1. Dynamics of LPO products and oxidative modification of proteins in human brain during postnatal development.
- Author
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Volchegorskii IA, Malinovskaya NV, Shumelyova OV, and Shiemyakov SE
- Subjects
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Fetus metabolism, Humans, Infant, Infant, Newborn, Male, Nerve Tissue Proteins chemistry, Oxidation-Reduction, Tissue Distribution, Brain growth & development, Brain metabolism, Lipid Peroxidation, Nerve Tissue Proteins metabolism
- Abstract
Opposite changes in the content of LPO products and products of oxidative modification of proteins were detected in human brain structures in the course of postnatal development. A clear-cut ontogenetic reduction of LPO products was observed in field 17 of the cortex, archicortex structures, and in the hypothalamus. Age-specific increase in the levels of products of oxidative modification of proteins was recorded in all compartments of the brain; it peaked by the age of 12-21 years and was most pronounced (4-6-fold) in the visual cortex, hippocampus, diencephalic and pontobulbar compartments of the brain.
- Published
- 2007
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