9 results on '"Di Naro E"'
Search Results
2. Outcomes of robotic surgery performed in patients with high BMI class: experience by a single surgeon.
- Author
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Damiani GR, Villa M, Di Naro E, Signorelli M, Corso S, Trojano G, Loverro M, Capursi T, Muzzupapa G, and Pellegrino A
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- Aged, Body Mass Index, Female, Humans, Length of Stay, Middle Aged, Neoplasm Recurrence, Local, Postoperative Complications epidemiology, Prospective Studies, Robotic Surgical Procedures methods, Endometrial Hyperplasia surgery, Endometrial Neoplasms surgery, Hysterectomy methods, Laparoscopy methods, Obesity, Morbid complications
- Abstract
Background: Advanced laparoscopic procedures have been shown to be safe in patients with high Body Mass Index (BMI), but conversion rates remain high. This analysis aimed to evaluate the feasibility and clinical outcomes in terms of long- and short-term complications, pain relief of robotic surgery in morbidly obese patients., Methods: Patients with BMI class I-II-III with endometrial cancer or hyperplasia were treated with robotic hysterectomy (RH). Patients' characteristics, operating room time (OT), type of surgery, length of hospital stay, and incidence of complications were recorded. Records were reviewed for demographic data, medical/surgical history and comorbidities, perioperative findings and outcomes, as well as long-term complications and recurrences. Regarding stage, according to 2009 FIGO, 26 of cases were IA, while eight and five of cases were, respectively, IB, II stage., Results: A total of 87 consecutive RH were analyzed. The more frequent comorbidity was hypertension. Twenty percent of the patients had multiple comorbidities (>2). The mean age was 63±10 years, with a mean BMI of 36±8.2 kg/m2. The more frequent BMI group treated was II class. The median OT was 114 minutes (range: 49-270). According to the Dindo Classification, there were no differences in major or minor complications between the 3 BMI classes. This series had a median follow-up of 60 months (range: 8-96) with an overall survival rate of 100%. The RRH+PLH was feasible and pathology confirmed the adequacy of the surgical specimen, with a median count of 20 nodes., Conclusions: Our data support the adoption of the surgical management of the morbidly obese patient. Although short term complication rates are higher with increasing obesity (II-III class), a majority of procedures can still be completed with minimally invasive approach.
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- 2019
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3. Laparoscopic and vaginal approaches to hysterectomy in the obese.
- Author
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Bogani G, Cromi A, Serati M, Di Naro E, Casarin J, Pinelli C, Uccella S, Leone Roberti Maggiore U, Marconi N, and Ghezzi F
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- Adult, Aged, Body Mass Index, Female, Humans, Length of Stay, Middle Aged, Operative Time, Postoperative Complications epidemiology, Retrospective Studies, Uterine Diseases surgery, Hysterectomy methods, Hysterectomy, Vaginal, Laparoscopy, Obesity complications
- Abstract
Objective: The aim of the study was to compare surgery-related outcomes between laparoscopic (LH) and vaginal (VH) hysterectomy, performed for benign uterine disease (other than pelvic organs prolapse) in obese women., Study Design: Data of consecutive obese (BMI≥30) patients undergoing LH and VH, between 2000 and 2013, were compared using a propensity-matched analysis. One hundred propensity-matched patient pairs (200 patients) undergoing LH (n=100) and VH (n=100) represented the study group., Results: Baseline demographic characteristics were similar between groups. Patients undergoing LH experienced similar operative time (87.5 (25-360) vs. 85 (25-240)min; p=0.28), slightly lower blood loss (100 (10-3200) vs. 150 (10-800)ml; p=0.006) and shorter length of hospital stay (1 (1-5) vs. 2 (1-5) days; p<0.001) than women undergoing VH. There was no statistically significant difference between LH and VH in complication rate (3% for VH vs. 10% for LH; OR: 3.4; 95%CI: 0.95-13.5; p=0.08). At multivariable analysis complication rates increased as BMI increase (OR: 1.01 (1.00-1.02) for 1-unit increase in BMI; p=0.05). Independently, LH correlated with reduced hospital stay (OR: 0.63 (95%CI: 0.49-0.82); p=0.001) and complication rates (OR: 0.91 (95%CI: 0.85-0.97); p=0.01)., Conclusions: In obese women affected by benign uterine disease LH and VH should not be denied on the basis of the mere BMI, per se. In this setting, LH upholds effectiveness of VH, improving postoperative outcomes. However, complication rate increases as BMI increase, regardless surgical route., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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4. Improving standard of care through introduction of laparoscopy for the surgical management of gynecological malignancies.
