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Background: Evaluating the dynamic knee function of patients after anterior cruciate ligament reconstruction is a challenge. A variety of objective tests have been developed but for various reasons few are regularly used in the clinic. It may be practical to perform the step-up-and-over test with an accelerometer., Methods: A control group (N=26) and an experimental group with a reconstructed anterior cruciate ligament (N=25) completed questionnaires quantifying subjective knee function and fear of re-injury and then completed the step-up-and-over test., Findings: Results showed that the experimental group performed differently than the control group for the step-up-and-over test's Lift Symmetry and Impact Symmetry (P<0.05) and performance on these measures was related to the participant's subjective knee function (ρ=-0.46, P<0.01; ρ=-0.33, P<0.05, respectively). Supplemental results for individual leg performance and the patient's fear of re-injury are also reported and discussed., Interpretation: Performance on the step-up-and-over test is different for participants with anterior cruciate ligament reconstruction than for those with intact anterior cruciate ligaments, and that performance is related to one's opinion of their knee's function., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Background: This study introduces two novel outcomes that could be used to identify people with knee osteoarthritis from healthy controls. These outcomes examine the lengths of paths on a sphere derived from knee angle and knee position during gait., Methods: Participants with moderate knee osteoarthritis (n=47) and no knee pathology (n=51) walked overground. The time-varying orientation matrices and position vectors of the knee (leg relative to the thigh) were measured, then arclength (constant speed) parameterized. The orientation matrix column aligned with the long axis of the leg, and the tangent, normal and binormal vectors (Frenet Frame) along the position vectors were calculated. These unit length vectors all scribe paths (indicatrices) on a unit sphere. The path lengths of these indicatrices, for all or part of a gait cycle, were the novel outcomes. A stepwise discriminant analysis defined a linear function that included those outcomes that best allocated a participant to the osteoarthritis or control group., Findings: Group differences were best detected with the indicatrix lengths associated with the orientation of the leg's long axis over a gait cycle (P<0.001) and the tangent vector over the stance phase (P=0.014). Both outcomes were smaller in the knee osteoarthritis compared to control group. Walking speed was poorly correlated with all indicatrix lengths (rho<|0.484|) and a discriminate analysis correctly classified 83.7% of the participants., Interpretation: Smaller indicatrix measures distinguished those with knee osteoarthritis from healthy controls. These outcomes introduce a promising new kinematic approach when examining gait data.

Introduction: Principal component analysis (PCA) has been used to reduce the volume of gait data and can also be used to identify the differences between populations. This approach has not been used on stair climbing gait data. Our objective was to use PCA to compare the gait patterns between young and older adults during stair climbing., Methods: The knee joint mechanics of 30 healthy young adults (23.9 + or - 2.6 years) and 32 healthy older adults (65.5 + or - 5.2 years) were analyzed while they ascended a custom 4-step staircase. The three-dimensional net knee joint forces, moments, and angles were calculated using typical inverse dynamics. PCA models were created for the knee joint forces, moments and angles about the three axes. The principal component scores (PC scores) generated from the model were analyzed for group differences using independent samples t-tests. A stepwise discriminant procedure determined which principal components (PCs) were most successful in differentiating the two groups., Results: The number of PCs retained for analysis was chosen using a 90% trace criterion. Of the scores generated from the PCA models nine were statistically different (p < .0019) between the two groups, four of the nine PC scores could be used to correctly classify 95% of the original group., Conclusions: The PCA and discriminant function analysis applied in this investigation identified gait pattern differences between young and older adults. Identification of stair gait pattern differences between young and older adults could help in understanding age-related changes associated with the performance of the locomotor task of stair climbing., (Copyright 2009 Elsevier B.V. All rights reserved.)

This paper investigated whether the ratio of medial-lateral hamstring muscular activation could be altered with changes in foot rotation position (both internal and external rotation) during three standard lower limb exercises. It has been suggested that those with medial compartment knee OA activate the lateral hamstrings more than the medial to help unload the diseased compartment; therefore, preferential activation of this muscle during lower limb exercise may help to further decrease the stresses on the articular cartilage and be an effective intervention for knee OA and lateral hamstring injury. Thirteen healthy young adult subjects were tested and average medial and lateral hamstring EMG data during the full exercise, as well as the concentric and eccentric phases, were used to calculate the medial-lateral (M-L) hamstring activation ratio for each exercise and foot position. Results suggest that internal foot rotation increases the M-L hamstring activation ratio while external foot rotation decreases this ratio. Therefore, altering the position of the foot during standard lower limb exercise can help selectively activate the medial or lateral hamstring muscle groups. This selective activation may have implication in treating symptoms of knee osteoarthritis and hamstring injury; but, longitudinal intervention studies would be needed to determine clinical utility.

