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Your search keyword '"Baur, Max"' showing total 11 results
Start Over Author "Baur, Max" Topic linkage disequilibrium
11 results on '"Baur, Max"'

1. Efficient Strategy for Detecting Gene x Gene Joint Action and Its Application in Schizophrenia

Author

Won, Sungho, Kwon, Min-Seok, Baur, Max, Uitterlinden, Andre G, Hofmann, A., Lange, Christoph, Investigators, GROUP, Kahn, René S, Linszen, Don H, van Os, Jim, Wiersma, Durk, Bruggeman, Richard, Mattheisen, Manuel, Cahn, Wiepke, de Haan, Lieuwe, Krabbendam, Lydia, Myin-Germeys, Inez, Park, Suyeon, Park, Changsoon, Kihara, Daisuke, Cichon, Sven, Ophoff, Roel, Nöthen, Markus M, Rietschel, Marcella, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Adult Psychiatry, Amsterdam Neuroscience, Internal Medicine, and Epidemiology

Subjects
Linkage disequilibrium, Epidemiology, Genome-wide association study, genetics [Genetic Loci], Computational biology, Biology, minor allele frequency, methods [Genome-Wide Association Study], Polymorphism, Single Nucleotide, Statistical power, Gene Frequency, Genetic model, Humans, genetics [Schizophrenia], Genetic Predisposition to Disease, ddc:610, genetics [Genome, Human], genetics [Genetic Predisposition to Disease], Gene, Allele frequency, Genetics (clinical), Genetic association, Genetics, Models, Genetic, Genome, Human, Hardy-Weinberg disequilibrium, Epistasis, Genetic, gene x gene joint action, Minor allele frequency, Genes, Genetic Loci, Case-Control Studies, genetics [Polymorphism, Single Nucleotide], Schizophrenia, genetics [Gene Frequency], genetics [Epistasis, Genetic], genetics [Linkage Disequilibrium], linkage disequilibrium, Genome-Wide Association Study
Abstract

We propose a new approach to detect gene ? gene joint action in genome-wide association studies (GWASs) for case-control designs. This approach offers an exhaustive search for all two-way joint action (including, as a special case, single gene action) that is computationally feasible at the genome-wide level and has reasonable statistical power under most genetic models. We found that the presence of any gene ? gene joint action may imply differences in three types of genetic components: the minor allele frequencies and the amounts of Hardy-Weinberg disequilibrium may differ between cases and controls, and between the two genetic loci the degree of linkage disequilibrium may differ between cases and controls. Using Fisher's method, it is possible to combine the different sources of genetic information in an overall test for detecting gene ? gene joint action. The proposed statistical analysis is efficient and its simplicity makes it applicable to GWASs. In the current study, we applied the proposed approach to a GWAS on schizophrenia and found several potential gene ? gene interactions. Our application illustrates the practical advantage of the proposed method. ? 2013

Published
2014
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3. Population Analysis on the Basis of Deduced Haplotypes from Random Families

Author

Baur, M. P., Neugebauer, M., Deppe, H., Sigmund, M., Luton, T., Mayr, W. R., Albert, E. D., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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4. Linkage Between HLA-A, C, B, Bf and DR Alleles: Haplotype Study of Healthy Families by Factorial Correspondence Analysis

Author

Grange, D., Tongio, M. M., Hauptmann, G., Uring-Lambert, B., North, M. L., Mayer, S., Neugebauer, M., Baur, M. P., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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5. Antigen Report: HLA-Cw3

Author

Campbell, E. M., du Toit, E. D., Tongio, M. M., Urlacher, A., Mayer, S., Mayr, W. R., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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6. Antigen Report: HLA-Bw61

Author

Goldmann, S. F., Middleton, D., Kennedy, L. J., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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7. Antigen Report: HLA-Aw33

Author

Mazzilli, M. C., Neri, T. M., Adorno, D., Amoroso, A., Barocci, S., Martorell, J., Ferrara, G. B., Gandini, E., Savi, M., Vives, J., Longo, A., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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8. HLA-DR, DQ, and Dw Relationships

Author

Schreuder, G. M. T., Degos, L., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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9. Antigen Report: HLA-A24

Author

Singal, D. P., D’Souza, M., Bétuel, H., Gebuhrer, L., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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10. Antigen Report: HLA-A32

Author

Vives, J., Neumeyer, H., Martorell, J., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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11. Antigen Report: A9.3

Author

Singal, D. P., D’Souza, M., Bétuel, H., Gebuhrer, L., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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