- Author
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Bogani G, Cromi A, Serati M, Di Naro E, Casarin J, Pinelli C, Candeloro I, Sturla D, and Ghezzi F
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- Adnexal Diseases pathology, Adolescent, Adult, Aged, Aged, 80 and over, Disease Management, Endometrial Neoplasms pathology, Female, Follow-Up Studies, Humans, Length of Stay, Male, Middle Aged, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Operative Time, Prognosis, Retrospective Studies, Uterine Cervical Neoplasms pathology, Young Adult, Adnexal Diseases surgery, Endometrial Neoplasms surgery, Laparoscopy, Neoplasm Recurrence, Local surgery, Postoperative Complications, Standard of Care, Uterine Cervical Neoplasms surgery
- Abstract
Objective: This study aimed to evaluate the impact on perioperative and medium-term oncologic outcomes of the implementation of laparoscopy into a preexisting oncologic setting., Methods: Data from consecutive 736 patients undergoing surgery for apparent early stage gynecological malignancies (endometrial, cervical, and adnexal cancers) between 2000 and 2011 were reviewed. Complications were graded per the Accordion classification. Survival outcomes within the first 5 years were analyzed using Kaplan-Meier method., Results: Overall, 493 (67%), 162 (22%), and 81 (11%) had surgery for apparent early stage endometrial, cervical, and adnexal cancer. We assisted at an increase of the number of patients undergoing surgery via laparoscopy through the years (from 10% in the years 2000-2003 to 82% in years 2008-2011; P < 0.001 for trend); while the need to perform open surgery decreased dramatically (from 83% to 10%; P < 0.001). Vaginal approach was nearly stable over the years (from 7% to 8%; P = 0.76). A marked reduction in estimated blood loss, length of hospital stay, blood transfusions as well as grade greater than or equal to 3 postoperative complications over the years was observed (P < 0.001). Surgical radicality assessed lymph nodes count was not influenced by the introduction of laparoscopic approach (P > 0.05). The introduction of laparoscopy did not adversely affect medium-term (within 5 years) survival outcomes of patients undergoing surgery for apparent early stage cancers of the endometrium, uterine cervix, and adnexa (P > 0.05 log-rank test)., Conclusions: The introduction of laparoscopy into a preexisting oncologic service allows an improvement of standard of care due to a gain in perioperative results, without detriments of medium-term oncologic outcomes.
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- 2015
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5. Hysterectomy in patients with previous cesarean section: comparison between laparoscopic and vaginal approaches.
- Author
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Bogani G, Cromi A, Serati M, Di Naro E, Casarin J, Marconi N, Pinelli C, and Ghezzi F
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- Adult, Aged, Aged, 80 and over, Female, Humans, Hysterectomy adverse effects, Hysterectomy, Vaginal adverse effects, Hysterectomy, Vaginal methods, Laparoscopy adverse effects, Middle Aged, Cesarean Section, Hysterectomy methods, Laparoscopy methods
- Abstract
Objective: To evaluate surgery-related outcomes of laparoscopic (LH) and vaginal hysterectomy (VH) in patients with a history of previous cesarean section (CS)., Study Design: Data on 289 consecutive patients with a history of CS undergoing VH (n = 49, 17%) and LH (n = 219, 76%) were collected. Basic descriptive statistics, univariate and multivariate analyses were performed to evaluate surgery-related outcomes. A propensity-matched algorithm was applied in order to reduce allocation biases between groups., Results: Patients undergoing LH were more likely to have a history of multiple cesarean sections (44% vs. 18%; p = 0.001). Additionally, uterine weight was greater among patients undergoing LH than VH (median weight: 235 (range, 45-2830) vs. 150 (range, 40-710)g; p < 0.001). Three patients in each group experienced procedural bladder injuries (3/219 (1%) vs. 3/49 (6%); p = 0.07; RR: 1.65; 95%CI: 0.74, 3.68). The rate of grade 3 or worse postoperative complications was balanced between LH and VH (1% vs. 0%; p = 1.00). Patients undergoing LH experienced a shorter length of hospital stay in comparison to patients undergoing VH (1 vs. 2 days; p = 0.02). Considering the overall population, we observed via multivariate analysis that age (OR: 1.003 (95%CI: 1.001, 1.004) per 10-year increase in age; p = 0.002), VH (OR: 17.80 (95%CI: 1.762, 180,378); p = 0.01) and number of cesarean sections ≥ 2 (OR: 27.70 (95%CI: 1.976, 388,285); p = 0.01) increased the risk of developing bladder injuries during hysterectomy., Conclusions: LH is a safe and feasible procedure in patients with previous CS, and it is associated with a low bladder injury rate., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
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- 2015
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6. Nerve-sparing approach reduces sexual dysfunction in patients undergoing laparoscopic radical hysterectomy.
