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Recent earthquakes in New Zealand and Japan showed that pre-shaking histories significantly affected the reliquefaction resistance of soils. In this study, a series of experimental tests was conducted to elucidate the coupled effects of inherent and induced anisotropy on reliquefaction resistance of Toyoura sand, which have not been studied before. Accordingly, loose and dense Toyoura sands were prepared with two different methods: dry deposition and moist tamping. The specimens were sheared cyclically using a hollow cylinder torsional shear apparatus under various cyclic stress ratios up to different residual shear strains (γres) and reconsolidated at different states. The experimental results were assessed from various perspectives, including stress–strain relationships, failure mechanisms, liquefaction/reliquefaction resistance, excess pore water pressure (EPWP) generation and compressibility in conjunction with micromechanical interpretations. It was shown that fabric evolution affects the reliquefaction characteristics of Toyoura sand substantially. Interestingly, a unique correlation exists between EPWP and shear strain accumulation for all tests. An energy-based model was developed to uniquely correlate the dissipated energy with the cyclic resistance based only on residual shear strains; this model shows great promise to develop a unified, energy-based criterion for quantifying the liquefaction/reliquefaction resistance of soils with different fabrics. [ABSTRACT FROM AUTHOR]

Energy consumption has emerged as a hot topic and cutting-edge research theme in the application of electro-osmotic consolidation of low-permeability soils. However, the resistance of circuits in an electro-osmotic consolidation system is complex, whereby electric energy can be converted into various forms of energy. Based on the law of energy conversion, this study proposes a new method for the quantitative evaluation of energy conversion in an electro-osmotic consolidation system. The most important energy created during electro-osmotic consolidation is the molecular migration kinetic energy, which can drive the drainage of water and cations and the consolidation of soil, which is referred to as the effective energy consumption (EEC). The second form of energy is interfacial thermal energy (ITE), which is associated with increasing interfacial resistance. The third form of energy is the soil thermal energy (STE), which is associated with the rising temperature of the system due to the passage of electric current. In the experiments conducted here, the EEC proportion was overestimated by 57–80% in the electro-osmosis process without considering the ITE and STE. The efficiency of electro-osmotic drainage can be considerably enhanced if appropriate measures can be taken to reduce the proportion of ITE and STE. [ABSTRACT FROM AUTHOR]

This paper presents the stress–strain behaviour of three structured clays subjected to a number of stepwise changes in strain rate during shearing in a triaxial apparatus. Undrained compression tests were performed on clay specimens in both undisturbed and reconstituted states. As a result, it has been possible to identify the influence of structure on the rate-dependent response of the clays. Step changes in applied shearing strain rates for all tests resulted in predominately isotache-type behaviour within the range of strains from very small strains to large strains at failure. At very small strains, evidence of a limiting elastic modulus was established for both the stiff sedimentary and artificially cemented soil, which is consistent with published literature on other structured geomaterials. The stress–strain behaviour of all three materials was affected by both the degradation of structure with increasing strain and applied strain rate. The influence of structure on the time-dependent behaviour of the clays is discussed by comparing the response of undisturbed and reconstituted specimens and following normalisation by the equivalent pressure. Results indicate that the rate sensitivity evolves with increasing strains and reaches a maximum at strain levels associated with peak shearing resistance. [ABSTRACT FROM AUTHOR]

In order to improve the understanding on static liquefaction phenomenon, this paper presents an insight into the instability mechanism of a silty sand originating from the Sakarya region (Turkey). Monotonic undrained simple shear tests were performed in either strain-controlled or stress-controlled modes. The interpretation of the experimental results allowed us to draw three interesting conclusions on instability conditions: (1) Hill's stability postulate can be conveniently used to identify the onset of instability for strain-controlled tests, whereas in stress-controlled conditions, an alternative new parameter η* (modified apparent viscosity) was introduced. Depending on the strain rate, η* allows to identify stability conditions more clearly than second-order work; (2) the value of the pore pressure ratio at the onset of instability (ru,is), ranging between 0.30 and 0.50, is linearly linked to the state parameter ψ ; and (3) at the onset of instability, the dependence of both the major and minor principal stress directions (αis and βis) and Lode's angle (θis) on ψ was also observed. These findings are expected to be of some help for a more consistent approach to the constitutive modeling of the static instability mechanism. [ABSTRACT FROM AUTHOR]

Macroprolactinemia is one of the major causes of hyperprolactinemia. The aim of this study was to clarify the origin of macroprolactin (macro-PRL). We examined macro-PRL in the sera of 826 pregnant women and in those of their babies' umbilical cords at delivery. Macro-PRL was evaluated by precipitation with polyethylene glycol (PEG), gel filtration chromatography (GFC), and absorption with protein G (PG). We detected macro-PRL in 16 out of the 826 pregnant women (1.94 %) and in 14 of their babies, which may indicate the possibility of hereditary origin of macro-PRL. However, the macro-PRL ratios of the babies correlated positively with those of their mothers (r=0.72 for GFC, p<0.001 and r=0.77 for PG, p<0.001), suggesting that the immunoglobulin (Ig)G-type anti-PRL autoantibodies might be actively transferred to babies via the placenta and form macro-PRL by binding to their babies' PRL or PRL-IgG complexes may possibly pass through the placenta. There were two cases in which only mothers had macro-PRL, indicating that the mothers had autoantibodies that did not pass through the placenta, such as IgA, PRL bound to the other proteins or PRL aggregates. No cases were found in which only the babies had macro-PRL and their mothers did not, suggesting that macro-PRL might not arise by non-hereditary congenital causes. Macro-PRL in women of reproductive age might be mostly IgG-type anti-PRL autoantibody-bound PRL. The likely origin of macro-PRL in babies is the transplacental transfer of IgG-type anti-PRL autoantibodies or PRL-IgG complexes from the mothers to their babies. [ABSTRACT FROM AUTHOR]

