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[Display omitted] • A SnO 2 QDs-MXene composite was synthesized for electrochemical detection of luteolin. • The expanded d-spacing of MXene providing abundant active sites for detection. • The SnO 2 QDs-MXene/GCE electrode showed an ultra-low LOD of 0.14 nM. • The SnO 2 QDs-MXene/GCE electrode achieve accurate detection in actual samples. Although there have been advancements in electrochemical catalysts for luteolin detection, their practical use is constrained by low sensitivity, inadequate selectivity, and unsatisfactory limit of detection. MXene, a class of 2D materials, possesses exceptional physical–chemical properties that make it highly suitable for electrochemical detection. Nevertheless, the self-stacking and limited interlayer spacing of MXene impede its extensive application in electrochemical detection. Herein, a SnO 2 QDs-MXene composite is synthesized for selective electrochemical detection of luteolin. Inserting SnO 2 QDs between tightly stacked MXene layers expands the d-spacing of MXene, enhancing the specific surface area and enabling abundant active sites for redox reactions. The inclusion of MXene in the modified SnO 2 QDs-MXene/GCE electrode significantly enhances electron transfer. As a result, the electrode demonstrates exceptional luteolin detection capabilities, including a wide linear range (0.1–1200 nM), high sensitivity (12.4 μA μM−1), and an ultra-low limit of detection (0.14 nM). Additionally, the SnO 2 QDs-MXene/GCE electrode exhibits good repeatability, excellent reproducibility, remarkable stability, and high selectivity, making it suitable for practical sample analysis. This research contributes to advancing ultra-low limit of detection sensors for accurate luteolin detection. [ABSTRACT FROM AUTHOR]

[Display omitted] • A SnO 2 quantum dots modified glass carbon electrode is developed. • The SnO 2 QDs/GCE possesses an ultra-low LOD of 0.25 nM toward luteolin. • The SnO 2 QDs/GCE electrode achieves accurate detection of luteolin in actual samples. Although most of the composite based electrocatalysts for determination of luteolin has been developed, the unsatisfactory limit of detection (LOD) and narrow linear range originated from the unstable interface among each component limit their further application. Herein, a SnO 2 quantum dots modified glass carbon electrode (SnO 2 QDs/GCE) is developed for selective detection of luteolin. The electrochemical behavior of luteolin on SnO 2 QDs/GCE indicates that the redox process involves participating of two-electrons/double-protons. The big specific surface area of SnO 2 QDs provides sufficient active sites for the redox reaction of luteolin. On this bases, an ultra-low LOD of 0.25 nM as well as a large linear range of 0.1–1200 nM is obtained for detection of luteolin. Besides, the influence of several coexisting compounds and common ions on the detection of luteolin was evaluated, and no obvious interference was found. Finally, the SnO 2 QDs/GCE electrode achieves accurate detection of luteolin in actual samples including orange, lemon and carrot juices. This work provides new strategy for the determination of luteolin in complex systems. [ABSTRACT FROM AUTHOR]