- Author
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Bogani G, Serati M, Nappi R, Cromi A, di Naro E, and Ghezzi F
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- Adult, Aged, Arousal physiology, Dyspareunia prevention & control, Female, Humans, Libido, Middle Aged, Orgasm physiology, Patient Satisfaction, Prospective Studies, Surveys and Questionnaires, Treatment Outcome, Uterine Cervical Neoplasms surgery, Hysterectomy methods, Laparoscopy methods, Organ Sparing Treatments methods, Postoperative Complications prevention & control, Sexual Dysfunction, Physiological prevention & control, Trauma, Nervous System prevention & control
- Abstract
Introduction: Although growing evidence suggests the beneficial effects of a nerve-sparing (NS) approach to surgery in cervical cancer patients, only limited data on NS laparoscopic radical hysterectomy (LRH) are available, and no studies have investigated the effects of NS-LRH on sexual function., Aim: This study aims to determine whether the implementation of NS-LRH impacts on sexual function in cervical cancer patients., Methods: Sexually active cervical cancer patients undergoing type C (class III) LRH between 2004 and 2013 were enrolled in this prospective study., Main Outcome Measures: Preoperative and postoperative sexual function were assessed using a validated questionnaire, the Female Sexual Function Index (FSFI). The FSFI evaluates desire, arousal, lubrication, orgasm, satisfaction, and pain., Results: Forty patients undergoing radical hysterectomy (20 conventional LRH vs. 20 NS-LRH) represented the study group. Baseline characteristics were similar between groups (P > 0.05). No differences in preoperative FSFI scores were recorded (P > 0.05). We observed that both LRH and NS-LRH worsened postoperative FSFI scores (P < 0.001). However, patients undergoing NS-LRH had higher postoperative FSFI scores than patients undergoing LRH (21.3 ± 9.4 vs. 14.2 ± 12.5; P = 0.04). Considering postoperative domain scores, we observed that desire, arousal, orgasm, and pain scores were similar between groups (P > 0.05), while patients undergoing NS-LRH experienced higher lubrication (3.4 ± 2.3 vs. 1.7 ± 2.2; P = 0.02) and satisfaction (4.6 ± 3.9 vs. 2.8 ± 2.2; P = 0.004) scores in comparison with patients undergoing conventional LRH. No between-group differences in survival outcomes were found., Conclusions: Both conventional LRH and NS-LRH impact negatively on patients' sexual function. However, the NS approach impairs sexual function less, minimizing the effects of radical surgery., (© 2014 International Society for Sexual Medicine.)
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- 2014
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7. Predictors of postoperative morbidity after laparoscopic versus open radical hysterectomy plus external beam radiotherapy: a propensity-matched comparison.
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Bogani G, Cromi A, Serati M, Di Naro E, Uccella S, Donadello N, and Ghezzi F
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- Carcinoma, Squamous Cell pathology, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Length of Stay, Lymph Node Excision, Middle Aged, Morbidity, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local etiology, Neoplasm Staging, Prognosis, Propensity Score, Prospective Studies, Uterine Cervical Neoplasms pathology, Carcinoma, Squamous Cell therapy, Hysterectomy adverse effects, Laparoscopy adverse effects, Postoperative Complications diagnosis, Postoperative Complications etiology, Radiotherapy adverse effects, Uterine Cervical Neoplasms therapy
- Abstract
Background: Identification of peri-operative variables predicting postoperative morbidity may improve postoperative patients' care. We aimed to identify patients' characteristics and operative factors predictive of early (≤ 30-day) and late (≤ 6-month) morbidity in cervical cancer patients undergoing surgery plus external beam radiotherapy (EBRT)., Methods: We studied 45 propensity-matched patient pairs (90 patients) undergoing laparoscopic radical hysterectomy (LRH) plus EBRT vs. abdominal radical hysterectomy (RAH) plus EBRT. Basic descriptive, multivariable and artificial neuronal network analyses (ANN) were used to design predicting models influencing outcomes., Results: Baseline characteristics of the study populations were similar. Patients undergoing LRH experienced lower blood loss (200 (range, 10-700) vs. 400 (range, 100-2000) ml; P < 0.001), shorter length of hospital stay (4 (range, 1-10) vs. 8 (range, 5-52) days; P < 0.001) and similar operative time (235 (± 67.3) vs. 258 (± 70.2) min; P = 0.14) than patients undergoing RAH. We observed that, at multivariate analysis, open approach correlated with overall (OR: 1.2; 95%CI: 1.03-1.46), early (OR: 1.14; 95%CI:0.99-1.3) and late (OR: 1.13; 95%CI: 1.001-1.28) postoperative complications., Conclusions: Open approach is the main predictor for developing morbidity among cervical cancer patients undergoing radical hysterectomy followed by adjuvant radiotherapy. Laparoscopic surgery enhances peri-operative surgical results and minimizes the occurrence of late complications., (© 2014 Wiley Periodicals, Inc.)