To investigate the effects of different pore water environments on compressive behaviours of the deep-sea soft soil from South China Sea, four kinds of soil samples including natural sample with sea water or deionized water, remolded sample with sea water or deionized water were prepared, respectively. Then, a series of oedometer tests and scanning electron microscopy tests were performed on the above samples to examine their compressive behaviours and microscopic characteristics, respectively. Additionally, the microscopic pore distribution of natural sample with sea water was observed by mercury intrusion porosimetry tests. The effects of different water environments on macroscopic compressive behaviours and microscopic particle characteristics are analyzed. The deionized water environment increases the compressibility and decreases the consolidation coefficient for natural samples after structural breakage and remolding. The microscopic particle characteristics corresponding to the macroscopic compressibility are also qualitatively analyzed. In deionized water environment, soil particles exhibit higher roundness, more orderly and lower surface roughness than that in seawater environment. In this study, the deionized water environment has no obvious effect on the structural yield stress and secondary consolidation coefficients of deep-sea soft soil. [ABSTRACT FROM AUTHOR]

The ring penetrometer is a shallow rotational penetrometer that has been developed to characterise the mechanical behaviour of surficial marine sediments. The strain-rate dependency of soils is crucial to the design of a wide range of offshore geotechnical infrastructure founded in the upper layers of the seabed (e.g. pipelines, cables and shallow foundations). This paper explores the potential application of a ring penetrometer test to measure the strain-rate dependency of the interface friction generated in soft soils at low stresses. Large-deformation numerical models of the test are developed using an elastoplastic constitutive model and a viscoplastic variant with strain softening. Using parameters representative of kaolin clay and a calcareous silt from an offshore location, the numerical analyses demonstrate a clear and measurable influence of both the viscous and strain-softening behaviours on the device–soil interface friction. These simulations were used to design suitable experimental protocols for multi-rate ring penetrometer tests, the results of which yielded a strain-rate dependency of 9–16% and 22–26% per log cycle in the kaolin clay and calcareous silt, respectively, which compare favourably with measurements derived from T-bar twitch experiments. Finally, models are presented that can be applied in the interpretation of varying-rate ring penetrometer test data for application in practice. [ABSTRACT FROM AUTHOR]

MX80 bentonite pellet/powder mixture has been considered as a candidate sealing/filling material in geological high-level radioactive waste disposal. As a single pellet can play an important role in the global hydro-mechanical behaviour of the mixture, the compression behaviour of a single MX80 pellet was investigated by performing uniaxial compression tests on cylinder-shaped pellets at different initial suctions, imposed by the vapour equilibrium technique. Large cracks were observed at suctions ≤ 9 MPa. Results from the compression tests showed that the axial strain εaxial contributed to the contractancy, whereas the lateral strain εlateral contributed to the dilatancy. The uniaxial shear strength σa, max, the crack closure (CC) stress σcc, the crack initiation (CI) stress σci, the crack damage (CD) stress σcd and the Young's modulus E were found to decrease with decreasing suction, providing evidence of the suction effect through softening and cracking. CI was considered as the inflection point of Δεlateral and the onset of dilatancy. Because of the combined effects of suction and wetting-induced cracks, the Poisson's ratios v increased until the suction decreased to 38–25 MPa, and then decreased with further suction decrease. Loading closed the wetting-induced horizontal cracks at suctions ≤ 9 MPa, leading to a drop of εlateral before CC. [ABSTRACT FROM AUTHOR]

This article discusses a gatekeeping intervention implemented in a Belgian hospital to improve the appropriateness of blood urea nitrogen (BUN) testing. The intervention involved a new regulation that restricted reimbursement for BUN analysis in patients with an estimated glomerular filtration rate (eGFR) greater than 30 mL/min/1.73m2. The study found that the intervention led to a significant decrease in the number of BUN tests performed, as well as a change in prescribing behavior among clinicians. The intervention did not have a significant impact on the quality of care or patient safety indicators. Additionally, there was a substantial decrease in total costs associated with BUN testing. The article suggests that gatekeeping interventions could be effective in reducing inappropriate ordering of other tests in the future, but further research is needed to confirm the outcomes. [Extracted from the article]

Cyclic resistance curves, derived through undrained element tests, are central to the study of liquefaction. Their use implies that water drainage is negligible during an earthquake. Nevertheless, a growing body of evidence suggests that this hypothesis is not realistic. In proximity to the interface of a liquefiable layer with an overlying lower permeability layer, upwards water flow can lead to localised, co-seismic pore volume increase. The aim of this paper is to quantify the effects of pore volume increase on cyclic resistance curves. Cyclic triaxial experiments are presented, performed under undrained conditions and under conditions of volumetric expansion. A constant inflow rate is chosen for the sake of simplicity. Results show that even small inflow rates have a detrimental effect on cyclic resistance. A simplified methodology is developed, which can estimate cyclic resistance under constant water inflow rates, by assuming a superposition of isotropic unloading and undrained cyclic shearing. The results presented add to increasing evidence on how current liquefaction susceptibility assessments might not be conservative for layered deposits. In addition, they highlight significant aspects of soil response under partially drained conditions. [ABSTRACT FROM AUTHOR]

Internal erosion by suffusion within a sand–clay mixture may occur as detachment of clay particles, which is induced by a decrease in ionic concentration (IC) along with application of a high hydraulic gradient. Through designed laboratory soil-column experiments, this study investigates the impact of the IC gradient (stepwise or gradual decrease), clay mineralogy, sand particle size and hydraulic gradient on the suffusion of a sand–clay mixture. The observed breakthrough concentration of clay particles revealed the substantial suffusion of a sand–clay mixture caused by a stepwise decrease in the IC for kaolinite and illite, while similar filtrated quantities of bentonite were observed for stepwise and gradual decreases in IC. In addition, the small-grained sand showed a relatively high susceptibility to suffusion by a stepwise decrease in IC, most likely because of the low reattachment of detached clay particles. The mass of filtrated clay particles evaluated from the area of the observed breakthrough curves in this study provides a clear insight into the need to incorporate the IC gradient when assessing the susceptibility to the suffusion of clay-containing soils. [ABSTRACT FROM AUTHOR]

