correcting dyslipidemia in patients with associated chronic nephritis and arterial hypertension during hypotensive treatment.