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Dermatofibromas are common, benign, fibrohistiocytic cutaneous tumor. Although the diagnosis is usually made clinically, some atypical characteristics are seen in these tumors and can be a real challenge. Dermatoscopy can be very useful in such situations. However, some dermatofibromas are simulators of malignant skin tumors and therefore require biopsy for histopathological study.

La fibrosis sistémica nefrogénica (FSN) es una entidad infrecuente, que se desarrolla en pacientes insuficientes renales en diálisis, vinculándose su etiopatogenia con diversos factores tales como el uso de gadolinio intravenoso, el antecedente de cirugías vasculares, etc.El Tamoxifeno, es un modulador selectivo (inhibición competitiva) de los receptores estrogénicos, que posee propiedades antifibróticas las cuales se emplean para el tratamiento de entidades tales como: fibrosis retroperitoneal, esclerosis peritoneal asociada a diálisis peritoneal, tumores desmoides y en algunos casos de esclerodermia.En el presente articulo presentamos la hipótesis original de que el tamoxifeno, por su propiedades fibrinolíticas, podría ser una terapia no inmunosupresora potencialmente útil para el tratamiento de la fibrosis sistémica nefrogénica, evitándose desde ya su uso en pacientes portadores de contraindicaciones para recibirlo.

Nephrogenic systemic fibrosis is (NSF) a rare entity which develops in patients with renal failure undergoing dialysis, and its etiology is related to several factors such as the use of intravenous gadolinium, vascular surgeries, etc.Tamoxifen, is a selective modulator (competitive inhibition) of estrogen receptors, and it has antifibrotic properties which are used for treating retroperitoneal fibrosis, peritoneal sclerosis associated to peritoneal dialysis, desmoids tumors and in some cases of sclerodermia.In the present article, it is presented the hypothesis of a potential use of tamoxifen as a non immunosuppressant treatment for NSF in patients who have no contraindication for receiving it.