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ELIZABETH VARGAS (ABC NEWS) (Voiceover) In 2016, a crime wave swept across American television, a tsunami of true crime. From the silver screen to the TV screen to even smaller screens, viewers were obsessed. [ABSTRACT FROM PUBLISHER]

DAVID MUIR (ABC NEWS) (Off-camera) And next here to the Amanda Knox case tonight. And from Italy this evening, the judge who presided over the trial this week that found her guilty now talking about what he called his suffering over the decision. Will Amanda Knox now be sent back to Italy? Here's ABC's Elizabeth Vargas. [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) Now picking up with Amanda's triumphant return to American soil and that fresh air of Seattle. She was free, for now. But the traumatic memories of Italy and her time in jail were never far away and nor was the weight of wondering if she could be sent back to serve a new sentence. With this week's verdict, those fears are now front and center. [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) Good evening. Guilty again. That is the stunning reversal from an Italian judge who said just today that he suffered over the latest Amanda Knox verdict. As you know, it's a verdict that keeps changing in the eerie whodunit that's been called Italy's trial of the century. I've covered this case for six years now as Amanda Knox spent 1400 nights in prison. And now speaking only to ABC News, she says she'll have to be taken back kicking and screaming. [ABSTRACT FROM PUBLISHER]

JUJU CHANG (ABC NEWS) (Off-camera) Good evening and thanks for joining us. Tonight, Seattle college student Amanda Knox speaking out for the first time since that bombshell guilty verdict, a reversal that once again puts her freedom in jeopardy. For the past 6 1/2 years, her fate has been in the hands of the Italian justice system. Guilty, not guilty, and now guilty again. But tonight, she comes out strong, saying she's not about to give up her fight. And in her first and only interview since the surprising new verdict, here's ABC's Elizabeth Vargas. [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) A lot of people in Steubenville agree with her. It's deeply divided that town there. It's very, very difficult story. All right. Let's have a move on to another difficult story, the latest on the Amanda Knox case. [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) All right, thanks so much. It's okay. We're sitting here chatting on the couch. Now to Amanda Knox who after nearly six years is telling her side of the story that made her a household name. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) Okay, Robin. Thanks. Now to that surprising new twist in the Amanda Knox story. [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) This has been a year of gripping courtroom dramas, from the manslaughter conviction of Michael Jackson's doctor to the murder acquittals of two, young American women. The verdict on 2011 is in. It's one of the biggest years for blockbuster trials we have ever seen. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Voiceover) Pretty stunning news this morning in the Amanda Knox case, two months after she returned home from four years in an Italian prison. Judges crushed the prosecutor's original case, saying there was never any solid evidence against Amanda. "20/20" anchor Elizabeth Vargas has been reporting on this case from the beginning. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) Now, George, to new details on Amanda Knox. Her former boyfriend, also acquitted in the death of Knox's roommate, speaking out for the first time since their release in early October. Raffaele Sollecito says he wants to set the record straight on the case and on the rumors about his relationship with Amanda. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Voiceover) We're gonna get right to the latest on Amanda Knox, though, trying to catch up on everything she's missed during her four years behind bars. "20/20" co-anchor Elizabeth Vargas has covered Amanda's story from the beginning and is back here now with, well, I can't believe it was just Monday... [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) And ABC's Neal Karlinsky was right there for the emotional homecoming, and has more on Amanda's first night at home in Seattle. [ABSTRACT FROM PUBLISHER]

DAVID MUIR (ABC NEWS) (Off-camera) We have a team on this case tonight, beginning with "20/20" co-anchor Elizabeth Vargas who has covered this case from the start, and she's in Perugia tonight. Elizabeth? [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) There is so much drama in this case, and "20/20" co-anchor, Elizabeth Vargas, has covered it from the very start. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) We certainly do, because she is headed home to Seattle right now. And we're gonna show you pictures again of her family checking in at Rome's airport earlier this morning. And we're gonna go back to "20/20" co-anchor, Elizabeth Vargas, who is there in Italy with the latest on Amanda Knox's release. Elizabeth. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) And let's get right to Elizabeth, who has covered this case from the start. Good morning, Elizabeth. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) All that is coming up, plus some breaking news as well about ABC News and about "GMA." This is gonna change the way you look at us, the way you get your news, it's big news and we can't wait to share all that. But first, let's go back to "20/20" co-anchor Elizabeth Vargas, she's in Perugia with the very latest on Amanda Knox. Hello, Elizabeth. [ABSTRACT FROM PUBLISHER]

