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Results of an investigation of the wound-healing activity and toxicity parameters of a gel based on guanidine-containing pectin derivatives are presented. It is established that the developed 0.5% pectin guanidine gel exhibits a high rate of wound healing that reaches 82% on the 7th day of treatment. The gel belongs to class VI of relatively harmless compounds, with an LD50 value of >3000 mg/kg for cutaneous application to rats. There were no signs of skin irritation in the form of redness, peeling, or changes in the fur cover in local shaven and adjacent regions in rats. Chronic toxicity studies showed that daily skin application of the pectin guanidine gel for 30 d did not produce any toxic effects on the quantitative composition and morphology of peripheral blood in experimental animals. [ABSTRACT FROM AUTHOR]

Objective To report the design and benefits of a rigid polyethylene cover 'shell' for the protection of dorsal torso wounds and tube fixation in pigs. Methods Open C-shaped polyethylene shells were designed to protect wounds and dressings on the dorsum of pigs used in research into negative pressure dressing-assisted wound healing. The shells were designed to resist trauma and contamination, to be comfortable and expansible, and to facilitate tube fixation and management. Strap fixation was optimised during experimentation. Efficacy was assessed by direct observation of dressing and wound protection, tube integrity and by macroscopic and microscopic assessments of wound healing. Results The shells effectively protected the wounds against blunt and sharp trauma, were simple to remove and reapply, were well tolerated and allowed for growth of the pigs. Circumferential neck straps attached by lateral straps to the shells proved critical. There was no wound infection or inflammation underlying the shells. Porting tubing via mid-dorsal holes in the shells and affixing the tubing just cranial to these holes prevented tube damage and traction, permitted tube management from outside the cages and allowed the pigs to move freely without becoming entangled. Conclusion These shells effectively protected dorsal skin wounds and dressings, prevented tube damage and facilitated tube management in pigs. Similar systems may be useful for other production animals for wound management and for tube management with negative pressure wound healing, drain tubes or the delivery of nutrition, fluids or medications. [ABSTRACT FROM AUTHOR]