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Objective: Leptin is an adipokine that plays a key role regulating body weight. Common polymorphisms in the leptin (LEP) gene and leptin receptor (LEPR) gene are associated with obesity and its complications. This study investigated associations between the LEPR Q223R and LEP G-2548A polymorphisms and body mass index (BMI), plasma leptin levels, and biochemical parameters in postmenopausal women. Material and Method: The study included 115 obese and 85 non-obese postmenopausal women. The G-2548A and Q223R polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. Plasma leptin levels, serum lipids, and anthropometric parameters were measured. Results: Our results showed no association between obesity and the G-2548A and Q223R polymorphisms. The Q223R and G-2548A polymorphisms were significantly associated with total cholesterol in both groups. The G-2548A polymorphism was associated with high LDL-cholesterol levels in the non-obese group (p<0.001). Additionally, the Q223R polymorphism was associated with leptin levels (p=0.021), particularly in the obese group. Conclusion: Our results suggest that the G-2548A and Q223R polymorphisms had no direct association with obesity in postmenopausal women. However, they had significant effects on lipid profiles in obese and non-obese subjects. [ABSTRACT FROM AUTHOR]

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