1. Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone.
- Author
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Cole JM, Wood JC, Lopes NC, Poder K, Abel RL, Alatabi S, Bryant JS, Jin A, Kneip S, Mecseki K, Symes DR, Mangles SP, and Najmudin Z
- Subjects
- Absorptiometry, Photon instrumentation, Equipment Design, Equipment Failure Analysis, Humans, Image Enhancement instrumentation, In Vitro Techniques, Reproducibility of Results, Sensitivity and Specificity, Femur diagnostic imaging, Imaging, Three-Dimensional instrumentation, Lasers, Particle Accelerators instrumentation, Tomography, X-Ray Computed instrumentation
- Abstract
A bright μm-sized source of hard synchrotron x-rays (critical energy Ecrit > 30 keV) based on the betatron oscillations of laser wakefield accelerated electrons has been developed. The potential of this source for medical imaging was demonstrated by performing micro-computed tomography of a human femoral trabecular bone sample, allowing full 3D reconstruction to a resolution below 50 μm. The use of a 1 cm long wakefield accelerator means that the length of the beamline (excluding the laser) is dominated by the x-ray imaging distances rather than the electron acceleration distances. The source possesses high peak brightness, which allows each image to be recorded with a single exposure and reduces the time required for a full tomographic scan. These properties make this an interesting laboratory source for many tomographic imaging applications., Competing Interests: The authors declare no competing financial interests.
- Published
- 2015
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