This study explores the estimation of rock properties using sound levels and drilling parameters recorded during quantitative drilling. Utilizing an indoor digital drilling test system and acoustic monitoring device developed by the authors, the research involved setting varied drilling parameters for vertical drilling of various rocks and rock-like materials. The equivalent continuous A-weighted sound pressure levels were measured during the drilling process. Simultaneously, the compressive strength of the drilled rock and rock-like samples was determined in the laboratory. A regression prediction model was developed using drilling rate (V), rotational speed (N), torque (M), propulsive force (F), ground stress magnitude (σ), and equivalent continuous A-weighted sound pressure level (Leq A) as inputs and compressive strength Rc as the output. To enhance prediction accuracy, the model integrates the feature extraction capabilities of traditional random forest (RF) and deep neural network (DNN) methodologies while incorporating a genetic algorithm (GA) for feature selection and parameter optimization. Analysis of the results indicates that the prediction accuracy of the DNN–GA–RF (deep neural network–genetic algorithm–random forest) model, based on sound level and drilling parameters, significantly surpasses traditional methods such as ridge regression, support vector machine, and RF. This finding highlights the potential of the equivalent continuous A-weighted sound pressure level as an effective tool for estimating rock properties during drilling. Furthermore, the model’s integrated learning-based approach to predicting rock strength indicators offers an innovative concept and methodological basis for the nondestructive assessment of rock properties. [ABSTRACT FROM AUTHOR]

Despite its vital importance to the contemporary economy, some drawbacks are mainly associated with waste derived from mining activity. This waste consists of tailings that are hydraulically disposed of in large impoundments, the tailings dams. As the dams are enlarged to accommodate higher amounts of materials, the stress states at which the deposited tailings are submitted change. This may be a concern for the stability of such structures once the geotechnical behavior of this material may be complex and challenging to predict, considering the existing approaches. Thus, the present study concerns the mechanical response of bauxite tailings under a wide span of stresses, ranging from 25 kPa to 4000 kPa. One-dimensional compression tests and isotropically drained and undrained triaxial tests were carried out on intact and remolded samples of the bauxite tailings. The after-shearing grain size distribution was characterized via sedimentation analysis. The results have shown a stress-dependency of the critical state friction angle for the intact material, which may be related to fabric alterations derived from structure deterioration and particle breakage. Overall, this research provides valuable insights into the response of structured and de-structured bauxite tailings, which are helpful for future constitutive modeling of such material. [ABSTRACT FROM AUTHOR]

This article discusses the use of geosynthetic materials (GSM) in hydraulic engineering and civil engineering. On the basis of practical experience, the aspects of conducting specialized laboratory tests to determine GSM quality indicators and to select the most suitable material for solving design problems are described, based on the GSM operation efficiency as part of a structural element of an earth hydraulic engineering structure. [ABSTRACT FROM AUTHOR]

The present study is focused on experimental investigations of mechanical properties of 3D-printed tensegrity-inspired metamaterials. Tensegrity systems have many advantageous features, such as: light weight, high stiffness-to-mass ratio, controllability, inherent attributes of smart structures, and unique mechanical behaviour. They may be applied not only in macro-scale, but they can also be used to create cellular mechanical metamaterials and lattices in various scales. Metamaterials are understood here as human-designed artificial materials, which do not exist in nature, and whose mechanical properties result from the morphology of the inner structure rather than from chemical or phase composition. Experimental studies on tensegrity metamaterials manufactured using 3D printing techniques are hardly present in the literature. This paper presents results of uniaxial compression tests carried out on a number of 3D-printed tensegrity-based modules corresponding to the metamaterial cells, differing in the manufacturing technology, parent material, and size. The following observations were made during the tests: one of the most important parameters that has a direct impact on the results is the elongation at break of the parent material; any inaccuracies at the production stage greatly affect the mechanical behaviour of the structure; it is crucial to ensure a free deformation consistent with the infinitesimal mechanism mode of tensegrity; a post-critical behaviour of the struts was clearly visible in the performed tests.

Introduction. Determination of strength and deformation characteristics of soils composing the soil mass is the key process of calculation and design of structures of all types. High accuracy in determining mechanical characteristics plays a huge role at every stage of project development. Triaxial compression units are one of the most popular and widely used devices for laboratory research, as this type of testing allows you to reproduce the stress-strain state of the soil mass and determine its mechanical characteristics most accurately.Materials and methods. Experimental studies were performed on clay soil specimens (sandy loam, loam, clay) in a triaxial compression device in a consolidated-drained mode in order to study the effect of the coefficient of non-uniformity of expansion of the soil specimen on its mechanical properties.Results. Analyzing the data of experimental studies, it was found that the coefficient of non-uniformity of expansion of specimen b has a significant effect on the obtained values of the mechanical characteristics of clay soil, namely: the values of the angle of internal friction in the medium increased by 5 %; the values of specific adhesion increased by 4.4 % on average. However, it should be noted that despite the increase in the strength characteristics of the tested soil specimens, the exclusion of the coefficient b from the treatment process led to a decrease in the values of the secant deformation modulus at 50 % strength E50 by an average of 4.5 %.Conclusions. The obtained overestimated values of strength characteristics φ, c and underestimated values of deformation characteristics E50 are not critical, however, to increase the accuracy of calculations performed based on the results obtained as a result of in-house processing of laboratory test specimens, the coefficient of uneven expansion b of the specimen should be taken into account.