DAN HARRIS (ABC NEWS) (Off-camera) Thank you, a fascinating debate. And that wraps up our coverage of the terror strike for this morning. Now to the trial of Amanda Knox, which is very quickly approaching its wrenching, riveting climax. Monday is the key day. That is when Amanda herself will make a final plea for freedom. In the courtroom on Friday, lawyers for both sides were making their final arguments. And - "20/20" co-anchor Elizabeth Vargas, who's been leading our coverage of this story, was in the courtroom, and she's with us now live from Perugia. Good morning to you, Elizabeth. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) That's true, George. We're gonna move on now, though, to the dramatic closing arguments happening right now in the appeal of Amanda Knox. [ABSTRACT FROM PUBLISHER]

JOSH ELLIOTT (ABC NEWS) (Off-camera) Indeed. I would love to follow that. We have lots to get to actually. We begin with new details at this hour on the killing of Anwar al Awlaki, the American-born al Qaeda leader, described in some corners as the most dangerous man in the world. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) Now to the Amanda Knox trial, counting down to a decision this week. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) Now to Amanda Knox. So close to finding out if she's finally going free. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) Let's turn to Italy now and Amanda Knox, where today is the first day of the defense's closing arguments, a more promising today for her. [ABSTRACT FROM PUBLISHER]

DAVID MUIR (ABC NEWS) (Off-camera) We're gonna turn now to the case of Amanda Knox, the American student imprisoned in Italy, convicted with her boyfriend and another man in the brutal murder of her roommate. Knox is appealing her conviction, and the stakes could not be higher. "20/20" co-anchor Elizabeth Vargas is in Italy with Knox's parents tonight on that surprise in the courtroom this weekend. It's an ABC News exclusive. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) Okay. (Voiceover) Now to the Amanda Knox appeal entering it's climatic, final days, closing arguments continue today. Later this week, Amanda will face the court and make a personal plea, but will it be enough to set her free? GEORGE STEPHANOPOULOS (ABC NEWS) (CONTINUED) [ABSTRACT FROM PUBLISHER]

DAN HARRIS (ABC NEWS) (Off-camera) This is a truly fraught moment for Amanda Knox. [ABSTRACT FROM PUBLISHER]

BIANNA GOLODRYGA (ABC NEWS) (Off-camera) All right, Dan. We turn now to Amanda Knox, who may now be days from freedom. She is back in court this morning in Italy, as her appeals trial wraps up, an appeal many think she will win. But now the prosecution is laying out its final arguments. And "20/20's" co-anchor, Elizabeth Vargas, has covered the story from the beginning, and she joins us live from Perugia. Good morning, Elizabeth. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) But let's get right to those crucial closing arguments underway in Italy in the appeals trial of Amanda Knox, the Seattle student hoping to get her murder conviction overturned and return home here to the US. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Voiceover) Now to that new legal victory for Amanda Knox. As you know, she's the American student accused of killing her roommate in Italy. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) Thanks, Robin. We're gonna turn now to the Amanda Knox trial. The forensic and DNA evidence that could hold the key to her freedom will be front and center again today. [ABSTRACT FROM PUBLISHER]

JOSH ELLIOTT (ABC NEWS) (Off-camera) And in the news today, but you're right, - occupational hazard, probably the best way to get it done there. And so we begin with only one week and counting now until a possible federal default, Democrats and Republicans appear to be no closer to any deal to raise the debt limit. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) Coming up on 7:44 now. And a big day in the Amanda Knox case. Crucial DNA evidence is being re-examined at her appeals trial in Italy. [ABSTRACT FROM PUBLISHER]

