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Start Over Author "V. Onofrj" Topic lewy body disease
4 results on '"V. Onofrj"'

1. Visual hallucinations in PD and Lewy body dementias: old and new hypotheses.

Author

Onofrj M, Taylor JP, Monaco D, Franciotti R, Anzellotti F, Bonanni L, Onofrj V, and Thomas A

Subjects
Hallucinations complications, Hallucinations diagnosis, Humans, Lewy Body Disease complications, Neural Pathways physiopathology, Parkinson Disease complications, Psychiatric Status Rating Scales, Sleep Wake Disorders complications, Sleep Wake Disorders psychology, Attention physiology, Hallucinations physiopathology, Lewy Body Disease psychology, Parkinson Disease psychology
Abstract

Visual Hallucinations (VH) are a common non-motor symptom of Parkinson's Disease (PD) and the Lewy body dementias (LBD) of Parkinson's disease with dementia (PDD) and Dementia with Lewy Bodies (DLB). The origin of VH in PD and LBD is debated: earlier studies considered a number of different possible mechanisms underlying VH including visual disorders, Rapid Eye Movement (REM) Sleep Intrusions, dysfunctions of top down or bottom up visual pathways, and neurotransmitter imbalance. More recently newer hypotheses introduce, among the possible mechanisms of VH, the role of attention networks (ventral and dorsal) and of the Default Mode Network (DMN) a network that is inhibited during attentional tasks and becomes active during rest and self referential imagery. Persistent DMN activity during active tasks with dysfunctional imbalance of dorsal and ventral attentional networks represents a new hypothesis on the mechanism of VH. We review the different methods used to classify VH and discuss reports supporting or challenging the different hypothetical mechanisms of VH.

Published
2013
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3. Revisiting P300 cognitive studies for dementia diagnosis: Early dementia with Lewy bodies (DLB) and Alzheimer disease (AD).

Author

Bonanni L, Franciotti R, Onofrj V, Anzellotti F, Mancino E, Monaco D, Gambi F, Manzoli L, Thomas A, and Onofrj M

Subjects
Aged, Alzheimer Disease psychology, Cognition Disorders diagnosis, Female, Humans, Lewy Body Disease psychology, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Reproducibility of Results, Socioeconomic Factors, Alzheimer Disease diagnosis, Alzheimer Disease physiopathology, Cognition physiology, Electroencephalography methods, Event-Related Potentials, P300 physiology, Lewy Body Disease diagnosis, Lewy Body Disease physiopathology
Abstract

Aims of the Study: Earlier P300 studies were conducted when the prevalence of dementia with Lewy Bodies (DLB) was unknown. Our study aims to examine whether P300 abnormalities are present in DLB and to evidence possible differences between DLB and Alzheimer's disease (AD). A second aim of this study is to look for correlations between P300 recordings and EEG, as abnormal EEG variability has been described in DLB., Patients and Methods: Auditory P300 responses were recorded by a classic oddball paradigm in 50 controls, in 36 DLB patients, and in 40 AD patients with MMSE>20., Results: Reliable auditory P300 responses were obtained in 26 DLB (72%), 33 AD (82.5%), and 46 controls (92%). P300 was more delayed and had lower amplitude in DLB compared to AD groups. P300 topography was also different as the anterior-to-posterior scalp amplitude gradient was reversed in DLB. P300 latency correlated with neuropsychological test scores and with EEG variables. Gradient inversion and delayed P300 responses in frontal derivations evidenced differences between DLB and AD patients with a sensitivity of 70% and a specificity of 97%., Conclusions: P300 recordings are abnormal in DLB and can be useful to distinguish DLB from AD., (Copyright © 2010 Elsevier Masson SAS. All rights reserved.)

Published
2010
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4. Revisiting P300 cognitive studies for dementia diagnosis: Early dementia with Lewy bodies (DLB) and Alzheimer disease (AD)

Author

V. Onofrj, E. Mancino, Laura Bonanni, Lamberto Manzoli, Astrid Thomas, Marco Onofrj, Francesca Anzellotti, Francesco Gambi, D. Monaco, and Raffaella Franciotti

Subjects
Lewy Body Disease, Male, medicine.medical_specialty, Socio-culturale, Audiology, Electroencephalography, Neuropsychological Tests, behavioral disciplines and activities, Central nervous system disease, Degenerative disease, Cognition, Alzheimer Disease, Physiology (medical), mental disorders, medicine, Humans, Oddball paradigm, Aged, Psychiatric Status Rating Scales, medicine.diagnostic_test, Dementia with Lewy bodies, Reproducibility of Results, General Medicine, Neuropsychological test, Middle Aged, medicine.disease, Event-Related Potentials, P300, nervous system diseases, medicine.anatomical_structure, nervous system, Neurology, Socioeconomic Factors, Scalp, Female, Neurology (clinical), Alzheimer's disease, Psychology, Cognition Disorders, Neuroscience
Abstract

Summary Aims of the study Earlier P300 studies were conducted when the prevalence of dementia with Lewy Bodies (DLB) was unknown. Our study aims to examine whether P300 abnormalities are present in DLB and to evidence possible differences between DLB and Alzheimer's disease (AD). A second aim of this study is to look for correlations between P300 recordings and EEG, as abnormal EEG variability has been described in DLB. Patients and methods Auditory P300 responses were recorded by a classic oddball paradigm in 50 controls, in 36 DLB patients, and in 40 AD patients with MMSE > 20. Results Reliable auditory P300 responses were obtained in 26 DLB (72%), 33 AD (82.5%), and 46 controls (92%). P300 was more delayed and had lower amplitude in DLB compared to AD groups. P300 topography was also different as the anterior-to-posterior scalp amplitude gradient was reversed in DLB. P300 latency correlated with neuropsychological test scores and with EEG variables. Gradient inversion and delayed P300 responses in frontal derivations evidenced differences between DLB and AD patients with a sensitivity of 70% and a specificity of 97%. Conclusions P300 recordings are abnormal in DLB and can be useful to distinguish DLB from AD.

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