Background. Determining the cost of laboratory tests is a significant factor in the context of economic analysis and management of clinical diagnostic laboratories. Information about costs allows medical organizations to plan operational activities more efficiently, optimize resource utilization, and exercise control over expenditures. These measures are aimed at improving the financial position and enhancing the operational efficiency of the laboratories.Objective: to review various methods for calculating the cost of laboratory tests.Material and methods. The study included the collection and analysis of publications on calculating cost of laboratory tests, determining their prime cost in PubMed/MEDLINE and Google Scholar databases, as well as in Google and Yandex search engines for similar “cost laboratory test” query. The regulatory documents of the Russian Federation in this area were considered.Results. For calculating the prime cost of laboratory tests such methods as direct costing, regulatory prime costing, total prime costing, activity-based costing (ABC), standard costing, costing for base service, department costing, cost-volume analysis are used. The ABC and standard cost methods provide the most accurate assessment of the impact of various factors.Conclusion. The approaches established by regulatory documents do not contradict each other and represent the implementation of total costing method. At the same time, a medical organization may use other methods for calculating the cost of laboratory tests, depending on the objectives of the analysis, the specifics of the laboratory and the cost accounting method adopted in accounting policy, the management accounting system.

Despite its vital importance to the contemporary economy, some drawbacks are mainly associated with waste derived from mining activity. This waste consists of tailings that are hydraulically disposed of in large impoundments, the tailings dams. As the dams are enlarged to accommodate higher amounts of materials, the stress states at which the deposited tailings are submitted change. This may be a concern for the stability of such structures once the geotechnical behavior of this material may be complex and challenging to predict, considering the existing approaches. Thus, the present study concerns the mechanical response of bauxite tailings under a wide span of stresses, ranging from 25 kPa to 4000 kPa. One-dimensional compression tests and isotropically drained and undrained triaxial tests were carried out on intact and remolded samples of the bauxite tailings. The after-shearing grain size distribution was characterized via sedimentation analysis. The results have shown a stress-dependency of the critical state friction angle for the intact material, which may be related to fabric alterations derived from structure deterioration and particle breakage. Overall, this research provides valuable insights into the response of structured and de-structured bauxite tailings, which are helpful for future constitutive modeling of such material.

Abstract Background Reducing low-value care (LVC) is crucial to improve the quality of patient care while increasing the efficient use of scarce healthcare resources. Recently, strategies to de-implement LVC have been mapped against the Expert Recommendation for Implementing Change (ERIC) compilation of strategies. However, such strategies’ effectiveness across different healthcare practices has not been addressed. This overview of systematic reviews aimed to investigate the effectiveness of de-implementation initiatives and specific ERIC strategy clusters. Methods We searched MEDLINE (Ovid), Epistemonikos.org and Scopus (Elsevier) from 1 January 2010 to 17 April 2023 and used additional search strategies to identify relevant systematic reviews (SRs). Two reviewers independently screened abstracts and full texts against a priori–defined criteria, assessed the SR quality and extracted pre-specified data. We created harvest plots to display the results. Results Of 46 included SRs, 27 focused on drug treatments, such as antibiotics or opioids, twelve on laboratory tests or diagnostic imaging and seven on other healthcare practices. In categorising de-implementation strategies, SR authors applied different techniques: creating self-developed strategies (n = 12), focussing on specific de-implementation strategies (n = 14) and using published taxonomies (n = 12). Overall, 15 SRs provided evidence for the effectiveness of de-implementation interventions to reduce antibiotic and opioid utilisation. Reduced utilisation, albeit inconsistently significant, was documented in the use of antipsychotics and benzodiazepines, as well as in laboratory tests and diagnostic imaging. Strategies within the adapt and tailor to context, develop stakeholder interrelationships, and change infrastructure and workflow ERIC clusters led to a consistent reduction in LVC practices. Conclusion De-implementation initiatives were effective in reducing medication usage, and inconsistent significant reductions were observed for LVC laboratory tests and imaging. Notably, de-implementation clusters such as change infrastructure and workflow and develop stakeholder interrelationships emerged as the most encouraging avenues. Additionally, we provided suggestions to enhance SR quality, emphasising adherence to guidelines for synthesising complex interventions, prioritising appropriateness of care outcomes, documenting the development process of de-implementation initiatives and ensuring consistent reporting of applied de-implementation strategies. Registration OSF Open Science Framework 5ruzw.

Abstract Currently, the treatment of miscellaneous fill foundations, composed of a mixture of domestic garbage, construction solid waste, and natural soil, presents a significant challenge in urban peripheral engineering construction. This paper discusses the application of vibrating rod compaction technology for foundation treatment in Xinjiang. It evaluates the effectiveness of cross-section vibrating rod compaction equipment in reinforcing fine-grained miscellaneous fill foundations. The study analyzes the impact of construction disturbances caused by the insertion of the vibrating rod, monitoring horizontal stresses at various depths. Both laboratory and field tests show significant improvements: soil dry density increased by 8% to 18%, porosity decreased by 10% to 23%, compression modulus increased by 22% to 246%, and compression coefficient decreased by 8% to 70%. Additionally, cohesion (C) and angle of friction (ɸ) saw increases ranging from 7 to 38% and 3% to 25%, respectively. Below a depth of 3 m, cone tip resistance exceeded 10 MPa, and sidewall friction resistance increased to over 100 kPa, surpassing pre-treatment values. The standard penetration test results doubled stroke length compared to pre-treatment, indicating a substantial improvement in foundation bearing capacity. Surface wave tests before and after treatment showed a 15% increase in wave velocity, reflecting a more compact soil structure. The vibrating rod compaction method is innovative, energy-efficient, environmentally friendly, and economically beneficial, holding great potential for future miscellaneous fill treatments.

