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Copyright of Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi is the property of Istanbul Gelisim Universitesi Saglik Bilimleri Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Edaravone (3-methyl-1 -phenyl-2-pyrazolin-5-on) is a potent free radical scavenger and has the antioxidant ability to inhibit lipid peroxidation. Valproic acid (VPA) is a branced-chain carboxylic acid that is widely used as an anti-convulsant for the treatment of epilepsy. It is also interestingly used in other diseases such as bipolar psychiatric disorders and migraine. In this study, the effect of edaravone on gingival tissue damage parameters in VPA induced toxicity was investigated. Female rats were randomly divided into four groups. Group I was intact control animals. Group II was given only VPA (0.5 g/kg/day) for seven days. Group III was given only edaravone (30 mg/kg/day) for seven days. Group IV was given VPA +edaravone (in the same dose and time). Edaravone and VPA were given intraperitoneally. On the eighth day of experiment, all of the animals were fasted overnight and then sacrificed under ether anesthesia. Gingival tissue samples were taken from animals and homogenized. Total protein and lipid peroxidation levels (LPO) and tissue factor activity (TFa), myeloperoxidase (MPO) and alkaline phosphatase activities (ALP) were determined in gingival tissue homogenates. LPO, MPO, ALP and TFa increased in VPA given group. The increases in MPO and TFa activities were statistically significant compared to control group (p<0,01). Edaravone treatment lead to decreases in these parameters. This decrease was found to be statistically significant for MPO (p<0,01). As a conclusion VPA increased gingival tissue damage by causing oxidative stress whereas edaravone tended to reverse these effects. More detailed studies are needed. [ABSTRACT FROM AUTHOR]