Search

The aim of the study was proof of efficacy and safety of the drug Frinozol nasal spray in patients with acute respiratory infection (acute rhinitis). PATIENTS AND METHODS: A randomized open-label study with active control included 134 ambulatory patients: men and women aged 18 to 65 years with acute upper respiratory tract infection (acute rhinitis) lasting no more than 48 hours before inclusion into the study. Patients were randomized in two groups: group 1 took Frinozol nasal spray 2 sprays per each nostril three times a day for 7 days, subjects randomized to the group 2 took Vibrocil at the same dose and treatment regimen. The primary efficacy endpoint in the study was assessment of the dynamics of symptoms such as nasal congestion, rhinorrhea, itching in the nose and hyposmia using 10 cm VAS in 1 day after the start of treatment compared to the baseline. Secondary endpoints included assessment of the dynamics of nasal symptoms after 7 days of treatment, changes in the values of the Congestion Quantifier 5, CQ-5 questionnaire and evaluation of the effectiveness by the investigator. Safety analysis was carried out throughout the study and included the assessment of adverse events, laboratory data, vital signs, ECG assessment. RESULTS: According to the results of the study and comparative analysis of the primary (assessment of the dynamics of nasal symptoms on a 10 cm visual analogue scale 1 day after the start of treatment) and secondary efficacy endpoints as well as a comprehensive safety analysis, it can be concluded that the study drug is not inferior to the reference drug. Thus, the new combination Frinozol nasal spray is an effective and safe treatment for patients with acute respiratory infections.Цель исследования - доказательство эффективности и безопасности препарата Фринозол спрей назальный у пациентов с острой респираторной инфекцией (острым ринитом). Пациенты и методы. В рандомизированное открытое исследование с активным контролем были включены 134 амбулаторных пациента - мужчины и женщины в возрасте от 18 до 65 лет, с диагнозом острая респираторная инфекция верхних дыхательных путей (острый ринит) длительностью не более 48 ч до включения в исследование. Пациенты были рандомизированы в две группы: 1-я группа пациентов получала Фринозол спрей назальный по 2 впрыскивания в каждый носовой ход трижды в день в течение 7 дней, 2-я - Виброцил в той же дозировке и режиме терапии. Первичной конечной точкой эффективности в исследовании была оценка динамики таких симптомов, как заложенность носа, ринорея, зуд в носу и гипосмия по визуальной аналоговой шкале (ВАШ) через 1 день после начала лечения по сравнению с исходным уровнем. Вторичные конечные точки включали оценку динамики назальных симптомов по ВАШ через 7 дней терапии, изменения значений показателей опросника Congestion Quantifier 5 (CQ-5) и оценку эффективности исследователем. Анализ безопасности осуществлялся на протяжении всего исследования и включал оценку нежелательных явлений, лабораторных данных, показателей жизненно важных функций, оценку ЭКГ. Результаты. По результатам проведенного исследования и сравнительного анализа первичной (оценка динамики назальных симптомов ВАШ через 1 день после начала лечения) и вторичных конечных точек эффективности, а также проведенного комплексного анализа безопасности, можно сделать вывод о том, что исследуемый препарат не уступает препарату сравнения. Таким образом, новый комбинированный препарат Фринозол спрей назальный является эффективным и безопасным методом лечения пациентов с острыми респираторными инфекциями.

Lord Diplock, in Orakpo v Manson Investments, used language that indicated that the range of restitution, or unjust enrichment, is limited. Lord Goff, on several occasions, has been more amenable to the idea that, should a remedy be desirable in the circumstances of a particular case, the concept of restitution could, and should be utilised in a creative manner. Canadian judges have been more inclined than those in England to adopt the latter approach. As one of them once said: ‘Just as the categories of negligence are never closed, neither can those of restitution’. In more recent judgments Canadian courts have continued to show their willingness to extend the scope of restitution in two ways: (i) by the enunciation of a general concept of unjust enrichment that underlies the idea of restitution; (ii) by a broader, more innovative use of the traditional doctrine of constructive trust. Both these developments stem from a fundamental premise as to the ‘equitable’ nature of restitution.

In this review the wide spectrum of properties of filled polymer systems is generalized. Classical and modern conceptions dealing with the influence of the boundary layer and filler on melting and crystallization of the polymer matrix. Polymer properties in the melted and condensed state are considered, attention being given to the influence of the filler particle size and shape, the nature of its surface, its structure, and agglomeration on the rheological and mechanical characteristics of composites.

The modif icat ion of polypropylene with different addi t ives, for example , f i l l e r s , p l a s t i c i ze r s , and s tab i l i z e r s , is widely employed for the cont ro l led i m p r o v e m e n t of a se t of its p r o p e r t i e s . Among other things, the f r eeze r e s i s t a n c e and light s tabi l i ty a r e i n c r e a s e d by the introduction of a lkal i sulfate lignin and a l o w m o l e c u la r -we igh t p l a s t i c i z e r [1-41.

The extent to which parties to a contract are free to arrange the existence and scope of their respective liabilities by the use of exemption clauses under a contract is a concern touching an unclear area of the law. Professor Fridman, recently appointed to the Faculty of Law of The University of Alberta and commencing tenure in the 1969-70 academic year, surveys the case law and concludes that proper judicial control of the freedom of contract is essential to the protection and future usefulness of that freedom.

In this article, Professor Fridman criticizes the Supreme Court of Canada for what he feels to be its lack of independence of thought and reasoning in its tendency to apply English precedents rather than to develop its own opinions in the area of contracts, quasi-contracts and torts. He recommends that the Court should analyse problems in depth at every opportunity afforded to it so as to provide greater guid ance for the lower Courts of Canada.