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We studied epizootiology and clinical-morphological characteristics of salmonella in pig farms. Salmonella in pig farms often recorded under adverse conditions of feeding and housing of animals. The disease in pigs took place in acute, sub-acute and chronic forms.

We studied etiological factors and clinical-morphological expression of chlamydia in pig farms. The disease was observed in the farms, regardless of the season, but more often in winter-spring period. Upon initial appearance of the disease in farms with single sows gestating in recent weeks registered abortions. In pigs-sosunov chlamydia proceeded against the defeat of the respiratory, digestive organs.

Intramuscular injection of the drug on the basis of compositional enrofloxacin and colistin in doses of 0,5, 1,0 and 2,5 ml per 10 kg weight of the animal within 20 days of piglets did not violate arhitektotoniku girder structure of the organ and morphometric parameters of hepatocytes. Use of the drug did not alter the amount and distribution of the lobules of the liver glycogen and lipid content of DNA in the nuclei and RNA in the cytoplasm of hepatocytes, as well as the amount of total proteins in hepatocytes. The composite preparation on the basis of enrofloxacin and colistin of piglets had no effect on the structural organization of the mucosa of the small intestine and morphometric parameters, as well as DNA content nuclei and RNA in the cytoplasm. It does not change the core area, area and cytoplasmic-nuclear ratio of enterocytes apical and lateral surfaces of villi and crypts.

The carried out research of local - irritant, skin - resorvent and allergic effect of injection form of drug induding enrofloxacin and colistin in animals. It has slight irritant effect on the skin and doesn't have any skin - resorvent and allergic properties. The influence of composition of enrofloxacin with colistin on the physiological status of animals. It was found that an intramuscular injection of the drug in doses of 0,5 and 1,0 ml per 10 kg bodyweight doesn't have any negative impact on the overall condition of laboratory animals, does not alter the morphological and biochemical indices of their blood. Exchange of drug in a therapeutic dose does not change.

We studied the acute and sub-chronical toxicity of the drugs on the basis of еnrofloxacin and colistin in laboratory animals. The drug according to GOST 12.1.007-76 apply to Class 3 danger - little dangerous. We studied the influence of the drug on the basis of composite еnrofloxacin and colistin at doses 0,5, 1,0 and 5,0 ml per 10 kg body weight on the clinical and biochemical indicators of the blood in piglets and calves. It was found that the therapeutical efficacy of new drug with kolibakterioze calves equaled 90,7%, piglets - 91,4%, while the effectiveness dizparcolum (base product) was 78,9% and 80,0% respectively.