Abstract Lime is widely used for soft ground treatment, rendering the compressibility of lime-treated soil a crucial factor in deformation analysis in engineering applications. This study investigated the compressibility of three remoulded lime-treated slurries with high water content in Southeast China. Sixty groups of oedometer tests were conducted on lime-treated soils with an initial water content of 1 to 3 times the liquid limit and lime contents between 1 and 3%. The oedometer test results were discussed to examine the remoulded yield stress $${\upsigma }_{y}^{\prime}$$ σ y ′ of lime-treated slurry. Considering the relationships between $${\upsigma }_{y}^{\prime}$$ σ y ′ , the void ratio, lime content, and initial water content were preliminarily discussed and quantitatively established. Research on the normalised compression curve of lime-treated soil revealed that for soil samples containing a lime content of 0–%, the normalised compression curve at $${\upsigma }_{p}^{\prime}$$ σ p ′ > $${\upsigma }_{y}^{\prime}$$ σ y ′ can be represented by a unique line. Furthermore, the log(1 + e) − log $${\sigma }_{\text{v}}^{\prime}$$ σ v ′ compression curve of lime-treated slurry at pre-yield state is analysed, and a prediction method for the modified compression index is proposed.

Background: Reducing low-value care (LVC) is crucial to improve the quality of patient care while increasing the efficient use of scarce healthcare resources. Recently, strategies to de-implement LVC have been mapped against the Expert Recommendation for Implementing Change (ERIC) compilation of strategies. However, such strategies' effectiveness across different healthcare practices has not been addressed. This overview of systematic reviews aimed to investigate the effectiveness of de-implementation initiatives and specific ERIC strategy clusters. Methods: We searched MEDLINE (Ovid), Epistemonikos.org and Scopus (Elsevier) from 1 January 2010 to 17 April 2023 and used additional search strategies to identify relevant systematic reviews (SRs). Two reviewers independently screened abstracts and full texts against a priori–defined criteria, assessed the SR quality and extracted pre-specified data. We created harvest plots to display the results. Results: Of 46 included SRs, 27 focused on drug treatments, such as antibiotics or opioids, twelve on laboratory tests or diagnostic imaging and seven on other healthcare practices. In categorising de-implementation strategies, SR authors applied different techniques: creating self-developed strategies (n = 12), focussing on specific de-implementation strategies (n = 14) and using published taxonomies (n = 12). Overall, 15 SRs provided evidence for the effectiveness of de-implementation interventions to reduce antibiotic and opioid utilisation. Reduced utilisation, albeit inconsistently significant, was documented in the use of antipsychotics and benzodiazepines, as well as in laboratory tests and diagnostic imaging. Strategies within the adapt and tailor to context, develop stakeholder interrelationships, and change infrastructure and workflow ERIC clusters led to a consistent reduction in LVC practices. Conclusion: De-implementation initiatives were effective in reducing medication usage, and inconsistent significant reductions were observed for LVC laboratory tests and imaging. Notably, de-implementation clusters such as change infrastructure and workflow and develop stakeholder interrelationships emerged as the most encouraging avenues. Additionally, we provided suggestions to enhance SR quality, emphasising adherence to guidelines for synthesising complex interventions, prioritising appropriateness of care outcomes, documenting the development process of de-implementation initiatives and ensuring consistent reporting of applied de-implementation strategies. Registration: OSF Open Science Framework 5ruzw. [ABSTRACT FROM AUTHOR]

The formation conditions of maximum- and minimum-wave jumps were experimentally investigated. A total of 110 wave-type jump experiments were carried out for several discharges, supercritical upstream and subcritical downstream water depths and drop heights. The experimental results revealed that the influential parameters on wave-type jumps are the upstream Froude number and the relative drop height. As the classical hydraulic jump equation is not sufficient to define conjugate depths of wave-type flow, empirical equations were developed for defining the conjugate depths of maximum-wave jumps and minimum-wave jumps (for which insufficient experimental data are available in the literature). The agreement between calculated and measured conjugate depths was good. It was also found that the value of the lower limit for the upstream Froude number is not constant for the formation of a maximum-wave jump – it depends on the relative drop height. Furthermore, the experimental results showed that the energy-dissipation ratios of maximum- and minimum-wave jumps are equal to or larger than those of classical hydraulic jumps. For this reason, wave-type jumps may be preferred at stilling basins with drops along with A-jumps. [ABSTRACT FROM AUTHOR]

Two series of experiments were carried out to examine pressurised bentonite slurry infiltration into saturated sand columns. Three types of sand were examined, and water–bentonite and water–bentonite–sand slurries were used in series 1 and 2, respectively. Series 1 investigated the effect of sand particle size and series 2 examined the effect of the fine-sand particle content in the slurry. Scanning electron microscopy (SEM) imaging was used to observe the morphological features of the dry slurry-infiltrated sand samples. A solution for the infiltration distance during mud spurt for water–bentonite–sand slurry infiltration was verified using the data from series 2. The infiltration test results showed that the hydraulic conductivity of the slurry-infiltrated coarse sand for slurry in series 2 was lower than that in series 1. Visual observations and the SEM images showed that sand particles were bound to a bentonite film, indicating that, during infiltration, the channels for fluid flow among the sand particles are blocked by the bentonite particles adhered to the sand particles. The solution for the infiltration distance during mud spurt for water–bentonite–sand slurry infiltration showed good agreement with the experimental results. [ABSTRACT FROM AUTHOR]

Chemical grouting is a technique where solution-based binders are used to improve both mechanical and hydraulic properties of the soil or rocks. The following research study shows an extensive laboratory programme where a polyurethane (PU) and an acrylate (AC) were grouted in a tertiary sand under different water contents and relative density, with different gelling time and grouting conditions. Unconfined compressive strength, splitting tests, triaxial tests and creep tests on the grouted materials were conducted. A statistical interpretation considering the kernel probability density function was performed in order to understand the interdependency of the changing parameters. In general, PU-consolidated samples provide higher mechanical properties with respect to ACs; however, the effects and the dependency on the geotechnical base parameters are different. [ABSTRACT FROM AUTHOR]

