1. Component-resolved immunologic modifications, efficacy, and tolerance of latex sublingual immunotherapy in children.
- Author
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Lasa Luaces EM, Tabar Purroy AI, García Figueroa BE, Anda Apiñaniz M, Sanz Laruga ML, Raulf-Heimsoth M, and Barber Hernández D
- Subjects
- Administration, Sublingual, Adolescent, Allergens adverse effects, Allergens immunology, Antigens, Plant adverse effects, Antigens, Plant immunology, Antimicrobial Cationic Peptides administration & dosage, Antimicrobial Cationic Peptides adverse effects, Basophils immunology, Case-Control Studies, Child, Child, Preschool, Female, Humans, Immune Tolerance immunology, Immunoglobulin E blood, Immunoglobulin G blood, Latex Hypersensitivity immunology, Male, Plant Lectins administration & dosage, Plant Lectins adverse effects, Plant Proteins adverse effects, Plant Proteins immunology, Prospective Studies, Rubber administration & dosage, Rubber chemistry, Skin Tests, Treatment Outcome, Allergens administration & dosage, Antigens, Plant administration & dosage, Antimicrobial Cationic Peptides immunology, Desensitization, Immunologic methods, Latex Hypersensitivity therapy, Plant Lectins immunology, Plant Proteins administration & dosage
- Abstract
Background: As the frequency of natural rubber latex (NRL) allergy has increased, attempts have been made to diminish exposure in high-risk patients. Despite some good results, complete NRL avoidance was not possible, so latex immunotherapy was developed., Objective: To examine variations in immunologic parameters, clinical efficacy, and safety of NRL sublingual immunotherapy (SLIT)., Methods: This prospective, observational, open, case-control study included 23 patients (18 patients receiving NRL SLIT and 5 controls). Skin prick, conjunctival provocation, and in-use tests with NRL, specific IgE and specific IgG4 to NRL, specific IgE to recombinant NRL allergens, and basophil activation test (BAT) with whole latex, natural, and recombinant allergens were performed before immunotherapy (T0) and at 6 (T1) and 12 months (T2) of treatment., Results: Patients were sensitized to Hev b 5, Hev b 6.01, and Hev b 6.02 proteins, optimal for SLIT. Changes in specific IgE were not significant. Increases in specific IgG4 between T1 and T2 were larger in the active group. BAT determinations showed significant decreases in recombinant Hev b 6.01 and natural Hev b 6.02 in the active group at T1 but not at T2. Both groups had new sensitizations at T1 but not at T2. The active group had significant increases in the response threshold in the in vivo tests at T1 and T2. Adverse effects were limited to local reactions., Conclusion: NRL SLIT is effective and safe in children with latex allergy. Our results suggest that specific IgE determinations and BAT measurements to natural and recombinant latex allergens may allow obtaining an allergen-based diagnosis to help determine specific immunotherapy., (Copyright © 2012 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
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