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[Display omitted] • Enzyme synergy is highly substrate dependent. • High degrees of synergy do not necessarily lead to high yields. • Homeosynergies between xylanases increase yields the most, up to 57%. • Heterosynergies of ferulic acid esterase and xylanases were found on all substrates. • Synergies of laccase and xylanases exist only for high lignin containing substrates. The success of establishing bioeconomies replacing current economies based on fossil resources largely depends on our ability to degrade recalcitrant lignocellulosic biomass. This study explores the potential of employing various enzymes acting synergistically on previously pretreated agricultural side streams (corn bran, oat hull, soluble and insoluble oat bran). Degrees of synergy (oligosaccharide yield obtained with the enzyme combination divided by the sum of yields obtained with individual enzymes) of up to 88 were obtained. Combinations of a ferulic acid esterase and xylanases resulted in synergy on all substrates, while a laccase and xylanases only acted synergistically on the more recalcitrant substrates. Synergy between different xylanases (glycoside hydrolase (GH) families 5 and 11) was observed particularly on oat hulls, producing a yield of 57%. The synergistic ability of the enzymes was found to be partly due to the increased enzyme stability when in combination with the substrates. [ABSTRACT FROM AUTHOR]