BIANNA GOLODRYGA (ABC NEWS) (Off-camera) Well, crucial DNA evidence takes center stage at the Amanda Knox appeals trial tomorrow. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) We'll follow the investigation. But now, we're gonna get to the latest on that break in the Amanda Knox case. [ABSTRACT FROM PUBLISHER]

ROBIN ROBERTS (ABC NEWS) (Off-camera) A big morning for Amanda Knox, who is back in an appeals court in Italy today. [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) After 43 months behind bars, American student Amanda Knox is back in an Italian court appealing her murder conviction. She's waiting as Italian forensic experts take a new look at the DNA evidence that originally convicted her, where it was found, and almost more importantly now, where it wasn't. Could the new results finally mean freedom for the young woman still setting off international headlines? [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) We'll do a little bit of it later. We got to switch gears now... [ABSTRACT FROM PUBLISHER]

ELIZABETH VARGAS (ABC NEWS) (Off-camera) But first, this morning, we're going to look at the case around Amanda Knox. [ABSTRACT FROM PUBLISHER]

GEORGE STEPHANOPOULOS (ABC NEWS) (Off-camera) Thank you very much, Sam. And now, we're going to go behind the scenes in the Amanda Knox case. The Italian court has just revealed why they found the 22-year-old college student guilty of killing her roommate and sent her to prison for 26 years. Elizabeth Vargas has covered the case from the very beginning. You join us now with the latest, a lot of detail here. [ABSTRACT FROM PUBLISHER]

DIANE SAWYER (ABC NEWS) (Off-camera) And up next, the verdict that sent shock waves around the world, American student Amanda Knox facing 26 years in an Italian prison after being convicted in the murder of her roommate. [ABSTRACT FROM PUBLISHER]

BILL WEIR (ABC NEWS) (Off-camera) There's proof for that. All that coming up. But first, we go to Italy. And that is where Amanda Knox is beginning a 26-year prison sentence this morning after being convicted of murdering her former roommate. The verdict has left the Knox family stunned, but, they have vowed to fight on. And "20/20" anchor Elizabeth Vargas, she has been following this trial all along. And joins us now from Perugia, Italy. Elizabeth, good morning. [ABSTRACT FROM PUBLISHER]

BILL WEIR (ABC NEWS) (Off-camera) Okay, Marysol. Well, we want to go back to our lead story this morning, that conviction of American student Amanda Knox for the murder of her former roommate. She now faces 26 years in an Italian prison. And it's raising real questions about the Italian legal system. Of course, the people at the center of this storm are the family, the Knox family. And ABC's "20/20's" Elizabeth Vargas, she has been visiting with them throughout this trial. And joins us once again from Perugia. Elizabeth. [ABSTRACT FROM PUBLISHER]

BILL WEIR (ABC NEWS) But we do begin, Diane, this half-hour with breaking news in the Amanda Knox trial. The jury is deliberating this morning. They've just begun in the murder trial of that American student, meaning she could learn her fate shortly. And '20/20's" Elizabeth Vargas has been following this case from the beginning. She's back in Perugia, Italy, with more. Good morning, Elizabeth. [ABSTRACT FROM PUBLISHER]

DAVID MUIR (ABC NEWS) (Off-camera) We turn overseas this evening in Italy and a crucial day of testimony in the murder trial of an American college student, Amanda Knox. Now, five months into the trial, the prosecution questioned Amanda Knox herself about the killing of her roommate, Meredith Kercher. ABC's Elizabeth Vargas is covering the trial in Perugia, Italy. [ABSTRACT FROM PUBLISHER]

DIANE SAWYER (ABC NEWS) (Off-camera) Okay, Jeff, thanks to you. And now from Italy this morning, a new assessment of the American college student on trial for murder in an Italian courtroom. [ABSTRACT FROM PUBLISHER]

KATE SNOW (ABC NEWS) (Off-camera) Okay, Chris, thanks. People in Iran headed to the polls in droves this morning, with the political future of their country in the balance. [ABSTRACT FROM PUBLISHER]