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- 2014
- Full Text
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8. A prospective case-control study on the impact of neoadjuvant chemotherapy on surgery-related outcomes of laparoscopic radical hysterectomy.
- Author
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Bogani G, Cromi A, Serati M, Di Naro E, Casarin J, Marconi N, Sturla D, Donadello N, and Ghezzi F
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- Adult, Case-Control Studies, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Grading, Neoplasm Staging, Odds Ratio, Prospective Studies, Treatment Outcome, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hysterectomy adverse effects, Laparoscopy adverse effects, Neoadjuvant Therapy, Uterine Cervical Neoplasms drug therapy, Uterine Cervical Neoplasms surgery
- Abstract
Aim: To investigate whether perioperative outcomes of class III/type C laparoscopic radical hysterectomy (LRH) for cervical cancer (CC) are influenced by neoadjuvant chemotherapy (NACT)., Patients and Methods: Data of consecutive patients, affected by locally advanced-stage CC, undergoing NACT plus LRH were matched 1:2 with consecutive patients, affected by early-stage CC who underwent LRH without NACT., Results: Twenty and 40 patients underwent NACT with LRH and LRH aIone, respectively. Demographic characteristics were balanced between groups. Number of lymph nodes yielded, parametrial width and length of vaginal cuff were not influenced by preoperative administration of NACT. Patients undergoing NACT plus LRH experienced slightly higher blood loss (225 vs. 200 ml; p=0.05) than patients in the control group, but had a similar operative time and length of hospital stay. No between-group differences in transfusion and complications rates were observed (p>0.2)., Conclusion: The administration of NACT does not affect the surgery-related outcomes of LRH., (Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
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- 2014
9. Laparoscopic and open abdominal staging for early-stage ovarian cancer: our experience, systematic review, and meta-analysis of comparative studies.
- Author
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Bogani G, Cromi A, Serati M, Di Naro E, Casarin J, Pinelli C, and Ghezzi F
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- Adult, Aged, Female, Humans, Middle Aged, Neoplasm Staging, Operative Time, Ovarian Neoplasms epidemiology, Postoperative Complications epidemiology, Postoperative Complications etiology, Retrospective Studies, Abdomen surgery, Diagnostic Techniques, Surgical, Gynecologic Surgical Procedures methods, Laparoscopy methods, Ovarian Neoplasms pathology
- Abstract
Objectives: The aim of this study was to analyze perioperative and long-term survival outcomes after either laparoscopic or open abdominal staging for apparent early-stage ovarian cancer., Methods: Data of consecutive women with early-stage ovarian cancer undergoing comprehensive laparoscopic staging between 2003 and 2010 were matched with a historical cohort of patients undergoing open surgery. Five-year survival outcomes were analyzed using the Kaplan-Meier method. In addition, a systematic review of the literature and meta-analysis of comparative studies was performed, Results: A total of 35 women undergoing staging via laparoscopy were compared with a cohort of 32 patients undergoing open surgery. Baseline characteristics were similar between groups. Spillage occurred in 6 and 4 patients in laparoscopic and open group, respectively (P = 0.59). Patients undergoing laparoscopy experienced longer operative time (P < 0.001), shorter hospital stay (P = 0.03), and lower postoperative complication rate (3% vs 28%; P = 0.005) than patients undergoing staging via open surgery. The median (range) follow-up period was 64 (37-106) and 100 (61-278) months for case and control, respectively (P < 0.001). Five-year disease-free survival (P = 0.12, log-rank test) and overall survival (P = 0.26, log-rank test) were not influenced by surgical approach. Pooled analyses of the literature results corroborate our results suggesting an improvement of perioperative results in the laparoscopic group in comparison with the open abdominal one. In comparison with open surgery, laparoscopy did not influenced spillage (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.35-1.73) and upstaging rate (OR, 0.7; 95% CI, 0.38-1.27). No between-group differences in survival were observed (OR, 0.5; 95% CI, 0.21-1.21)., Conclusions: Laparoscopy upholds open surgery in long-term oncologic control, reducing morbidity.
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- 2014
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