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In this paper the effects of radiation and dissipation in the entropy generation in microtube is evaluated. Governing equations are solved with analytically solution. Fluid flow in the entrance area is laminar and independent of time, and radiation is also a fluid property. Results in this paper extracted with dimensionless numbers Knudsen ( k), Brinkman ( Br) and Prandtl (Pr) that compared with the case without radiation. It is shown that entropy generation decreases with increasing Knudsen number. It can be observed that increasing Br augments the entropy generation. [ABSTRACT FROM AUTHOR]