1. Laminin associated with BMP7 as potential secondary astrocytic glioma fiber differentiation targets.
- Author
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Mao GS, Yan M, Ma ZZ, Sun LZ, and Liu Y
- Subjects
- Adult, Astrocytoma blood, Astrocytoma chemistry, Brain Neoplasms blood, Brain Neoplasms chemistry, Cell Differentiation, Eosinophils, Female, Humans, Male, Middle Aged, Astrocytoma pathology, Bone Morphogenetic Protein 7 analysis, Brain Neoplasms pathology, Laminin analysis
- Abstract
Objective: To investigate the activation of the BMP7 and laminin pathway is associated with glioma cell proliferation and differentiation., Patients and Methods: We enrolled 65 patients with primary operable glioma. Laminin and BMP7 protein expression and its subcellular localization were studied by immunofluorescence., Results: We detected a higher level of BMP7 expression in glioma tissue in patients with a lower grade of glioma who had a lower eosinophil count. Compared to patients with a higher grade of glioma, we observed a lower level of laminin expression in patients with a lower grade of glioma., Conclusions: Our data indicated a potential link between eosinophil counts and the expression levels of laminin and BMP7 in glioma differentiation.
- Published
- 2017