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6 results on '"Marver HS"'

1. Delta-aminolevulinic acid synthetase. II. Induction in rat liver.

Author

Marver HS, Collins A, Tschudy DP, and Rechcigl M Jr

Subjects
Animals, Dactinomycin pharmacology, Enzyme Induction, Fluorouracil pharmacology, Glucose pharmacology, In Vitro Techniques, Levulinic Acids, Puromycin pharmacology, RNA, Messenger metabolism, Rats, Hypnotics and Sedatives pharmacology, Ligases biosynthesis, Liver enzymology
Published
1966

6. Coordinate synthesis of heme and apoenzyme in the formation of tryptophan pyrrolase.

Author

Marver HS, Tschudy DP, Perlroth MG, and Collins A

Subjects
Amino Acids, Animals, Enzyme Repression, Female, Levulinic Acids, Rats, Tryptophan Oxygenase biosynthesis, Heme biosynthesis, Ligases biosynthesis, Liver enzymology, Oxygenases biosynthesis
Abstract

Reciprocal control mechanisms between hemoprotein and 8-aminolevulinic acid synthetase take part in coordinate synthesis of the heme and apoenzyme moieties of tryptophan pyrrolase. Stimulation of heme biosynthesis increases tryptophan pyrrolase, whereas enhancement of heme binding by apotryptophan pyrrolase secondarily increases the formation of delta-aminolevulinic acid synthetase, the rate-limiting enzyme in heme formation. Tryptophan-mediated induction of delta-aminolevulinic acid synthetase suggests that heme participates in repression of that enzyme

Published
1966
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