1. Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes.
- Author
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Al-Qahtani A, Siddiqui YM, Bekhit AA, El-Sayed OA, Aboul-Enein HY, and Al-Ahdalb MN
- Subjects
- Animals, Antiprotozoal Agents chemistry, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Leishmania donovani growth & development, Pyrazoles chemistry, Quinolines chemistry, Antiprotozoal Agents pharmacology, Leishmania donovani drug effects, Pyrazoles pharmacology, Quinolines pharmacology
- Abstract
A screening study was conducted to examine the effect of a series of synthesized pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes. Sixteen compounds were tested, ten of which showed an inhibitory effect on the growth of promastigotes. Compound 1 demonstrated potent antileishmanial activity, followed by compounds 3 and 7. Some compounds showed less significant activities, while others exhibited little or no activity. Some of these compounds may be potential candidates for future treatment of leishmaniasis.
- Published
- 2005
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