Background: To determine the effects of changing the natural foot progression angle during gait (internal and external foot rotation) on the knee's adduction moment, lateral-medial shear force, and the ratio of medial-lateral hamstring muscle activation in those with signs of knee osteoarthritis and a matched healthy control group., Methods: Twelve subjects with signs of knee osteoarthritis and 12 matched healthy control subjects were evaluated. A 3D gait analysis system calculated forces and moments at the knee while the subjects walked in three conditions: (1) normal foot position, (2) external foot rotation, (3) internal foot rotation. Medial and lateral hamstring EMG data was also collected simultaneously and used to calculate the medial-lateral hamstring activation ratio during the stance phase of the gait cycle. Repeated measures ANOVAs were used to compare foot rotation conditions within each group; while between group comparisons were performed in the normal rotation condition only using t-tests., Findings: Those with knee osteoarthritis (OA) had an increased late stance knee adduction moment and a decreased medial-lateral hamstring activation ratio as compared to the healthy control group. Also, external foot rotation decreased the late stance knee adduction moment, lateral-medial shear force, and hamstring activation ratio. However, internal foot rotation did not increase these measures., Interpretation: Changes in foot position during gait have the ability to alter both the external loading of the knee joint and hamstring muscle activation patterns during gait. This may have implication in helping to unload the knee's articular cartilage.

Background: Pain experienced by people with knee osteoarthritis is related to psychosocial factors and damage to articular tissues and/or the pain pathway itself. Mechanical factors have been speculated to trigger this pain experience; yet mechanics have not been identified as a source of pain in this population. The purpose of this study was to identify whether mechanics could explain variance in pain intensity in people with knee osteoarthritis., Methods: Data from 53 participants with physician-diagnosed knee osteoarthritis (mean age=68.5 years; standard deviation=8.6 years) were analyzed. Pain intensity was reported on the Western Ontario and McMaster Universities Osteoarthritis Index. Mechanical measures included weight-bearing varus-valgus alignment, body mass index and isokinetic quadriceps torque. Gait analysis captured the range of adduction-abduction angle, range of flexion-extension angle and external knee adduction moment during level walking., Findings: Pain intensity was significantly related to the dynamic range of flexion-extension during gait and body mass index. A total of 29% of the variance in pain intensity was explained by mechanical variables. The range of flexion-extension explained 18% of variance in pain intensity. Body mass index added 11% to the model. The knee adduction moment was unrelated to pain intensity., Interpretation: The findings support that mechanical factors are related to knee osteoarthritis pain. Because limitations in flexion-extension range of motion and body size are modifiable factors, future research could examine whether interventions targeting these mechanics would facilitate pain management.

Purpose: This study compared the kinematics and kinetics of the knee joint during traditional step-over-step (SOS) and compensatory step-by-step lead-leg (SBSL) and trail-leg (SBST) stair ambulation patterns., Methods: Seventeen (M:9) healthy adults completed five trials of ascent and descent using three different stepping patterns: 1) SBSL, 2) SBST, and 3) SOS. Kinematics and kinetics were collected with an optoelectronic motion-tracking system and a force plate embedded into a four-step staircase. An inverse-dynamics link-segment model (QGAIT system) was used to calculate the net joint kinetics., Results: During stair ascent, different peak anteroposterior (AP) forces were observed across all three stepping patterns (SOS > SBSL > SBST, P < 0.05). During ascent, the flexion moments of SOS (0.96 N x m x kg(-1)) and SBSL (0.97 N x m x kg(-1)) patterns were similar and much larger than the SBST moments (0.14 N x m x kg(-1)). In the descent conditions, the initial AP peak force for SOS was larger than that of SBSL and SBST. However, the second peak force for SOS (4.92 N x kg(-1)) and SBST (4.68 N x kg(-1)) were larger than SBSL (1.57 N x kg(-1)). During descent, the initial peak flexion moment for the SOS pattern was larger than SBSL and SBST, whereas during the second peak, SOS (1.05 N x m x kg(-1)) and SBST (1.11 N x m x kg(-)) were no different and larger than SBSL (0.18 N x m x kg(-1))., Conclusion: Overall, SBSL during ascent and SBST during descent had the highest loads. These results increase our understanding of alternative stepping patterns and have important clinical (reduction of loading on injured/diseased leg) and rehabilitation implications.