Vertical drains are used widely to accelerate the consolidation of soft clay deposits when preloading is used as a ground improvement technique. One of the essential input parameters required in Barron's theory is the coefficient of horizontal consolidation, ch. The values of ch can be determined by the radial consolidation test, using either a central sand drain or a porous plastic peripheral drain. This paper presents the laboratory tests carried out to understand the reason for the difference in values of ch determined from inward and outward radial flow consolidations tests. A 150 mm wide instrumented consolidation cell was used to carry out the inward or outward radial consolidation tests. The total stress measurements during consolidation showed non-uniform stress distribution in clay with higher effective stress values close to the drainage boundary. This stiffening of the clay close to the drain retards the consolidation rate resulting in reduced values of ch. As a result, the ch values determined by radially outward consolidation tests with a larger drainage boundary area are lower to those obtained by inward radial flow tests. The pore water pressure measurements showed significantly higher undissipated pore water pressure away from the drainage boundary for the outward flow tests. [ABSTRACT FROM AUTHOR]

A team comprising nursing, medical staff, and administrative leaders at an urban academic orthopedic hospital in the northeastern United States sought to revise a preoperative laboratory testing protocol based on evidence and practice guidelines. The goal was to decrease unnecessary tests by 20% without negatively affecting patient outcomes. After adding the revised protocol to the electronic health record, audits revealed that the target goal was not met and additional strategies were implemented, including educational webinars for surgeon office personnel who ordered tests, additional webinars for advanced practice professionals, and the creation of scorecards to track surgeons' progress. Overall, a downward trend in the ordering of unnecessary laboratory tests for patients without identified risks was observed, but a 20% reduction was not achieved. Surgical complications during the project were not associated with laboratory tests. Clinicians continue to use the revised preoperative laboratory testing protocol at the facility. [ABSTRACT FROM AUTHOR]

Currently, the treatment of miscellaneous fill foundations, composed of a mixture of domestic garbage, construction solid waste, and natural soil, presents a significant challenge in urban peripheral engineering construction. This paper discusses the application of vibrating rod compaction technology for foundation treatment in Xinjiang. It evaluates the effectiveness of cross-section vibrating rod compaction equipment in reinforcing fine-grained miscellaneous fill foundations. The study analyzes the impact of construction disturbances caused by the insertion of the vibrating rod, monitoring horizontal stresses at various depths. Both laboratory and field tests show significant improvements: soil dry density increased by 8% to 18%, porosity decreased by 10% to 23%, compression modulus increased by 22% to 246%, and compression coefficient decreased by 8% to 70%. Additionally, cohesion (C) and angle of friction (ɸ) saw increases ranging from 7 to 38% and 3% to 25%, respectively. Below a depth of 3 m, cone tip resistance exceeded 10 MPa, and sidewall friction resistance increased to over 100 kPa, surpassing pre-treatment values. The standard penetration test results doubled stroke length compared to pre-treatment, indicating a substantial improvement in foundation bearing capacity. Surface wave tests before and after treatment showed a 15% increase in wave velocity, reflecting a more compact soil structure. The vibrating rod compaction method is innovative, energy-efficient, environmentally friendly, and economically beneficial, holding great potential for future miscellaneous fill treatments. [ABSTRACT FROM AUTHOR]

The epidemiological and clinical characteristics of acute poisoning with liquid laundry detergent capsules have been comprehensively reported. However, studies of laboratory test results in these exposures are uncommon. This study analyzed the impact of the ingestion of liquid laundry detergent capsules on admission laboratory tests in paediatric patients. This retrospective study was conducted in the clinical toxicology unit of a paediatric poison centre between 2015 and 2021. Paediatric patients (less than 18 years of age) who ingested liquid laundry detergent capsules were included. The relationship between the European Association of Poisons Centers and Clinical Toxicologists/European Commission/International Programme on Chemical Safety Poisoning Severity Score and admission laboratory test results was assessed using Fisher's exact test or analysis of variance. A total of 156 patients were included in the study. A considerable proportion of patients presented with leucocytosis, acidosis, hyperlactataemia or base deficit. The median values of white blood cell count (P = 0.042), pH (P = 0.022), and base excess (P = 0.013) were significantly different among the Poisoning Severity Score groups. Hyperlactataemia was strongly associated with the Poisoning Severity Score (P = 0.003). Leucocytosis is a non-specific marker of severity following ingestion of liquid laundry detergent capsules. The incidence of metabolic acidosis and hyperlactataemia was higher in this study than in previous reports, but these metabolic features were not related to the severity of exposure. The exact mechanisms of toxicity are not yet known, but the high concentration of non-ionic and anionic surfactants, as well as propylene glycol and ethanol, in the capsule are likely contributing factors. Pediatric patients who ingest liquid laundry detergent capsules may develop leucocytosis, metabolic acidosis, hyperlactataemia, and a base deficit. [ABSTRACT FROM AUTHOR]

Kidney stone disease is a widespread urological disorder affecting millions globally. Timely diagnosis is crucial to avoid severe complications. Traditionally, renal stones are detected using computed tomography (CT), which, despite its effectiveness, is costly, resource-intensive, exposes patients to unnecessary radiation, and often results in delays due to radiology report wait times. This study presents a novel approach leveraging machine learning to detect renal stones early using routine laboratory test results. We utilized an extensive dataset comprising 2156 patient records from a Saudi Arabian hospital, featuring 15 attributes with challenges such as missing data and class imbalance. We evaluated various machine learning algorithms and imputation methods, including single and multiple imputations, as well as oversampling and undersampling techniques. Our results demonstrate that ensemble tree-based classifiers, specifically random forest (RF) and extra tree classifiers (ETree), outperform others with remarkable accuracy rates of 99%, recall rates of 98%, and F1 scores of 99% for RF, and 92% for ETree. This study underscores the potential of non-invasive, cost-effective laboratory tests for renal stone detection, promoting prompt and improved medical support. [ABSTRACT FROM AUTHOR]

