Search

Your search keyword '"Xu, Ming-Jun"' showing total 3 results
Start Over Author "Xu, Ming-Jun" Topic labor, obstetric
3 results on '"Xu, Ming-Jun"'

1. Neuraxial labor analgesia is associated with a reduced risk of postpartum depression: A multicenter prospective cohort study with propensity score matching.

Author

Deng CM, Ding T, Li S, Lei B, Xu MJ, Wang L, Xu SC, Yang HX, Sun XY, Li XY, Ma D, and Wang DX

Subjects
Female, Humans, Pregnancy, Propensity Score, Prospective Studies, Analgesia, Epidural adverse effects, Depression, Postpartum epidemiology, Labor, Obstetric
Abstract

Background: Depression is a common and serious complication in new mothers. We investigated the hypothesis that neuraxial labor analgesia is associated with a decreased risk of postpartum depression., Methods: In this multicenter prospective cohort study with propensity score matching, 599 nulliparous women with single term cephalic pregnancy who planned vaginal delivery were enrolled and self-selected neuraxial analgesia or not. The primary outcome was 6-week postpartum depression assessed with the Chinese version Edinburgh Postnatal Depression Scale; a score of ≥10 was set as the threshold of postpartum depression. Logistic regression models were established to assess the association between neuraxial labor analgesia and postpartum depression., Results: Of the 577 parturients who completed the study, 417 (72.3%) received neuraxial analgesia and 160 (27.7%) did not. After propensity score matching, 433 parturients were included in the analysis; of whom, 279 (64.4%) received neuraxial analgesia and 154 (35.6%) did not. The incidence of postpartum depression was lower in parturients with neuraxial analgesia than in those without (14.9% [62/417] vs. 23.8% [38/160], P=0.012 before matching; 13.3% [37/279] vs. 23.4% [36/154], P=0.007 after matching). After adjustment for confounding factors, neuraxial analgesia was associated with decreased odds of postpartum depression (odds ratio [OR] 0.50, 95% CI 0.28-0.88, P=0.015 before matching; OR 0.40, 95% CI 0.21-0.77, P=0.006 after matching)., Limitations: As an observational study, unidentified confounders might influence the results., Conclusions: In nulliparae with single term cephalic pregnancy preparing to give vaginal delivery neuraxial analgesia during labor was associated with a decreased risk of 6-week postpartum depression., (Copyright © 2020. Published by Elsevier B.V.)

Published
2021
Full Text
View/download PDF

3. Neuraxial labour analgesia is associated with a reduced risk of maternal depression at 2 years after childbirth

Author

Liu, Zhi-Hua, He, Shu-Ting, Deng, Chun-Mei, Ding, Ting, Xu, Ming-Jun, Wang, Lei, Li, Xue-Ying, and Wang, Dong-Xin

Subjects
Adult, Labor, Obstetric, Postpartum Period, Parturition, Delivery, Obstetric, Severity of Illness Index, Analgesia, Epidural, Depression, Postpartum, Young Adult, Pregnancy, Obstetric Anaesthesia, Surveys and Questionnaires, Multivariate Analysis, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Odds Ratio, Analgesia, Obstetrical, Humans, Pain Management, Female, Longitudinal Studies, Prospective Studies, Follow-Up Studies
Abstract

Supplemental Digital Content is available in the text, BACKGROUND Severe labour pain is an important risk factor of postpartum depression, and early depression is associated with an increased risk of long-term depression; whereas the use of epidural analgesia during labour decreases the risk of postpartum depression. OBJECTIVE To investigate whether neuraxial labour analgesia was associated with a decreased risk of 2-year depression. DESIGN This was a multicentre, prospective, longitudinal study. SETTING The study was performed in Peking University First Hospital, Beijing Obstetrics and Gynecology Hospital and Haidian Maternal and Child Health Hospital in Beijing, China, between 1 August 2014 and 25 April 2017. PATIENTS Five hundred ninety-nine nulliparous women with single-term cephalic pregnancy preparing for vaginal delivery were enrolled. MAIN OUTCOME MEASURE Depressive symptoms were screened with the Edinburgh Postnatal Depression Scale at delivery-room admission, 6-week postpartum and 2 years after childbirth. A score of 10 or higher was used as the threshold of depression. The primary endpoint was the presence of depression at 2 years after childbirth. The association between the use of neuraxial labour analgesia and the development of 2-year depression was analysed with a multivariable logistic regression model. RESULTS Five hundred and eight parturients completed 2-year follow-up. Of these, 368 (72.4%) received neuraxial analgesia during labour and 140 (27.6%) did not. The percentage with 2-year depression was lower in those with neuraxial labour analgesia than in those without (7.3 [27/368] vs. 13.6% [19/140]; P = 0.029). After correction for confounding factors, the use of neuraxial analgesia during labour was associated with a significantly decreased risk of 2-year depression (odds ratio 0.455, 95% confidence interval 0.230 to 0.898; P = 0.023). CONCLUSION For nulliparous women with single-term cephalic pregnancy planning for vaginal delivery, the use of neuraxial analgesia during labour was associated with a reduced risk of maternal depression at 2 years after childbirth. TRIAL REGISTRATION www.chictr.org.cn: ChiCTR-OCH-14004888 and ClinicalTrials.gov: NCT02823418.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results