Background: Although gait characteristics have been well documented in people with knee osteoarthritis, little is known about the relationships between gait characteristics and performance or disability. Our purpose was to examine the role of knee kinematics and kinetics on walking performance and disability in people with knee osteoarthritis. We also examined whether pain mediated the relationship between the knee adduction moment and performance or disability., Methods: Three-dimensional gait analysis was conducted on 54 people with medial compartment knee osteoarthritis. Performance was quantified with the Six Minute Walk test and disability was self-reported on the Short Form-36. The pain subscale of the Western Ontario McMaster Universities Osteoarthritis Index and the functional self-efficacy subscale of the Arthritis Self-Efficacy scale were completed., Findings: A step-wise linear regression demonstrated that the variance in Six Minute Walk test scores was explained by functional self-efficacy (50%) and the range of knee motion (8%). The variance in Short Form-36 was explained by pain (36%), the peak extension angle (19%) and the range of knee motion (4%). Pain was unrelated to the knee adduction moment so analyses of pain as a mediator of the adduction moment on either performance or disability were halted., Interpretation: Kinematic output from the motor control system is useful in understanding some variance in current performance and disability in people with knee osteoarthritis. The knee adduction moment was unrelated to these variables and pain did not mediate between the knee adduction moment and performance or disability. Therefore this moment does not explain current clinical status in people with knee osteoarthritis based on the measures of performance and disability used in this study.

Objective: Gait biomechanics (knee adduction moment, center of pressure) and static alignment were investigated to determine the mechanical effect of foot orthoses in people with medial compartment knee osteoarthritis., Design: Repeated measures design in which subjects were exposed to three conditions (normal footwear, heel wedge and orthosis) in random order., Background: The knee adduction moment is an indirect measure of medial compartment loading. It was hypothesized that the use of a 5 degrees valgus wedge and 5 degrees valgus modified orthosis would shift the center of pressure laterally during walking, thereby decreasing the adduction moment arm and the adduction moment., Methods: Peak knee adduction moment and center of pressure excursion were obtained in nine subjects with medial compartment knee OA during level walking using an optoelectric system and force plate. Static radiographs were taken in 12 subjects using precision radiographs., Results: There was no difference between conditions in static alignment, the peak adduction moment or excursion of the center of pressure in the medial-lateral direction. No relationship was found between the adduction moment and center of pressure excursion in the medial-lateral plane. The displacement of the center of pressure in the anterior-posterior direction, measured relative to the laboratory coordinate system, was decreased with the orthosis compared to the control condition (P=0.036) and this measure was correlated with the adduction moment (r=0.45, P=0.019)., Conclusions: The proposed mechanism was not supported by the findings. The reduction in the center of pressure excursion in the anterior-posterior direction suggests that foot positioning was altered, possibly to a toe-out position, while subjects wore the orthoses. Based on the current findings, we hypothesize that toe-out positioning may reduce medial joint load., Relevance: Knee Osteoarthritis is the most common cause of chronic disability amongst seniors. Developing inexpensive, non-invasive treatment strategies for this large population has potential to impact health care costs, quality of life and clinical outcomes.

Understanding joint kinetics during activities of daily living furthers our understanding of the factors involved in joint pathology and the effects of treatment. In this study, we examined hip and knee joint kinetics during stair climbing in 35 young healthy subjects using a subject-specific knee model to estimate bone-on-bone tibiofemoral and patello-femoral joint contact forces. The net knee forces were below one body weight while the peak posterior-anterior contact force was close to one body weight. The peak distal-proximal contact force was on average 3 times body weight and could be as high as 6 times body weight. These contact forces occurred at a high degree of knee flexion where there is a smaller joint contact area resulting in high contact stresses. The peak knee adduction moment was 0.42 (0.15) Nm/kg while the flexion moment was 1.16 (0.24) Nm/kg. Similar peak moment values, but different curve profiles, were found for the hip. The hip and knee posterior-anterior shear forces and the knee flexion moment were higher during stair climbing than during level walking. The most striking difference between stair ascent and level walking was that the peak patello-femoral contact force was 8 times higher during stair ascent. These data can be used as baseline measures in pathology studies, as input to theoretical joint models, and as input to mechanical joint simulators., (Copyright 2002 Elsevier Science B.V.)

This paper describes a 3-D gait analysis system, which combines optoelectric motion tracking and a standardized X-ray procedure, to calculate the net knee-joint forces and moments of a normal subject group during walking. The optoelectric system collects kinematic data from infra-red LED markers placed at selected skin surface locations and projecting probes attached to the lower limb. A standardized X-ray procedure is used to move surface markers into their designated bony landmarks based on individual bone structure, which reduces the error caused by uncertainty of skin-surface marker locations. Based on moved-in marker information, different joint coordinate systems are proposed for kinematic and kinetic analysis of the knee joint. Normalized data of knee angles, net reaction forces and net moments from 35 young, normal subjects are presented.

A semiautomatic three-dimensional knee motion assessment system has been developed based on an optoelectric motion tracking system connected to an IBM-compatible computer. Critical decisions made in implementing the software component of the system include the modelling of the thigh and lower leg segments, calculating the knee angles, reaction forces, and moments; the file structure used and the format of the programs used to process the data are outlined. Once the subject-specific data have been collected, the system of programs requires no other user-intervention during processing. Also, selected curve parameters are automatically extracted from the output and combined with the subject-specific data that include precision X-ray and anthropometric data, which are all added to a knee motion assessment database. The automated portion of the system frees the experimenter from data processing and allows concentration on data analysis.