The softening effect has been widely accepted as the fundamental mechanical property of the granular materials, which underlies some specific phenomena such as fluidization during vibration. In this paper, a series of resonance column experiments are performed to observe the modulus softening of granular materials. A statistical softening model is subsequently proposed and its applicability is verified through a quantitative analysis of the variation of the normalized modulus by changing the external confining pressure. The average potential energy in grain contact has been found to be a power-law scaling with grain size. An evolution model is further implemented to account for the experimental findings on the evolution of modulus of the granular system subjected to different confining pressures. The modulus evolution, including softening and recovery, can be captured by the unified evolution model. [ABSTRACT FROM AUTHOR]

Refractory materials containing calcium aluminate cement (CAC) are commonly used in the metallurgical and petrochemical industries due to their exceptional mechanical resistance, even at temperatures exceeding 1000 °C, and do not require additional reinforcement. This study seeks to advance this practice by developing ultra-high-performance structures that offer building protection against fire and explosions. Such structures require bar reinforcement to withstand accidental tension stresses, and the bond performance becomes crucial. However, the compressive strength of these materials may not correlate with their bond resistance under high-temperature conditions. This study investigates the bond behavior of ribbed stainless austenitic steel bars in refractory materials typical for structural projects. The analysis considers three chamotte-based compositions, i.e., a conventional castable (CC) with 25 wt% CAC, a medium-cement castable (MCC) with 12 wt% CAC, a low-cement castable (LCC), and a low-cement bauxite-based castable (LCB); the LCC and LCB castables contain 7 wt% CAC. The first three refractory compositions were designed to achieve a cold compressive strength (CCS) of 100 MPa, while the LCB mix proportions were set to reach a CCS of 150 MPa. Mechanical and pull-out tests were conducted after treatment at 400 °C, 600 °C, 800 °C, and 1000 °C; reference specimens were not subjected to additional temperature treatment. This study used X-ray fluorescence (XRF), X-ray diffraction (XRD), and scanning electron microscopy (SEM) methods to capture the material alterations. The test results indicated that the bonding resistance, expressed in terms of the pull-out deformation energy, did not directly correlate with the compressive strength, supporting the research hypothesis. [ABSTRACT FROM AUTHOR]

The soil is in a small strain state in most areas during the shield construction process, which is different from the soil properties of the commonly used intrinsic model. Therefore, in order to study the static-dynamic behaviour and engineering applicability of typical silty clay in the area of Jinan Jinluo Road Tunnel passing under Yellow River, the basic physical property parameters of silty clay and tangential stiffness Eref oed, natural stiffness Eref 50, unloading / reloading reference stiffness Eref ur were determined by laboratory soil tests, confined consolidation tests, standard triaxial consolidation tests, and dynamic triaxial tests. Then the obtained parameters were applied in the settlement analysis of the north bank embankment under the tunnel project of Jinan Tunnel through Yellow River. The obtained parameters were applied to the settlement analysis of the Jinan Jinluo Road Tunnel Project passing under the north bank embankment, and the accuracy of the HSS principal model in the deformation analysis of the area was verified by comparing the simulation results of the hardening soil model with small strain stiffness( HSS) model and the Mohr-Coulomb( M-C) model with the field measurement results. The results show that when the perimeter pressure is certain, the vertical strain of the silty clay specimens in this area is dominated by plastic strain, and with the increase of dynamic stress, the longer time is needed for the soil to reach the stability. When the cyclic load is certain, increasing the perimeter pressure of the soil could improve the stability of the soil. The deformation of the ground layer of the Jinan Jinluo Road Tunnel through the Yellow River Tunnel Project passing under the embankment, which is simulated based on the parameters of the HSS model obtained from laboratory experiments, is in good agreement with the measured values in the field. The research results could enrich the study of the stratigraphic parameters of silty clay in Jinan Yellow River area, and provide reference for the selection of the soil model and stratigraphic parameters for the numerical simulation and analysis of geotechnical engineering in this area. [ABSTRACT FROM AUTHOR]

Lime is widely used for soft ground treatment, rendering the compressibility of lime-treated soil a crucial factor in deformation analysis in engineering applications. This study investigated the compressibility of three remoulded lime-treated slurries with high water content in Southeast China. Sixty groups of oedometer tests were conducted on lime-treated soils with an initial water content of 1 to 3 times the liquid limit and lime contents between 1 and 3%. The oedometer test results were discussed to examine the remoulded yield stress σ y ′ of lime-treated slurry. Considering the relationships between σ y ′ , the void ratio, lime content, and initial water content were preliminarily discussed and quantitatively established. Research on the normalised compression curve of lime-treated soil revealed that for soil samples containing a lime content of 0–%, the normalised compression curve at σ p ′ > σ y ′ can be represented by a unique line. Furthermore, the log(1 + e) − log σ v ′ compression curve of lime-treated slurry at pre-yield state is analysed, and a prediction method for the modified compression index is proposed. [ABSTRACT FROM AUTHOR]

Visco‐hypoplastic material model for tertiary soils in Frankfurt am Main The subsoil conditions in the city centre of Frankfurt am Main are characterized by tertiary over‐consolidated clays and clayey marls with embedded limestone banks and sand layers, whose thickness varies considerably depending on the location. In a research project, the time‐dependent material response of these tertiary clays, which significantly influence the deformation behaviour of buildings, was investigated with a comprehensive laboratory test program and a set of parameters for the visco‐hypoplastic AVISA model was determined. This article summarizes the findings obtained for the tertiary Frankfurt clays. In addition, a concept is proposed with which the system permeability and the system stiffness of the heterogeneous tertiary layers taking into account embedded limestone banks and sand layers can be realistically modelled in 3D coupled pore pressure‐displacement analyses with the finite element method. [ABSTRACT FROM AUTHOR]

