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The relationship was studied between the ankle-arm index (K/R) and whole blood and plasma viscosity in patients suffering from diabetes mellitus type II with ischemia of lower extremities. The measurements were carried out in 96 patients (80 males and 16 females), of whom 72 were in stage II of Fontaine progression. Immediately after determination of the K/R index blood was taken from vena mediana cubiti adding Na2EDTA for rheological test. Whole blood viscosity was measured with a Low-Shear 100 Contraves viscometer immediately after sampling, and plasma viscosity was measured with a capillary viscometer of Ubbvelohd within 2 hours after sampling. By the method of regression analysis and linear correlation it was found that increased whole blood and plasma viscosity significantly correlated with reduced K/R value in the patients. The obtained results are analysed in biophysical and clinical aspects.

Ten injections of O3 into femoral arteries were administered to 50 patients with atherosclerotic ischemia of the lower extremities and to 49 diabetic patients. All patients were assessed clinically with the ankle-arm index, measurement of intermittent claudication distance prior to and after the treatment. The treatment showed a significant improvement in both groups manifested by an increase in ankle-arm index, and prolongation of the intermittent claudication distance by more than twice. The treatment of atherosclerotic ischemia of the lower extremities with O3 is both valuable and safe.

In 50 subjects with arteriosclerotic ischaemia of the lower extremities and 41 subjects with diabetes mellitus ozone was applied intra-arterially. Before and after the treatment serum lipids concentration was examined. In the group with arteriosclerotic ischemia significant decrease in cholesterol level and both his fractions was seen. Whereas in the group with diabetes the cholesterol LDL was significantly reduced. In both groups total lipids level serum was decreased. It suggests that ++ozone therapy set back the arteriosclerosis progress, normalized some parameters of lipid metabolism and improved HDL to LDL cholesterol fractions relationship.