This paper presents measurements of total pressures and pore pressures in the mixing chamber, the pore pressures in the soil in front of an earth pressure balance (EPB) at the Botlek Rail tunnel, as well as laboratory tests on foam infiltration behavior from foam–sand mixture to saturated sand. It shows that the plastering effect at the tunnel face is less effective for an EPB shield than for a slurry shield, as the pressure fluctuations are greater in the mixing chamber for an EPB shield, suggesting a higher water leakage at the tunnel face. The difference in the development of excess pore pressure at two different locations of the EPB shield suggests the influence of the soil permeability. Foam infiltration at the tunnel face can result in a low permeable layer that restricts the ground water flow. Results from laboratory tests suggest that foam infiltration will be influenced by foam injection ratio and soil permeability. As the foam infiltration length is only limited, no low permeable layer can be formed during drilling for fine sand conditions. While a larger foam infiltration length can be expected for medium sand condition. Field measurements on the development of pore pressures in the soils at the two different locations show agreement with the conclusions from laboratory tests. [ABSTRACT FROM AUTHOR]

Patients treated for systemic urinary tract infections commonly have nonspecific presentations, and the specificity of the results of the urinalysis and urine cultures is low. In the following narrative review, we will describe the widespread misuse of urine testing, and consider how to limit testing, the disutility of urine cultures, and the use of antibiotics in hospitalized adult patients. Automated dipstick testing is more precise and sensitive than the microscopic urinalysis which will result in false negative test results if ordered to confirm a positive dipstick test result. There is evidence that canceling urine cultures if the dipstick is negative (negative leukocyte esterase, and nitrite) is safe and helps prevent the overuse of urine cultures. Because of the side effects of introducing a urine catheter, for patients who cannot provide a urine sample, empiric antibiotic treatment should be considered as an alternative to culturing the urine if a trial of withholding antibiotic therapy is not an option. Treatment options that will decrease both narrower and wider spectrum antibiotic use include a period of watching and waiting before antibiotic therapy and empiric treatment with antibiotics that have resistance rates > 10%. Further studies are warranted to show the option that maximizes patient comfort and safety. [ABSTRACT FROM AUTHOR]

The objective of this study was to explore the higher-order turbulence statistics of flow and turbulent length scales around a complex pier (CP) and compare the results with those for a simple pier (SP). The velocity data were recorded in a laboratory flume using particle image velocimetry (PIV). The PIV data were analysed to estimate the velocity fluctuations of third order, turbulence production and dissipation rates, turbulent length scales and the contributions of burst–sweep events to the total Reynolds shear stress around the piers mounted on a rigid flat surface. The skewness and advection coefficients indicated a more asymmetric distribution of velocity fluctuations for the SP than for the CP. Ejection and sweep events illustrated the dominance of similar strengths for an extended period, downstream of the piers. The upstream turbulent kinetic energy production was similar for both piers, while the upstream dissipation rate was higher for the CP. The length scales were greater at the upstream for the case of the SP while, downstream, they were greater for the CP. The findings of this work demonstrate the importance of a pile cap in restricting downward-moving flow by showing a lower magnitude of scour-inducing turbulence parameters for the CP as compared with the SP. [ABSTRACT FROM AUTHOR]

Anibi S, Ellouze S, Zairi M. 2024. Reservoir siltation and sediment characterization for reuse as construction material in a semi-arid area. Lake Reserv Manage. 40:159–176. In this study, we investigated the siltation rate, evolution, and spatial distribution of sediments within the Siliana Dam reservoir, north-west Tunisia. We analyzed the geotechnical, chemical, mineralogical, and trace metal content properties of sediment samples collected from the reservoir. Additionally, we examined the potential valorization of reservoir sediments in road construction and the effects of hydrated lime treatment on their bearing characteristics. The Siliana dam reservoir is currently 50% silted up, and the sedimentation rate is approximately 1.52% per year. The sediments are mainly fine-grained, low organic with medium to high plasticity and high content of calcium carbonate. The sediments consist of calcite and quartz, with minor amounts of dolomite, hematite, and phyllosilicate minerals. Chromium, zinc, and copper contents in the sediments exceed environmental standards. The lime treatment improved the materials bearing capacity. Adding lime (5% by weight) resulted in an immediate bearing ratio of 26%, a higher ratio compared to the raw sediments. The study of the spatial and temporal evolution of sediment accumulation provides information to develop strategies for mitigating the accumulation of sediments. The sediment characterization evaluated the suitability of sediments to be used as construction materials, offering potential cost savings and contributing to informed decision-making for reservoir management. [ABSTRACT FROM AUTHOR]

Abstract This paper aims to estimate the permeability of concrete by replacing the laboratory tests with robust machine learning (ML)-based models. For this purpose, the potential of twelve well-known ML techniques was investigated in estimating the water penetration depth (WPD) of nano natural pozzolana (NNP)-reinforced concrete based on 840 data points. The preparation of concrete specimens was based on the different combinations of NNP content, water-to-cement (W/C) ratio, median particle size (MPS) of NNP, and curing time (CT). Comparing the results estimated by the ML models with the laboratory results revealed that the hist-gradient boosting regressor (HGBR) and K-nearest neighbors (KNN) algorithms were the most and least robust models to estimate the WPD of NNP-reinforced concrete, respectively. Both laboratory and ML results showed that the WPD of NNP-reinforced concrete decreased with the increase of the NNP content from 1 to 4%, the decrease of the W/C ratio and the MPS, and the increase of the CT. To further aid in the estimation of concrete’s WPD for engineering challenges, a graphical user interface for the ML-based models was developed. Proposing such a model may be effectively employed in the management of concrete quality.